Regulation of cGAS activity by RNA‐modulated phase separation

The stress granule protein G3BP1 promotes pre‐condensation of cGAS to allow rapid responses to DNA

(2021) Ming Zhao et al.   EMBO REPORTS

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

(2019) Lodoe Lama et al.   Nature Communications

Quantifying Dynamics in Phase-Separated Condensates Using Fluorescence Recovery after Photobleaching

(2019) Nicole O. Taylor et al.   BIOPHYSICAL JOURNAL

Evaluation of Viral Genome Copies Within Viral Factories on Different DNA Viruses

(2018) Zaven A. Karalyan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions

(2018) Marc Torrent et al.   Science Signaling

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

(2017) Qiang Wang et al.   PLoS Pathogens

Cytosolic DNA Sensing: The Field Narrows

(2016) Russell E. Vance   IMMUNITY

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

(2015) Anna-Maria Herzner et al.   NATURE IMMUNOLOGY

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

(2015) Gil Ju Seo et al.   Cell Reports

Non-coding RNA: what is functional and what is junk?

(2015) Alexander F. Palazzo et al.   Frontiers in Genetics

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

(2014) Arun K Mankan et al.   EMBO JOURNAL

Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors

(2014) Surya Pandey et al.   Cold Spring Harbor Perspectives in Biology

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Intracellular Water Exchange for Measuring the Dry Mass, Water Mass and Changes in Chemical Composition of Living Cells

(2013) Francisco Feijó Delgado et al.   PLoS One

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

(2013) Philip J. Kranzusch et al.   Cell Reports

Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels

(2012) Milana Frenkel-Morgenstern et al.   Molecular Systems Biology

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Exploring RNA transcription and turnover in vivo by using click chemistry

(2008) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA