Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models

HDAC6 regulates thermogenesis of brown adipocytes through activating PKA to induce UCP1 expression

(2018) Suna Jung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Involvement of Post-Translational Modifications in Alzheimer’s Disease

(2018) Serena Marcelli et al.   Current Alzheimer Research

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

(2018) Liang Qiang et al.   CURRENT BIOLOGY

Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics

(2018) Dong Kyu Kim et al.   Molecular Neurodegeneration

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model

(2018) Sheng-Jun Fan et al.   Cell Death & Disease

Tubastatin A/ACY-1215 Improves Cognition in Alzheimer's Disease Transgenic Mice

(2018) Ling Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

(2017) Yari Carlomagno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why do so many clinical trials of therapies for Alzheimer's disease fail?

(2017) Roy M Anderson et al.   LANCET

The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

(2017) Jui-Heng Tseng et al.   Cell Reports

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

(2016) Peter Dongmin Sohn et al.   Molecular Neurodegeneration

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Autodeubiquitination Protects the Tumor Suppressor BAP1 from Cytoplasmic Sequestration Mediated by the Atypical Ubiquitin Ligase UBE2O

(2014) Nazar Mashtalir et al.   MOLECULAR CELL

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone

(2008) Mitul Sarkar et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY