Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4

(2022) Wen Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway

(2022) Tong Jin et al.   FOOD AND CHEMICAL TOXICOLOGY

Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways

(2022) Hongtao Tan et al.   MOLECULAR MEDICINE

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

(2021) Yahui Ding et al.   Journal of Hematology & Oncology

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

(2021) Xiaomeng Feng et al.   Frontiers in Endocrinology

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

(2021) Guoyi Tang et al.   Acta Pharmaceutica Sinica B

Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy

(2021) Ming Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

(2021) Zhixian Wang et al.   ONCOLOGY REPORTS

The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression

(2021) Tingting Zou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

(2021) Qianjin Zhang et al.   LIFE SCIENCES

Salusin‑β participates in high glucose‑induced HK‑2 cell ferroptosis in a Nrf‑2‑dependent manner

(2021) Wen-Juan Wang et al.   Molecular Medicine Reports

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

(2021) Chengxian Xu et al.   Cell Reports

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment

(2021) Nur Samsu   Biomed Research International

A novel identified circular RNA, mmu_mmu_circRNA_0000309 involves in Germacrone-mediated the improvement of diabetic nephropathy through regulating ferroptosis by targeting miR-188-3p/GPX4 signaling axis

(2021) Juan Jin et al.   ANTIOXIDANTS & REDOX SIGNALING

Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress, inflammation and ferroptosis

(2021) Li Shao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination

(2021) Jingfa Zhang et al.   EXPERIMENTAL CELL RESEARCH

Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation

(2021) Bin Zhang et al.   PHARMACEUTICAL RESEARCH

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Macrophage Phenotype and Fibrosis in Diabetic Nephropathy

(2020) Priscila Calle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redox homeostasis maintained by GPX4 facilitates STING activation

(2020) Mutian Jia et al.   NATURE IMMUNOLOGY

Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling

(2020) Wei Huang et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

(2020) Yue Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease

(2020) Yuwei Yang et al.   TOXICOLOGY

Forkhead box protein O1 (FoxO1) /SERPINB1 ameliorates ROS production in diabetic nephropathy

(2020) Xiaoya Liang et al.   Food Science & Nutrition

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Protective effects of Croton hookeri on streptozotocin-induced diabetic nephropathy

(2019) Amit Kundu et al.   FOOD AND CHEMICAL TOXICOLOGY

The Signaling of Cellular Senescence in Diabetic Nephropathy

(2019) Yabing Xiong et al.   Oxidative Medicine and Cellular Longevity

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Classification and Differential Diagnosis of Diabetic Nephropathy

(2017) Chenyang Qi et al.   Journal of Diabetes Research

Ginkgolide B increases hydrogen sulfide and protects against endothelial dysfunction in diabetic rats

(2015) Guo-Guang Wang et al.   CROATIAN MEDICAL JOURNAL

LC–MS/MS method for the simultaneous quantification of 11 compounds of Ginkgo biloba extract in lysates of mesangial cell cultured by high glucose

(2015) Jing-ying Qiu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Combination therapy with spironolactone and candesartan protects against streptozotocin-induced diabetic nephropathy in rats

(2014) Amal Hofni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Temporal Trends in the Prevalence of Diabetic Kidney Disease in the United States

(2011) Ian H. de Boer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION