Melanoma-derived small extracellular vesicles remodel the systemic onco-immunity via disrupting hematopoietic stem cell proliferation and differentiation

Single-cell analysis at the protein level delineates intracellular signaling dynamic during hematopoiesis

(2021) Jinheng Wang et al.   BMC BIOLOGY

The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors

(2021) Xuyang Yang et al.   Frontiers in Molecular Biosciences

Phenotypic analysis of extracellular vesicles: a review on the applications of fluorescence

(2020) Maria S. Panagopoulou et al.   Journal of Extracellular Vesicles

The role of T cell trafficking in CTLA-4 blockade-induced gut immunopathology

(2020) Shashuang Zhang et al.   BMC BIOLOGY

Systemic dysfunction and plasticity of the immune macroenvironment in cancer models

(2020) Breanna M. Allen et al.   NATURE MEDICINE

The influence of microenvironment on tumor immunotherapy

(2019) Jieying Zhang et al.   FEBS Journal

Clonal replacement of tumor-specific T cells following PD-1 blockade

(2019) Kathryn E. Yost et al.   NATURE MEDICINE

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression

(2018) Heng Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biogenesis and function of extracellular vesicles in cancer

(2018) Maarten P. Bebelman et al.   PHARMACOLOGY & THERAPEUTICS

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

(2018) Melissa A. Meyer et al.   Nature Communications

De-novo and acquired resistance to immune checkpoint targeting

(2017) Nicholas L Syn et al.   LANCET ONCOLOGY

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression

(2016) Jinheng Wang et al.   JOURNAL OF PATHOLOGY

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

(2016) D. Mathios et al.   Science Translational Medicine

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche

(2015) Amber Jin Giles et al.   CANCER RESEARCH

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

(2015) Amy-Jo Casbon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells

(2015) Jinheng Wang et al.   Oncotarget

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells

(2014) J. Wang et al.   BLOOD

Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development

(2014) Sean C. Bendall et al.   CELL

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

Regulation of exosome release from mammary epithelial and breast cancer cells – A new regulatory pathway

(2014) Andrew Riches et al.   EUROPEAN JOURNAL OF CANCER

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis

(2014) Arnoud J. Templeton et al.   JNCI-Journal of the National Cancer Institute

Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients

(2014) W.-C. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-Derived Suppressor Cells as Therapeutic Target in Hematological Malignancies

(2014) Kim De Veirman et al.   Frontiers in Oncology

Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells

(2013) A. Sio et al.   CANCER RESEARCH

Molecular mechanisms of platelet and stem cell rebound after 5-fluorouracil treatment

(2013) Xiaomiao Li et al.   EXPERIMENTAL HEMATOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

(2011) Peng Qiu et al.   NATURE BIOTECHNOLOGY

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY