Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs

Ras activation revisited: role of GEF and GAP systems

(2015) Anne Hennig et al.   BIOLOGICAL CHEMISTRY

Sos1 regulates sustained TCR-mediated Erk activation

(2014) Mateusz Poltorak et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway

(2013) C. Kumkhaek et al.   BLOOD

Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications

(2013) Sami S Azrak et al.   BMC GENOMICS

Flow cytometric chemosensitivity assay using JC-1, a sensor of mitochondrial transmembrane potential, in acute leukemia

(2013) Tomoko Yokosuka et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

4-Hydroxytamoxifen Induces Autophagic Death through K-Ras Degradation

(2013) L. Kohli et al.   CANCER RESEARCH

Functional Redundancy of Sos1 and Sos2 for Lymphopoiesis and Organismal Homeostasis and Survival

(2013) Fernando C. Baltanás et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

(2012) Nicole Warnecke et al.   EMBO REPORTS

ROS, autophagy, mitochondria and cancer: Ras, the hidden master?

(2012) Gregory L. Bellot et al.   MITOCHONDRION

Deconstructing Ras Signaling in the Thymus

(2012) R. L. Kortum et al.   MOLECULAR AND CELLULAR BIOLOGY

A gene trap knockout of the Tiam-1 protein results in malformation of the early embryonic brain

(2012) Sooyeon Yoo et al.   MOLECULES AND CELLS

Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

(2012) Hao-Hsuan Jeng et al.   Nature Communications

K-Ras and mitochondria: Dangerous liaisons

(2011) Jiri Neuzil et al.   CELL RESEARCH

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation

(2011) Antonio Castro-Castro et al.   EMBO JOURNAL

Autophagy in Ras-Induced Malignant Transformation: Fatal or Vital?

(2011) Guillermo Mariño et al.   MOLECULAR CELL

Targeted Sos1 deletion reveals its critical role in early T-cell development

(2011) R. L. Kortum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation

(2010) Stéphane Pierre et al.   BIOCHEMICAL PHARMACOLOGY

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

(2010) Matthias Drosten et al.   EMBO JOURNAL

SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery

(2010) Huan Ling Liang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation

(2010) Peng-Chieh Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms in signal transduction at the membrane

(2010) Jay T Groves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Sos2 is dispensable for NMDA-induced Erk activation and LTP induction

(2009) Junko A. Arai et al.   NEUROSCIENCE LETTERS

Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle

(2009) Esther Castellano et al.   GENOME BIOLOGY

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

(2008) Seetal Dodd et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY