Uncertainty quantification in ToxCast high throughput screening

Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring

(2016) Julia E. Rager et al.   ENVIRONMENT INTERNATIONAL

On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens

(2016) Amanda Shaine Janesick et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information

(2016) Imran Shah et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

(2016) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

Predicting Hepatotoxicity Using ToxCast in Vitro Bioactivity and Chemical Structure

(2015) Jie Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantitative high-throughput screening data analysis: challenges and recent advances

(2015) Keith R. Shockley   DRUG DISCOVERY TODAY

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

(2015) Imran Shah et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

Defining Estrogenic Mechanisms of Bisphenol A Analogs through High Throughput Microscopy-Based Contextual Assays

(2014) Fabio Stossi et al.   CHEMISTRY & BIOLOGY

Immediate and long-term consequences of vascular toxicity during zebrafish development

(2014) T.L. Tal et al.   REPRODUCTIVE TOXICOLOGY

Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

(2014) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

(2014) Ruili Huang et al.   Scientific Reports

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays

(2013) Nisha S. Sipes et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T-47D Human Ductal Carcinoma Cells

(2013) Daniel M. Rotroff et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality

(2013) Matias S. Attene-Ramos et al.   DRUG DISCOVERY TODAY

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

(2013) M. E. Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays

(2013) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

A Computational Model Predicting Disruption of Blood Vessel Development

(2013) Nicole Kleinstreuer et al.   PLoS Computational Biology

ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence

(2012) D. M. Reif et al.   BIOINFORMATICS

Statistical properties of an early stopping rule for resampling-based multiple testing

(2012) H. Jiang et al.   BIOMETRIKA

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Three-Stage Algorithm to Make Toxicologically Relevant Activity Calls from Quantitative High Throughput Screening Data

(2012) Keith R Shockley   ENVIRONMENTAL HEALTH PERSPECTIVES

Robust Analysis of High Throughput Screening (HTS) Assay Data

(2012) Changwon Lim et al.   TECHNOMETRICS

In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis

(2012) Nicole C. Kleinstreuer et al.   TOXICOLOGICAL SCIENCES

A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening

(2012) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Zebrafish-As an integrative model for twenty-first century toxicity testing

(2011) Nisha S. Sipes et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

(2011) Ruili Huang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Environmental Impact on Vascular Development Predicted by High-Throughput Screening

(2011) Nicole C. Kleinstreuer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Using Nuclear Receptor Activity to Stratify Hepatocarcinogens

(2011) Imran Shah et al.   PLoS One

Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

(2011) Kelly J. Chandler et al.   PLoS One

Mouse embryonic stem cell adherent cell differentiation and cytotoxicity (ACDC) assay

(2011) Marianne Barrier et al.   REPRODUCTIVE TOXICOLOGY

Zebrafish developmental screening of the ToxCast™ Phase I chemical library

(2011) S. Padilla et al.   REPRODUCTIVE TOXICOLOGY

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

(2011) Nisha S. Sipes et al.   TOXICOLOGICAL SCIENCES

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Quantification of Hormone Sensitive Lipase Phosphorylation and Colocalization with Lipid Droplets in Murine 3T3L1 and Human Subcutaneous Adipocytes via Automated Digital Microscopy and High-Content Analysis

(2010) Patrick M. McDonough et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

(2010) Sunita J. Shukla et al.   DRUG DISCOVERY TODAY

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The wild bootstrap, tamed at last

(2008) Russell Davidson et al.   JOURNAL OF ECONOMETRICS

Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

(2008) Robert J. Kavlock et al.   RISK ANALYSIS

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE