Addressing the tumour microenvironment in early drug discovery: a strategy to overcome drug resistance and identify novel targets for cancer therapy

Framing cancer progression: influence of the organ‐ and tumour‐specific matrisome

(2020) Maria Rafaeva et al.   FEBS Journal

β1-Integrin binding to collagen type 1 transmits breast cancer cells into chemoresistance by activating ABC efflux transporters

(2020) Fabian Baltes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Organotypic cancer tissue models for drug screening: 3D constructs, bioprinting and microfluidic chips

(2020) Janani Radhakrishnan et al.   DRUG DISCOVERY TODAY

Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

(2020) Ozge Saatci et al.   Nature Communications

3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments

(2019) Fanben Meng et al.   ADVANCED MATERIALS

Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma

(2019) Eva A. Ebbing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT is associated with an epigenetic signature of ECM remodeling genes

(2019) Paul Peixoto et al.   Cell Death & Disease

Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies

(2019) Maja J. A. de Jonge et al.   Targeted Oncology

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Collagen remodeling in the hypoxic tumor-mesothelial niche promotes ovarian cancer metastasis

(2019) Suchitra Natarajan et al.   CANCER RESEARCH

On-Chip Anticancer Drug Screening – Recent Progress in Microfluidic Platforms to Address Challenges in Chemotherapy

(2019) Nandini Dhiman et al.   BIOSENSORS & BIOELECTRONICS

Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer

(2019) Scott H. Medina et al.   BIOMATERIALS

Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

(2019) Hong Jiang et al.   GUT

HIF inactivation of p53 in Ovarian Cancer Can be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity

(2019) Basmina Parmakhtiar et al.   MOLECULAR CANCER RESEARCH

Beta1 integrin blockade overcomes doxorubicin resistance in human T-cell acute lymphoblastic leukemia

(2019) Sofiane Berrazouane et al.   Cell Death & Disease

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

(2019) Matteo Ligorio et al.   CELL

Are Integrins Still Practicable Targets for Anti-Cancer Therapy?

(2019) Alday-Parejo et al.   Cancers

Biomaterial substrate-derived compact cellular spheroids mimicking the behavior of pancreatic cancer and microenvironment

(2019) Chui-Wei Wong et al.   BIOMATERIALS

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

(2019) Chenxi Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

(2019) Duc-Huy T. Nguyen et al.   Science Advances

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

(2019) Giovanni Giuseppe Giobbe et al.   Nature Communications

Cell adhesion to collagen promotes leukemia resistance to doxorubicin by reducing DNA damage through the inhibition of Rac1 activation

(2019) Dalila Naci et al.   Scientific Reports

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

(2018) Carrie J. Lovitt et al.   BMC CANCER

Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma

(2018) Rajani Kanteti et al.   CANCER BIOLOGY & THERAPY

A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance

(2018) Joerg Huelsken et al.   CELL

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy

(2018) Leonie Rossow et al.   ONCOGENE

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

A high-throughput imaging and nuclear segmentation analysis protocol for cleared 3D culture models

(2018) Molly E. Boutin et al.   Scientific Reports

Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant p53 and Can Be Overcome by Induction of Oxidative Stress

(2018) Christophe Deben et al.   Cancers

Translational in vitro research: integrating 3D drug discovery and development processes into the drug development pipeline

(2018) Jens M. Kelm et al.   DRUG DISCOVERY TODAY

High Content Screening Characterization of Head and Neck Squamous Cell Carcinoma Multicellular Tumor Spheroid Cultures Generated in 384-Well Ultra-Low Attachment Plates to Screen for Better Cancer Drug Leads

(2018) Stanton J. Kochanek et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns

(2018) Daniela Loessner et al.   BIOMATERIALS

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Breast Tumor Microenvironment Can Transform Naïve Mesenchymal Stem Cells into Tumor Forming Cells in Nude Mice

(2018) Philipp M Wörner et al.   STEM CELLS AND DEVELOPMENT

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics

(2017) Alexandra Naba et al.   JOURNAL OF PROTEOME RESEARCH

Mesenchymal stem cells: key players in cancer progression

(2017) Sarah M. Ridge et al.   Molecular Cancer

Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic Targeting

(2017) Jennifer Peyling Wang et al.   Journal of Cancer

Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy

(2017) Weiqiang Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

Assessing Drug Efficacy in a Miniaturized Pancreatic Cancer In Vitro 3D Cell Culture Model

(2016) Todd B. Shelper et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists

(2016) Mamoru Morimoto et al.   BMC CANCER

Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells

(2016) Svetlana Skolekova et al.   Cell Communication and Signaling

Extracellular Matrix Stiffening Induces a Malignant Phenotypic Transition in Breast Epithelial Cells

(2016) Ryan S. Stowers et al.   Cellular and Molecular Bioengineering

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue

(2016) Jimena G. Dancy et al.   JOURNAL OF CONTROLLED RELEASE

High-throughput imaging: Focusing in on drug discovery in 3D

(2016) Linfeng Li et al.   METHODS

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells

(2016) Anna Gutkin et al.   Oncotarget

Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma

(2015) Tommaso Azzarito et al.   CANCER LETTERS

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Tissue matrix arrays for high-throughput screening and systems analysis of cell function

(2015) Vince Z Beachley et al.   NATURE METHODS

Cell viability assessment using the Alamar blue assay: A comparison of 2D and 3D cell culture models

(2015) F. Bonnier et al.   TOXICOLOGY IN VITRO

Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells

(2015) Hui-Mei Wu et al.   Scientific Reports

CXCR4 Inhibition with AMD3100 Sensitizes Prostate Cancer to Docetaxel Chemotherapy

(2015) Urszula M. Domanska et al.   NEOPLASIA

Gelatine methacrylamide-based hydrogels: An alternative three-dimensional cancer cell culture system

(2014) Elke Kaemmerer et al.   Acta Biomaterialia

Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development

(2014) Christine Unger et al.   ADVANCED DRUG DELIVERY REVIEWS

CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells

(2014) Yu Wang et al.   BIOCHEMICAL PHARMACOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

(2014) Cristina Federici et al.   PLoS One

Tropoelastin: A versatile, bioactive assembly module

(2013) Steven G. Wise et al.   Acta Biomaterialia

Miniaturized Three-Dimensional Cancer Model for Drug Evaluation

(2013) Carrie J. Lovitt et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The Role of Tumor Tissue Architecture in Treatment Penetration and Efficacy: An Integrative Study

(2013) Katarzyna A. Rejniak et al.   Frontiers in Oncology

Microtissue size and hypoxia in HTS with 3D cultures

(2012) Amish Asthana et al.   DRUG DISCOVERY TODAY

The tumor microenvironment is a dominant force in multidrug resistance

(2012) Ana Luísa Correia et al.   DRUG RESISTANCE UPDATES

Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2

(2012) Sharon Cohen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

CXCL12–CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy

(2010) S Singh et al.   BRITISH JOURNAL OF CANCER

Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer

(2010) Lyndsay V. Rhodes et al.   CANCER RESEARCH

Disruption of Laminin-Integrin-CD151-Focal Adhesion Kinase Axis Sensitizes Breast Cancer Cells to ErbB2 Antagonists

(2010) X. H. Yang et al.   CANCER RESEARCH

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1

(2009) R. Sullivan et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

(2008) Audrey Sermeus et al.   Molecular Cancer

Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma

(2008) K Hatano et al.   ONCOGENE