Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide

α-Actinin-4 confers radioresistance coupled invasiveness in breast cancer cells through AKT pathway

(2018) Sejal Desai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The role of STAT3 in leading the crosstalk between human cancers and the immune system

(2018) Yu Wang et al.   CANCER LETTERS

Niclosamide: Beyond an antihelminthic drug

(2018) Wei Chen et al.   CELLULAR SIGNALLING

Simvastatin inhibits the development of radioresistant esophageal cancer cells by increasing the radiosensitivity and reversing EMT process via the PTEN-PI3K/AKT pathway

(2018) Yingying Jin et al.   EXPERIMENTAL CELL RESEARCH

Alkynyl gold(I) complex triggers necroptosis via ROS generation in colorectal carcinoma cells

(2017) Inés Mármol et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells

(2017) B Peter et al.   LEUKEMIA

Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152

(2017) Yu Wang et al.   MOLECULAR CANCER THERAPEUTICS

Breast Cancer

(2017) Robert W. Carlson et al.   Journal of the National Comprehensive Cancer Network

Gene Expression Profiling in Breast Cancer

(2017) Kiran Turaga et al.   Cancer Control

3,3′-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice

(2016) Lu Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of STAT3 enhances the radiosensitizing effect of temozolomide in glioblastoma cells in vitro and in vivo

(2016) Tae Jin Han et al.   JOURNAL OF NEURO-ONCOLOGY

Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer

(2016) Rebecca C. Arend et al.   Oncotarget

Abstract P6-12-04: Targeting STAT3 with novel small molecule inhibitors to sensitize breast cancer cells to radiation therapy

(2015) Lili Wang et al.   CANCER RESEARCH

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair

(2015) Hai Liu et al.   OncoTargets and Therapy

Effect of Niclosamide on Basal-like Breast Cancers

(2014) A. I. Londono-Joshi et al.   MOLECULAR CANCER THERAPEUTICS

AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells

(2014) Tsutomu Shimura et al.   RADIOTHERAPY AND ONCOLOGY

Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer

(2013) S. You et al.   MOLECULAR CANCER THERAPEUTICS

DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism

(2013) S. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating Breast Cancer in the 21st Century: Emerging Biological Therapies

(2013) Gabriel Tinoco et al.   Journal of Cancer

Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells

(2012) Xiaoying Liu et al.   BIOCHEMICAL PHARMACOLOGY

Disrupting the mTOR Signaling Network as a Potential Strategy for the Enhancement of Cancer Radiotherapy

(2012) Francis J. Dumont et al.   CURRENT CANCER DRUG TARGETS

mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring anEGFRactivating mutation by inducing autophagy

(2012) Eun Ju Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

(2012) Jing-Xuan Pan et al.   Chinese Journal of Cancer

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia

(2011) W. Warsch et al.   BLOOD

Nodal Status and Clinical Outcomes in a Large Cohort of Patients With Triple-Negative Breast Cancer

(2011) Leonel F. Hernandez-Aya et al.   JOURNAL OF CLINICAL ONCOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF- B Pathway and Generation of Reactive Oxygen Species

(2010) Y. Jin et al.   CANCER RESEARCH

Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3β-mediated cyclin D1 overexpression

(2010) T Shimura et al.   ONCOGENE

Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

(2010) Xiaomei Ren et al.   ACS Medicinal Chemistry Letters

Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer

(2009) Carey K. Anders et al.   Clinical Breast Cancer

Reciprocal Effects of STAT5 and STAT3 in Breast Cancer

(2009) S. R. Walker et al.   MOLECULAR CANCER RESEARCH

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE