Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy

Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy

(2022) Zhou Zhu et al.   ACTA PHARMACOLOGICA SINICA

Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease

(2022) Xinjie Guan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models

(2022) Ashok Iyaswamy et al.   Redox Biology

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis

(2021) Panchanan Maiti et al.   Alzheimers Research & Therapy

Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases and Glioblastoma

(2021) Jaione Auzmendi-Iriarte et al.   Frontiers in Aging Neuroscience

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

(2021) Sravan Gopalkrishnashetty Sreenivasmurthy et al.   PHYTOMEDICINE

Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease

(2021) Ashok Iyaswamy et al.   PHYTOMEDICINE

HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights

(2021) Eugenia Passaro et al.   Cancers

Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity

(2020) Laetitia Francelle et al.   Scientific Reports

The mechanism of Hsp90-induced oligomerizaton of Tau

(2020) S. Weickert et al.   Science Advances

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

(2020) M. Catarina Silva et al.   Nature Communications

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease

(2020) Amy F. T. Arnsten et al.   Alzheimers & Dementia

New Insights Into Drug Discovery Targeting Tau Protein

(2020) Yoshiyuki Soeda et al.   Frontiers in Molecular Neuroscience

Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer’s Disease

(2019) Mar Cuadrado-Tejedor et al.   Frontiers in Aging Neuroscience

Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models

(2019) Heesun Choi et al.   AGING CELL

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

(2019) Ju‐Xian Song et al.   AGING CELL

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Humanin is an endogenous activator of chaperone-mediated autophagy

(2017) Zhenwei Gong et al.   JOURNAL OF CELL BIOLOGY

Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors

(2016) D. Diedrich et al.   CHEMICAL COMMUNICATIONS

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

(2016) Yang Hai et al.   Nature Chemical Biology

HDAC6 Regulates the Chaperone-Mediated Autophagy to Prevent Oxidative Damage in Injured Neurons after Experimental Spinal Cord Injury

(2016) Min Su et al.   Oxidative Medicine and Cellular Longevity

Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities

(2015) Mario M. Dorostkar et al.   ACTA NEUROPATHOLOGICA

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease

(2013) Jung Min Song et al.   EXPERIMENTAL NEUROLOGY

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

(2013) Claudia Simões-Pires et al.   Molecular Neurodegeneration

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

Autophagic/lysosomal dysfunction in Alzheimer’s disease

(2013) Miranda E Orr et al.   Alzheimers Research & Therapy

Loss of motor function in preclinical Alzheimer’s disease

(2011) Aron S Buchman et al.   Expert Review of Neurotherapeutics

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

(2011) Hiroki Takeuchi et al.   PLoS One

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY