The neuronal insulin receptor in its environment

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease

(2016) Laura T. Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice

(2016) Molly Stanley et al.   JOURNAL OF NEUROSCIENCE

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Structural Dynamics of Insulin Receptor and Transmembrane Signaling

(2015) Suren A. Tatulian   BIOCHEMISTRY

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

(2015) Claudia A. Grillo et al.   DIABETES

Fasting-Induced Lipolysis and Hypothalamic Insulin Signaling Are Regulated by Neuronal Glucosylceramide Synthase

(2015) Silke Herzer et al.   DIABETES

Growth hormone, insulin-like growth factor-1 and the aging brain

(2015) Nicole M. Ashpole et al.   EXPERIMENTAL GERONTOLOGY

Severe learning deficits of IRSp53 mutant mice are caused by altered NMDA receptor-dependent signal transduction

(2015) Kristin Bobsin et al.   JOURNAL OF NEUROCHEMISTRY

Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses

(2015) Hanaa S. Sallam et al.   JOURNAL OF NEUROCHEMISTRY

Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators

(2015) Daniel H. Bedinger et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

(2015) Woosuk Chung et al.   NATURE NEUROSCIENCE

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

(2015) Claire J. Garwood et al.   Molecular Brain

Ligand-Binding Affinity at the Insulin Receptor Isoform-A and Subsequent IR-A Tyrosine Phosphorylation Kinetics are Important Determinants of Mitogenic Biological Outcomes

(2015) Harinda Rajapaksha et al.   Frontiers in Endocrinology

First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

(2014) Christian Hölscher   Alzheimers & Dementia

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes

(2014) Farah Alghamdi et al.   CELLULAR SIGNALLING

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Insulin Regulates Brain Function, but How Does It Get There?

(2014) S. M. Gray et al.   DIABETES

GABAergic Neurogliaform Cells Represent Local Sources of Insulin in the Cerebral Cortex

(2014) G. Molnar et al.   JOURNAL OF NEUROSCIENCE

MHC Class I Limits Hippocampal Synapse Density by Inhibiting Neuronal Insulin Receptor Signaling

(2014) T. J. Dixon-Salazar et al.   JOURNAL OF NEUROSCIENCE

Lipid dynamics at dendritic spines

(2014) Carlos Gerardo Dotti et al.   Frontiers in Neuroanatomy

The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

(2013) Colin W. Ward et al.   BIOESSAYS

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance

(2013) Li-Yu Huang et al.   CELL RESEARCH

Proteomic analysis of postsynaptic density in Alzheimer's Disease

(2013) Jianying Zhou et al.   CLINICA CHIMICA ACTA

Positive Regulation of Insulin Signaling by Neuraminidase 1

(2013) L. Dridi et al.   DIABETES

Super-Resolution Imaging Reveals That AMPA Receptors Inside Synapses Are Dynamically Organized in Nanodomains Regulated by PSD95

(2013) D. Nair et al.   JOURNAL OF NEUROSCIENCE

The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase

(2013) S. R. Hubbard   Cold Spring Harbor Perspectives in Biology

Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A

(2012) Alaide Morcavallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance

(2012) Amit Gupta et al.   MOLECULAR BIOLOGY OF THE CELL

Insulin in the Brain: Sources, Localization and Functions

(2012) Rasoul Ghasemi et al.   MOLECULAR NEUROBIOLOGY

The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

(2012) Caitriona M. Long-Smith et al.   NEUROMOLECULAR MEDICINE

Insulin Receptor β-Subunit Haploinsufficiency Impairs Hippocampal Late-Phase LTP and Recognition Memory

(2012) Robert Nisticò et al.   NEUROMOLECULAR MEDICINE

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease

(2011) Oliver Stöhr et al.   AGE

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms

(2011) Louise Knudsen et al.   BIOCHEMICAL JOURNAL

Role for Insulin Signaling in Catecholaminergic Neurons in Control of Energy Homeostasis

(2011) A. Christine Könner et al.   Cell Metabolism

Presenilin Regulates Insulin Signaling via a γ-Secretase-independent Mechanism

(2011) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Insulin Reduces Neuronal Excitability by Turning on GABAA Channels that Generate Tonic Current

(2011) Zhe Jin et al.   PLoS One

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

(2010) Helena Decker et al.   JOURNAL OF NEUROCHEMISTRY

Insulin receptor signaling in the development of neuronal structure and function

(2010) Shu-Ling Chiu et al.   Neural Development

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Effects of exercise training on hippocampus concentrations of insulin and IGF-1 in diabetic rats

(2009) Ricardo José Gomes et al.   HIPPOCAMPUS

The Insulin Receptor Substrate of 53 kDa (IRSp53) Limits Hippocampal Synaptic Plasticity

(2009) Corinna Sawallisch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced NMDA Receptor-Mediated Synaptic Transmission, Enhanced Long-Term Potentiation, and Impaired Learning and Memory in Mice Lacking IRSp53

(2009) M.-H. Kim et al.   JOURNAL OF NEUROSCIENCE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Mechanisms involved in cholesterol-induced neuronal insulin resistance

(2009) Changiz Taghibiglou et al.   NEUROPHARMACOLOGY

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53

(2008) M HEUNG et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL