Innate Immune Stimulation Using 3D Wireframe DNA Origami

Controlling Nuclease Degradation of Wireframe DNA Origami with Minor Groove Binders

(2022) Eike-Christian Wamhoff et al.   ACS Nano

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

(2022) Alice Comberlato et al.   NANO LETTERS

DNA Origami Nanostructures Elicit Dose‐Dependent Immunogenicity and Are Nontoxic up to High Doses In Vivo

(2022) Christopher R. Lucas et al.   Small

TLR Agonists as Vaccine Adjuvants Targeting Cancer and Infectious Diseases

(2021) Marina Luchner et al.   Pharmaceutics

In Situ Covalent Functionalization of DNA Origami Virus-like Particles

(2021) Grant A. Knappe et al.   ACS Nano

Rapid prototyping of arbitrary 2D and 3D wireframe DNA origami

(2021) Hyungmin Jun et al.   NUCLEIC ACIDS RESEARCH

Endosomal Organization of CpG Constructs Correlates with Enhanced Immune Activation

(2020) Kwahun Lee et al.   NANO LETTERS

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

(2020) Rémi Veneziano et al.   Nature Nanotechnology

A DNA nanodevice-based vaccine for cancer immunotherapy

(2020) Shaoli Liu et al.   NATURE MATERIALS

Use of human peripheral blood mononuclear cells to define immunological properties of nucleic acid nanoparticles

(2020) Marina A. Dobrovolskaia et al.   Nature Protocols

Automated Sequence Design of 3D Polyhedral Wireframe DNA Origami with Honeycomb Edges

(2019) Hyungmin Jun et al.   ACS Nano

Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

(2019) Enping Hong et al.   MOLECULES

Below the surface: The inner lives of TLR4 and TLR9

(2019) Laura Marongiu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds

(2019) Floris A. S. Engelhardt et al.   ACS Nano

Immunostimulatory activity of Y-shaped DNA nanostructures mediated through the activation of TLR9

(2019) Gabsik Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Bioproduction of pure, kilobase-scale single-stranded DNA

(2019) Tyson R. Shepherd et al.   Scientific Reports

Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity

(2019) Yi-Nan Zhang et al.   NANO LETTERS

Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes

(2019) Syuan-Ming Guo et al.   Nature Communications

Smaller CpG-Conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation

(2018) Jun Yue et al.   ACS Applied Materials & Interfaces

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

(2018) Umeharu Ohto et al.   IMMUNITY

Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

(2018) Enping Hong et al.   NANO LETTERS

Extra-Large Pore Mesoporous Silica Nanoparticles Enabling Co-Delivery of High Amounts of Protein Antigen and Toll-like Receptor 9 Agonist for Enhanced Cancer Vaccine Efficacy

(2018) Bong Geun Cha et al.   ACS Central Science

Biotechnological mass production of DNA origami

(2017) Florian Praetorius et al.   NATURE

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

(2017) Nandhini Ponnuswamy et al.   Nature Communications

Multiplexed 3D super-resolution imaging of whole cells using spinning disk confocal microscopy and DNA-PAINT

(2017) Florian Schueder et al.   Nature Communications

Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses

(2017) Jardin A. Leleux et al.   Cell Reports

Size, Shape, and Sequence-Dependent Immunogenicity of RNA Nanoparticles

(2017) Sijin Guo et al.   Molecular Therapy-Nucleic Acids

Computer-Aided Production of Scaffolded DNA Nanostructures from Flat Sheet Meshes

(2016) Erik Benson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

Designer nanoscale DNA assemblies programmed from the top down

(2016) R. Veneziano et al.   SCIENCE

Synthetic Nanoparticles for Vaccines and Immunotherapy

(2015) Darrell J. Irvine et al.   CHEMICAL REVIEWS

Minimal Sequence Requirements for Oligodeoxyribonucleotides Activating Human TLR9

(2015) Jelka Pohar et al.   JOURNAL OF IMMUNOLOGY

Activation and Regulation of DNA-Driven Immune Responses

(2015) Søren R. Paludan   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

DNA rendering of polyhedral meshes at the nanoscale

(2015) Erik Benson et al.   NATURE

Designing DNA nanodevices for compatibility with the immune system of higher organisms

(2015) Sunaina Surana et al.   Nature Nanotechnology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

(2014) Kevin S. Bonham et al.   CELL

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

TLR8: the forgotten relative revindicated

(2012) Jorge L Cervantes et al.   Cellular & Molecular Immunology

A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines

(2012) Xiaowei Liu et al.   NANO LETTERS

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Designer nucleic acids to probe and program the cell

(2012) Yamuna Krishnan et al.   TRENDS IN CELL BIOLOGY

Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures

(2011) Verena J. Schüller et al.   ACS Nano

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

(2011) Jiang Li et al.   ACS Nano

Size-Dependent Attenuation of TLR9 Signaling by Gold Nanoparticles in Macrophages

(2011) C.-Y. Tsai et al.   JOURNAL OF IMMUNOLOGY

A primer to scaffolded DNA origami

(2011) Carlos Ernesto Castro et al.   NATURE METHODS

Effects of particle size on toll-like receptor 9-mediated cytokine profiles

(2010) Helen C. Chen et al.   BIOMATERIALS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

Rapid prototyping of 3D DNA-origami shapes with caDNAno

(2009) Shawn M. Douglas et al.   NUCLEIC ACIDS RESEARCH

Folding DNA into Twisted and Curved Nanoscale Shapes

(2009) H. Dietz et al.   SCIENCE

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer

(2008) A M Krieg   ONCOGENE

The TLR3 signaling complex forms by cooperative receptor dimerization

(2008) J. N. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA