Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
G. Delbes, M. Blazquez, J. Fernandino, P. Grigorova, B. F. Hales, C. Metcalfe, L. Navarro-Martin, L. Parent, B. Robaire, A. Rwigemera, G. Van der Kraak, M. Wade, V Marlatt
Summary: Endocrine disrupting chemicals (EDCs) have been found to impact reproductive health, with early exposures during critical developmental stages having immediate effects on gonadal and reproductive tract development, as well as potential long-term effects on reproductive health in both males and females. Understanding the mechanisms regulating sex determination, differentiation, and gonadal development in fish and rodents has improved our understanding of how EDCs affect reproduction.
ENVIRONMENTAL RESEARCH
(2022)
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Jana Skerlova, Aram Ismail, Helena Lindstrom, Birgitta Sjodin, Bengt Mannervik, Pal Stenmark
Summary: Organotin compounds are highly toxic environmental pollutants that disrupt the normal functioning of the nervous and endocrine systems. They inhibit glutathione transferases, impeding detoxification and antioxidant functions. Structural studies show that organotin compounds block enzyme activity by forming strong bonds, providing insight into their toxic effects.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
ZhiChao Dang
Summary: Both AMA and LAGDA are used to detect thyroid-mediated modality and adversity based on morphological changes during thyroid hormone-dependent metamorphosis. The EU Guidance recommends their use for investigating the effects of thyroid hormone system disrupting chemicals. However, there is debate over the necessity of using LAGDA as a follow-up to positive AMA results. This study analyzes the similarities, differences, and sensitivity of these two assays in detecting TDCs.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Ruiqiu Zhang, Bailun Wang, Ling Li, Shengjie Li, Huizhu Guo, Pei Zhang, Yuqing Hua, Xueyan Cui, Yan Li, Yan Mu, Xin Huang, Xiao Li
Summary: In this study, a series of artificial intelligence models targeting endocrine-disrupting chemicals (EDCs) receptors, including the androgen receptor (AR), estrogen receptor (ER), and pregnane X receptor (PXR), were developed. The consensus models achieved good predictive results for validation sets with balanced accuracy values of 87.37%, 90.13%, and 79.21% for AR, ER, and PXR binding assays, respectively. Analysis of the physical-chemical properties suggested significant differences between EDCs and non-EDCs. Structural alerts that can indicate an EDC were identified and integrated into the web server SApredictor. These models and structural characteristics can provide useful tools and information in the discrimination and mechanistic understanding of EDCs in drug discovery and environmental risk assessment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Endocrinology & Metabolism
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen
Summary: Endocrine disrupting chemicals, particularly antiandrogenic EDCs, may impact male reproductive health, especially when exposed during fetal development at the sensitive 'masculinization programming window'.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Summary: Research has shown a possible association between obesity and endocrine-disrupting chemicals, which can interfere with energy metabolism and adipose tissue structure regulation. Early exposure to these chemicals may induce epigenetic modifications, making individuals susceptible to obesity and other diseases.
Article
Environmental Sciences
Sherly Antony, Sham Antony, Sharrel Rebello, Sandhra George, Devika T. Biju, R. Reshmy, Aravind Madhavan, Parameswaran Binod, Ashok Pandey, Raveendran Sindhu, Mukesh Kumar Awasthi
Summary: Endocrine Disrupting Chemicals (EDCs) pose a serious threat to the health and future of humans and the ecosystem. This review provides an overview of various EDCs, their toxic effects, and both conventional and modern remediation methods. The use of sustainable approaches like bioremediation has shown positive impacts in controlling EDC pollution.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Viviana Ramirez, Yolanda Galvez-Ontiveros, Pablo Jose Gonzalez-Domenech, Miguel Angel Baca, Lourdes Rodrigo, Ana Rivas
Summary: The study aimed to review limited literature on the effects of postnatal exposure to EDC on child neurodevelopment and behavior. While some research suggests a relationship between postnatal EDC exposure and adverse neurobehavioral outcomes in children, the underlying mechanisms of action remain unclear.
ENVIRONMENTAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Yan Yan, Fengjun Guo, Kexin Liu, Rixin Ding, Yichao Wang
Summary: Endocrine-disrupting chemicals (EDCs) are naturally occurring or artificial substances released into the environment. Humans are exposed to EDCs through ingestion, inhalation, and skin contact, and they are found in everyday household items. EDCs have negative effects on health, including cancer, cardiovascular risk, and reproductive disorders, and the placenta is particularly sensitive to their impact. This review evaluates the effects of various EDCs on placental development and function, identifies knowledge gaps, and guides future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Robin P. Peeters, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: This study investigated the association between concentrations of endocrine disrupting chemicals (EDCs) in urine and blood during pregnancy and serum human chorionic gonadotropin (hCG) concentrations. The results showed that higher exposure to bisphenol A was associated with lower hCG concentrations, while higher triclosan exposure was associated with higher hCG concentrations. Higher exposure to certain phthalates and polychlorinated biphenyls (PCBs) was also associated with lower hCG concentrations. These findings suggest that EDC exposure may have negative effects on placental hCG production and secretion, warranting further experimental studies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
V. L. Marlatt, S. Bayen, D. Castaneda-Cortes, G. Delbes, P. Grigorova, V. S. Langlois, C. J. Martyniuk, C. D. Metcalfe, L. Parent, A. Rwigemera, P. Thomson, G. Van der Kraak
Summary: This review summarizes the current knowledge of the impacts of EDCs on reproductive success in wildlife and humans, with a focus on retrospective assessment and laboratory-based experiments. The evidence suggests that anthropogenic chemicals negatively impact reproduction by altering endocrine system function, particularly in aquatic species. Similar effects are observed in mammalian wildlife and humans in epidemiological studies. Further research is needed on the implications of chemical exposures during development and the potential for long-term reproductive effects. Field-based observations and long-term population level studies are key to addressing knowledge gaps.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Qier Wu, Xavier Coumoul, Philippe Grandjean, Robert Barouki, Karine Audouze
Summary: This study used an integrative systems biology approach to explore the potential links between EDCs and COVID-19 severity, identifying several signaling pathways that may be dysregulated by EDCs and contribute to COVID-19 severity. The findings highlight possible connections between exposure to environmental chemicals and disease development, emphasizing the relevance of computational systems biology methods in understanding molecular mechanisms.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
C. D. Metcalfe, S. Bayen, M. Desrosiers, G. Munoz, S. Sauve, V Yargeau
Summary: Endocrine disrupting chemicals (EDCs) are a diverse group of chemicals that require sensitive and varied analytical methods to monitor their presence in the environment. Only environmental matrixes with a clear link to endocrine effects are included, and emerging methods and advanced instruments for sample preparation are also discussed.
ENVIRONMENTAL RESEARCH
(2022)