Analysis of inhibitors of the anoctamin‐1 chloride channel (transmembrane member 16A, TMEM16A) reveals indirect mechanisms involving alterations in calcium signalling

A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats

(2021) Onur Cil et al.   KIDNEY INTERNATIONAL

The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin

(2021) Mami Kato et al.   Frontiers in Pharmacology

A comprehensive overview of the complex world of the endo- and sarcoplasmic reticulum Ca2+-leak channels

(2021) Fernanda O. Lemos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

(2021) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling

(2021) Ines Cabrita et al.   CELL CALCIUM

Chloride transport modulators as drug candidates

(2021) Alan S. Verkman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Signaling through the interleukin-4 and interleukin-13 receptor complexes regulate cholangiocyte TMEM16A expression and biliary secretion

(2020) Amal K Dutta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

(2020) Nicoletta Pedemonte et al.   Science Advances

Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A

(2020) Raquel Centeio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

(2019) Kent Miner et al.   Frontiers in Pharmacology

Biochemical Inhibition of DOG1/TMEM16A Achieves Antitumoral Effects in Human Gastrointestinal Stromal Tumor Cells In Vitro

(2019) ROBIN FRÖBOM et al.   ANTICANCER RESEARCH

Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A

(2019) Onur Cil et al.   FASEB JOURNAL

TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels

(2019) Michele Genovese et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A is indispensable for basal mucus secretion in airways and intestine

(2018) Roberta Benedetto et al.   FASEB JOURNAL

Differential effects of anoctamins on intracellular calcium signals

(2017) Inês Cabrita et al.   FASEB JOURNAL

Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A)

(2017) Eric C. Truong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

(2017) Hui Wang et al.   Molecular Cancer

Cellular functions of TMEM16/anoctamin

(2016) Uhtaek Oh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2

(2016) Yohan Seo et al.   PLoS One

Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte

(2014) L. Twyffels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC)

(2014) D. R. P. Sauter et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling

(2013) Adrian Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Cl- Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor

(2013) X. Jin et al.   Science Signaling

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

(2012) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride channels as drug targets

(2009) Alan S. Verkman et al.   NATURE REVIEWS DRUG DISCOVERY

Studies on expression and function of the TMEM16A calcium-activated chloride channel

(2009) Fen Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE