The mechanism of Hsp90-induced oligomerizaton of Tau

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

(2019) Dailu Chen et al.   Nature Communications

Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

(2018) Yann Fichou et al.   CHEMICAL COMMUNICATIONS

Dancing with the Diva: Hsp90–Client Interactions

(2018) Martina Radli et al.   JOURNAL OF MOLECULAR BIOLOGY

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges

(2018) Marlène Martinho et al.   Scientific Reports

The entropic force generated by intrinsically disordered segments tunes protein function

(2018) Nicholas D. Keul et al.   NATURE

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

(2018) Javier Oroz et al.   Nature Communications

Fold or not to fold upon binding — does it really matter?

(2018) Monika Fuxreiter   CURRENT OPINION IN STRUCTURAL BIOLOGY

Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding

(2017) Marta Robotta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp90 activator Aha1 drives production of pathological tau aggregates

(2017) Lindsey B. Shelton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of Hsp90 to Tau Promotes a Conformational Change and Aggregation of Tau Protein

(2017) Elena Tortosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

A functional role for intrinsic disorder in the tau-tubulin complex

(2016) Ana M. Melo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fuzzy complexes: Specific binding without complete folding

(2015) Rashmi Sharma et al.   FEBS LETTERS

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau

(2015) Anna Pavlova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Compensatory Adaptations of Structural Dynamics in an Intrinsically Disordered Protein Complex

(2014) Dennis Kurzbach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

Cooperative Unfolding of Compact Conformations of the Intrinsically Disordered Protein Osteopontin

(2013) Dennis Kurzbach et al.   BIOCHEMISTRY

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

DEER Distance Measurements on Proteins

(2012) Gunnar Jeschke   Annual Review of Physical Chemistry

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

The global analysis of DEER data

(2012) Suzanne Brandon et al.   JOURNAL OF MAGNETIC RESONANCE

Identification of an Aggregation-Prone Structure of Tau

(2012) Shana Elbaum-Garfinkle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

(2012) Susanne Wegmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dead-time free measurement of dipole–dipole interactions between electron spins

(2011) M. Pannier et al.   JOURNAL OF MAGNETIC RESONANCE

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transient Protein-Protein Interactions: Structural, Functional, and Network Properties

(2010) James R. Perkins et al.   STRUCTURE

Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules

(2009) Daniela Fischer et al.   BIOCHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY