Evaluating structure-based activity in a high-throughput assay for steroid biosynthesis

Human-relevant concentrations of the antifungal drug clotrimazole disrupts maternal and fetal steroid hormone profiles in rats

(2021) Monica Kam Draskau et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Organoids of the Female Reproductive Tract: Innovative Tools to Study Desired to Unwelcome Processes

(2021) Ruben Heremans et al.   Frontiers in Cell and Developmental Biology

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

(2020) Kamel Mansouri et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Organoid technology in female reproductive biomedicine

(2020) Heidar Heidari-Khoei et al.   Reproductive Biology and Endocrinology

The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency

(2019) Russell S Thomas et al.   TOXICOLOGICAL SCIENCES

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

(2019) Jun Wang et al.   ENVIRONMENT INTERNATIONAL

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

(2019) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

Development of a prioritization method for chemical-mediated effects on steroidogenesis using an integrated statistical analysis of high-throughput H295R data

(2019) Derik E. Haggard et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Integrated Approaches to Testing and Assessment: OECD Activities on the Development and Use of Adverse Outcome Pathways and Case Studies

(2018) Yuki Sakuratani et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The US Federal Tox21 Program: A strategic and operational plan for continued leadership

(2018) Russell Thomas   ALTEX-Alternatives to Animal Experimentation

OPERA models for predicting physicochemical properties and environmental fate endpoints

(2018) Kamel Mansouri et al.   Journal of Cheminformatics

Uncertainty quantification in ToxCast high throughput screening

(2018) Eric D. Watt et al.   PLoS One

Evaluation of androgen assay results using a curated Hershberger database

(2018) N.C. Kleinstreuer et al.   REPRODUCTIVE TOXICOLOGY

Development of a curated Hershberger database

(2018) P. Browne et al.   REPRODUCTIVE TOXICOLOGY

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

(2018) Eric Fabian et al.   ARCHIVES OF TOXICOLOGY

An Embryonic and Induced Pluripotent Stem Cell Model for Ovarian Granulosa Cell Development and Steroidogenesis

(2017) Shane Lipskind et al.   Reproductive Sciences

High-Throughput H295R Steroidogenesis Assay: Utility as an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis

(2017) Derik E Haggard et al.   TOXICOLOGICAL SCIENCES

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

(2017) Antony J. Williams et al.   Journal of Cheminformatics

Development and Validation of a Computational Model for Androgen Receptor Activity

(2016) Nicole C. Kleinstreuer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study

(2016) Katie Paul Friedman et al.   CRITICAL REVIEWS IN TOXICOLOGY

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

(2016) Kamel Mansouri et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information

(2016) Imran Shah et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells

(2016) Agnes L. Karmaus et al.   TOXICOLOGICAL SCIENCES

ClassyFire: automated chemical classification with a comprehensive, computable taxonomy

(2016) Yannick Djoumbou Feunang et al.   Journal of Cheminformatics

A Curated Database of Rodent Uterotrophic Bioactivity

(2015) Nicole C. Kleinstreuer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

New Publicly Available Chemical Query Language, CSRML, To Support Chemotype Representations for Application to Data Mining and Modeling

(2015) Chihae Yang et al.   Journal of Chemical Information and Modeling

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

Application of Mass Balance Models and the Chemical Activity Concept To Facilitate the Use of in Vitro Toxicity Data for Risk Assessment

(2014) James M. Armitage et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

More than just hormones: H295R cells as predictors of reproductive toxicity

(2014) Jodi M. Maglich et al.   REPRODUCTIVE TOXICOLOGY

Antiandrogenic Mechanisms of Pesticides in Human LNCaP Prostate and H295R Adrenocortical Carcinoma Cells

(2014) Christina N. Robitaille et al.   TOXICOLOGICAL SCIENCES

Integrative Chemical–Biological Read-Across Approach for Chemical Hazard Classification

(2013) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Propiconazole Inhibits Steroidogenesis and Reproduction in the Fathead Minnow (Pimephales promelas)

(2013) Sarah Y. Skolness et al.   TOXICOLOGICAL SCIENCES

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

BLTK1 Murine Leydig Cells: A Novel Steroidogenic Model for Evaluating the Effects of Reproductive and Developmental Toxicants

(2012) Agnes L. Forgacs et al.   TOXICOLOGICAL SCIENCES

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

Quantitative Correlation of Physical and Chemical Properties with Chemical Structure: Utility for Prediction

(2010) Alan R. Katritzky et al.   CHEMICAL REVIEWS

The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

(2010) Markus Hecker et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Computational Model of Steroidogenesis in Human H295R Cells toPredict Biochemical Response to Endocrine-Active Chemicals: Model Developmentfor Metyrapone

(2009) Michael S. Breen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Inhibition of Rat and Human Steroidogenesis by Triazole Antifungals

(2009) Amber K. Goetz et al.   Systems Biology in Reproductive Medicine

Mode of Action for Reproductive and Hepatic Toxicity Inferred from a Genomic Study of Triazole Antifungals

(2009) Amber K. Goetz et al.   TOXICOLOGICAL SCIENCES

Expression of progesterone and estradiol receptors in normal adrenal cortex, adrenocortical tumors, and primary pigmented nodular adrenocortical disease

(2008) P. de Cremoux et al.   ENDOCRINE-RELATED CANCER