Tumor-derived extracellular vesicles in melanoma immune response and immunotherapy

Exosome-mediated delivery of transforming growth factor-β receptor 1 kinase inhibitors and toll-like receptor 7/8 agonists for combination therapy of tumors

(2022) Joo Hang Lee et al.   Acta Biomaterialia

Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma

(2022) Simona Serratì et al.   Molecular Cancer

A phase I study of the safety and efficacy of talimogene laherparepvec in Japanese patients with advanced melanoma

(2022) Naoya Yamazaki et al.   CANCER SCIENCE

Tumour‐associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles

(2022) Pankaj Kumar et al.   IMMUNOLOGY

Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

(2022) Zijie Xu et al.   MOLECULAR THERAPY

Challenges and directions in studying cell–cell communication by extracellular vesicles

(2022) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TIM-3 shuttled by MV3 cells-secreted exosomes inhibits CD4+ T cell immune function and induces macrophage M2 polarization to promote the growth and metastasis of melanoma cells

(2022) Xinghui Li et al.   Translational Oncology

Agents of cancer immunosurveillance: HSPs and dsDNA

(2022) Devanshi A. Nayak et al.   TRENDS IN IMMUNOLOGY

Rescuing Cancer Immunity by Plasma Exchange in Metastatic Melanoma (ReCIPE-M1): protocol for a single-institution, open-label safety trial of plasma exchange to clear sPD-L1 for immunotherapy

(2022) Tara M Davidson et al.   BMJ Open

A Hoechst Reporter Enables Visualization of Drug Engagement In Vitro and In Vivo: Toward Safe and Effective Nanodrug Delivery

(2022) Takuya Miyazaki et al.   ACS Nano

Cancer vaccines: Building a bridge over troubled waters

(2022) MacLean C. Sellars et al.   CELL

Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective Colon cancer therapy

(2022) Yosif Almoshari et al.   DRUG DELIVERY

Regulatory T‐cell development in the tumor microenvironment

(2022) Kota Itahashi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors

(2022) Lei Guan et al.   Nature Communications

Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments

(2022) Weili Wang et al.   Nature Communications

Emerging concepts regarding pro- and anti tumor properties of B cells in tumor immunity

(2022) You Qin et al.   Frontiers in Immunology

Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study

(2022) Irene M. Shui et al.   Journal for ImmunoTherapy of Cancer

Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms

(2022) Neftali Ortega Alarcon et al.   Pharmaceutics

Melanoma-derived small extracellular vesicles remodel the systemic onco-immunity via disrupting hematopoietic stem cell proliferation and differentiation

(2022) Zhimin Du et al.   CANCER LETTERS

CAR NK cell therapy in hematologic malignancies and solid tumors; obstacles and strategies to overcome the challenges

(2022) Ayda Baghery Saghchy Khorasani et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

(2021) Eryn Blass et al.   Nature Reviews Clinical Oncology

Extracellular vesicles in cancer diagnostics and therapeutics

(2021) Adeeb Shehzad et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization

(2021) Nian Liu et al.   MOLECULAR THERAPY

Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy

(2021) Anne Montfort et al.   Cancer Immunology Research

Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis

(2021) Shichuan Hu et al.   Acta Biomaterialia

PDL1‐positive exosomes suppress antitumor immunity by inducing tumor‐specific CD8 + T cell exhaustion during metastasis

(2021) Ji Chen et al.   CANCER SCIENCE

Imaging dendritic cell functions*

(2021) Berislav Bošnjak et al.   IMMUNOLOGICAL REVIEWS

Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy

(2021) Shengbo Zhang et al.   TRENDS IN IMMUNOLOGY

Extracellular vesicles and immunogenic stress in cancer

(2021) Qi Wu et al.   Cell Death & Disease

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

(2021) Guohao Wang et al.   Nature Communications

Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma

(2021) Elena Y. Komarova et al.   Scientific Reports

Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a

(2021) Yuta Nakazawa et al.   eLife

Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments

(2021) Maulasri Bhatta et al.   Journal for ImmunoTherapy of Cancer

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

(2020) Jorge Larios et al.   JOURNAL OF CELL BIOLOGY

Melanoma cell-derived exosomes in plasma of melanoma patients suppress functions of immune effector cells

(2020) Priyanka Sharma et al.   Scientific Reports

Melanoma-Derived Exosomal miR-125b-5p Educates Tumor Associated Macrophages (TAMs) by Targeting Lysosomal Acid Lipase A (LIPA)

(2020) Dennis Gerloff et al.   Cancers

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

Acquired Resistance to Immune Checkpoint Inhibitors

(2020) Adam J. Schoenfeld et al.   CANCER CELL

Advanced drug delivery 2020 and beyond: Perspectives on the future

(2020) You Han Bae et al.   ADVANCED DRUG DELIVERY REVIEWS

Exosome-Containing Preparations From Postirradiated Mouse Melanoma Cells Delay Melanoma Growth In Vivo by a Natural Killer Cell–Dependent Mechanism

(2020) Kishore Kumar Jella et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Exploring the NK cell platform for cancer immunotherapy

(2020) Jacob A. Myers et al.   Nature Reviews Clinical Oncology

PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

(2020) Xiaozhe Yin et al.   Cell Reports

Non-coding RNA derived from extracellular vesicles in cancer immune escape: Biological functions and potential clinical applications

(2020) Mingyao Huang et al.   CANCER LETTERS

Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature

(2019) Xinguo Jiang et al.   CIRCULATION

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Melanoma extracellular vesicles generate immunosuppressive myeloid cells by PD-L1 upregulation via TLR4 signaling

(2019) Viktor Fleming et al.   CANCER RESEARCH

MiR-135-5p-p62 Axis Regulates Autophagic Flux, Tumorigenic Potential, and Cellular Interactions Mediated by Extracellular Vesicles During Allergic Inflammation

(2019) Misun Kim et al.   Frontiers in Immunology

Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

(2019) Horrevorts et al.   Cancers

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment

(2019) Yangjing Zhao et al.   Cellular & Molecular Immunology

Regulation of the Cell Biology of Antigen Cross-Presentation

(2018) J. Magarian Blander   Annual Review of Immunology

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

(2018) Peiming Zheng et al.   Cell Death & Disease

Melanoma-released exosomes directly activate the mitochondrial apoptotic pathway of CD4+ T cells through their microRNA cargo

(2018) Ji Zhou et al.   EXPERIMENTAL CELL RESEARCH

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

(2018) Veronica Huber et al.   JOURNAL OF CLINICAL INVESTIGATION

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide

(2017) Masaki Morishita et al.   MOLECULAR PHARMACEUTICS

Melanoma exosomes deliver a complex biological payload that upregulates PTPN11 to suppress T lymphocyte function

(2017) Yueting Wu et al.   Pigment Cell & Melanoma Research

Human Melanoma-Derived Extracellular Vesicles Regulate Dendritic Cell Maturation

(2017) Rachel L. G. Maus et al.   Frontiers in Immunology

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

(2017) Marek Wieczorek et al.   Frontiers in Immunology

Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes

(2016) Joshua L. Hood   MEDICAL HYPOTHESES

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces

(2016) Chigusa Nakahashi-Oda et al.   NATURE IMMUNOLOGY

Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities

(2016) L Y Lin et al.   ONCOGENE

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

(2016) F. Pucci et al.   SCIENCE

Myeloid-derived suppressor cells and tumor escape from immune surveillance

(2016) Viktor Umansky et al.   Seminars in Immunopathology

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses

(2012) Chenjie Yang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Melanoma cell-derived exosomes alter macrophage and dendritic cell functions in vitro

(2012) Annamaria Marton et al.   IMMUNOLOGY LETTERS

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC