Dynamic Magneto-Softening of 3D Hydrogel Reverses Malignant Transformation of Cancer Cells and Enhances Drug Efficacy

Softening redox homeostasis in cancer cells

(2022) Justin A. Powers et al.   NATURE CELL BIOLOGY

Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance

(2022) Patrizia Romani et al.   NATURE CELL BIOLOGY

Matrix Stiffness Contributes to Cancer Progression by Regulating Transcription Factors

(2022) Seiichiro Ishihara et al.   Cancers

Tuning Strain Stiffening of Protein Hydrogels by Charge Modification

(2022) Jie Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

(2022) Yangfu Jiang et al.   Journal of Hematology & Oncology

Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy

(2022) Di Zhang et al.   Nature Nanotechnology

Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system

(2022) Yufeng Shou et al.   Materials Today Bio

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

(2021) Asieh Emami Nejad et al.   Cancer Cell International

Targeting Nrf2 may reverse the drug resistance in ovarian cancer

(2021) Danjie Li et al.   Cancer Cell International

Mechanical Regulation of Transcription: Recent Advances

(2021) Kaustubh Wagh et al.   TRENDS IN CELL BIOLOGY

Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

(2021) Heming Ge et al.   Frontiers in Oncology

Engineering a Vascularized 3D Hybrid System to Model Tumor-Stroma Interactions in Breast Cancer

(2021) Filipa C. Teixeira et al.   Frontiers in Bioengineering and Biotechnology

Synthesis and characterization of site selective photo-crosslinkable glycidyl methacrylate functionalized gelatin-based 3D hydrogel scaffold for liver tissue engineering

(2021) Md Moniruzzaman Sk et al.   Materials Science & Engineering C-Materials for Biological Applications

Magnetic Stiffening in 3D Cell Culture Matrices

(2021) Wen Chen et al.   NANO LETTERS

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

(2021) Alba Nicolas-Boluda et al.   eLife

3D In Vitro Models for Investigating the Role of Stiffness in Cancer Invasion

(2021) Auxtine Micalet et al.   ACS Biomaterials-Science & Engineering

An Updated Understanding of the Role of YAP in Driving Oncogenic Responses

(2021) Giampaolo Morciano et al.   Cancers

Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression

(2021) Xiaomin Cai et al.   Frontiers in Cell and Developmental Biology

Magnetic nanocomposite hydrogel with tunable stiffness for probing cellular responses to matrix stiffening

(2021) Tianhao Yan et al.   Acta Biomaterialia

A proximity proteomics screen in three-dimensional spheroid cultures identifies novel regulators of lumen formation

(2021) Li-Ting Wang et al.   Scientific Reports

Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy

(2021) Vaibhav Mahajan et al.   Cancers

Potential Applications of NRF2 Modulators in Cancer Therapy

(2020) Emiliano Panieri et al.   Antioxidants

Collagen microarchitecture mechanically controls myofibroblast differentiation

(2020) Bo Ri Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

(2020) Sylvie Brassart-Pasco et al.   Frontiers in Oncology

Epithelial–Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance

(2020) Alex J. Gooding et al.   MOLECULAR CANCER RESEARCH

Preparation and Characterization of Attractive Poly(amino acid) Hydrogels Based on 2-Ureido-4[1H]-Pyrimidinone

(2020) Zhen Shi et al.   CHINESE JOURNAL OF POLYMER SCIENCE

Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling

(2019) Matthew G. Ondeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain-Stiffening of Agarose Gels

(2019) Kia Bertula et al.   ACS Macro Letters

Nrf2 in cancers: A double‐edged sword

(2019) Shijia Wu et al.   Cancer Medicine

Precise Construction of Cell-Instructive 3D Microenvironments by Photopatterning a Biodegradable Hydrogel

(2019) Zhengwei Cai et al.   CHEMISTRY OF MATERIALS

Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

(2019) Yinying Dong et al.   Journal of Hematology & Oncology

A 3D Magnetic Hyaluronic Acid Hydrogel for Magnetomechanical Neuromodulation of Primary Dorsal Root Ganglion Neurons

(2018) Andy Tay et al.   ADVANCED MATERIALS

Collective Cell Behavior in Mechanosensing of Substrate Thickness

(2018) Camelia G. Tusan et al.   BIOPHYSICAL JOURNAL

Mesenchylmal Stem Cell Culture on Poly(N-isopropylacrylamide) Hydrogel with Repeated Thermo-Stimulation

(2018) Aya Akimoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Correction to: Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry

(2018) Natalia Davidenko et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

(2018) Arthur Winer et al.   MOLECULAR CANCER THERAPEUTICS

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Oxygen insensitive thiol–ene photo-click chemistry for direct imprint lithography of oxides

(2018) Ravikiran Nagarjuna et al.   RSC Advances

Dynamic electro-regulation of the stiffness gradient hydrogels

(2018) Runhuai Yang et al.   RSC Advances

Cellular Mechanotransduction: From Tension to Function

(2018) Fabiana Martino et al.   Frontiers in Physiology

A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment

(2018) Somoshree Sengupta et al.   Journal of Advanced Research

Extracellular pH Regulates Bone Cell Function

(2018) Timothy R. Arnett   JOURNAL OF NUTRITION

Identification of a functional antioxidant response element at the HIF1A locus

(2018) Sarah E. Lacher et al.   Redox Biology

Phenotypic Basis for Matrix Stiffness-Dependent Chemoresistance of Breast Cancer Cells to Doxorubicin

(2018) M. Hunter Joyce et al.   Frontiers in Oncology

Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle

(2018) Weixiu Ji et al.   PLoS One

The tension biology of wound healing

(2017) Hans I-Chen Harn et al.   EXPERIMENTAL DERMATOLOGY

A biomaterial screening approach reveals microenvironmental mechanisms of drug resistance

(2017) Alyssa D. Schwartz et al.   Integrative Biology

Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes

(2017) Youyun Liang et al.   MACROMOLECULAR BIOSCIENCE

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

(2017) Armen H. Mekhdjian et al.   MOLECULAR BIOLOGY OF THE CELL

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

(2017) Joan Chang et al.   Oncotarget

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Exploring the Role of RGD-Recognizing Integrins in Cancer

(2017) Markus Nieberler et al.   Cancers

Magnetic nanoparticle containing thiol-ene crosslinked hydrogels for controlled and targeted release of hydrophobic drugs

(2016) Burcu Oktay et al.   POLYMER COMPOSITES

Matrix stiffening promotes a tumor vasculature phenotype

(2016) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Age of Cortical Neural Networks Affects Their Interactions with Magnetic Nanoparticles

(2016) Andy Tay et al.   Small

Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition

(2016) Spencer C. Wei et al.   TRENDS IN CELL BIOLOGY

Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia

(2016) Jhih-Pu Syu et al.   Oncotarget

Dynamic Reciprocity Between Cells and Their Microenvironment in Reproduction1

(2015) Jeffrey T. Thorne et al.   BIOLOGY OF REPRODUCTION

ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

(2015) Peijing Zhang et al.   CELL CYCLE

Engineering cancer microenvironments for in vitro 3-D tumor models

(2015) Waseem Asghar et al.   Materials Today

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro

(2014) Kenjirou Ogawa et al.   BMC Complementary and Alternative Medicine

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence That Breast Tissue Stiffness Is Associated with Risk of Breast Cancer

(2014) Norman F. Boyd et al.   PLoS One

Fully biodegradable antibacterial hydrogels via thiol–ene “click” chemistry

(2014) Hong Du et al.   Polymer Chemistry

Thermorheology of living cells—impact of temperature variations on cell mechanics

(2013) Tobias R Kießling et al.   NEW JOURNAL OF PHYSICS

Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species

(2013) Rajitha T Kolamunne et al.   Redox Biology

Tumour Hypoxia Affects the Responsiveness of Cancer Cells to Chemotherapy and Promotes Cancer Progression

(2012) Jean-Philippe Cosse et al.   Anti-Cancer Agents in Medicinal Chemistry

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Advantages of RGD peptides for directing cell association with biomaterials

(2011) Susan L. Bellis   BIOMATERIALS

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Cobalt Ferrite Nanoparticles as Multifunctional Cross-Linkers in PAAm Ferrohydrogels

(2011) Renate Messing et al.   MACROMOLECULES

Epithelial-mesenchymal transition in breast cancer progression and metastasis

(2011) Yifan Wang et al.   Chinese Journal of Cancer

Toxicity of gold-nanoparticles: Synergistic effects of shape and surface functionalization on micromotility of epithelial cells

(2010) Marco Tarantola et al.   Nanotoxicology

Enhanced hardening of soft self-assembled copolymer gels under homogeneous magnetic fields

(2010) Haining An et al.   Soft Matter

Cell death and lumen formation in spheroids of MCF-7 cells

(2009) Jônatas Bussador do Amaral et al.   CELL BIOLOGY INTERNATIONAL

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Size-, Composition- and Shape-Dependent Toxicological Impact of Metal Oxide Nanoparticles and Carbon Nanotubes toward Bacteria

(2009) Angélique Simon-Deckers et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

Cytotoxicity of Nanoparticles

(2007) Nastassja Lewinski et al.   Small