PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance

Focal adhesion kinase negatively regulates neuronal insulin resistance

(2012) Amit Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic  -Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

(2012) E. P. Cai et al.   DIABETES

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice: Potential Role of Tyrosine Nitration of Insulin Signaling Proteins

(2010) A. Charbonneau et al.   DIABETES

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Angiotensin II Inhibits Insulin-Stimulated GLUT4 Translocation and Akt Activation through Tyrosine Nitration-Dependent Mechanisms

(2010) Alfredo Csibi et al.   PLoS One

Dysregulation of Insulin Signaling, Glucose Transporters, O -GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

(2009) Yanqiu Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting focal adhesion kinase signaling in tumor growth and metastasis

(2009) Joerg Schwock et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase☆

(2009) Amit Gupta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Antibody binding to cell surface amyloid precursor protein induces neuronal injury by deregulating the phosphorylation of focal adhesion signaling related proteins

(2009) Yu-Xia Xu et al.   NEUROSCIENCE LETTERS

Aging-Associated Dysfunction of Akt/Protein Kinase B: S-Nitrosylation and Acetaminophen Intervention

(2009) Miaozong Wu et al.   PLoS One

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling

(2008) Hideko Hayashi et al.   GENES TO CELLS

In vivoinhibition of focal adhesion kinase causes insulin resistance

(2008) Bharti Bisht et al.   JOURNAL OF PHYSIOLOGY-LONDON

PTEN Down-Regulation by Unsaturated Fatty Acids Triggers Hepatic Steatosis via an NF-κBp65/mTOR-Dependent Mechanism

(2007) Manlio Vinciguerra et al.   GASTROENTEROLOGY

Integrins mediate β-amyloid-induced cell-cycle activation and neuronal death

(2007) Giuseppina Frasca et al.   JOURNAL OF NEUROSCIENCE RESEARCH