Adult Hippocampal Neurogenesis in Alzheimer’s Disease: An Overview of Human and Animal Studies with Implications for Therapeutic Perspectives Aimed at Memory Recovery

Evidences for Adult Hippocampal Neurogenesis in Humans

(2021) Elena P. Moreno-Jiménez et al.   JOURNAL OF NEUROSCIENCE

Physical Exercise Training Improves Judgment and Problem-Solving and Modulates Serum Biomarkers in Patients with Alzheimer’s Disease

(2021) Joni Marcio de Farias et al.   MOLECULAR NEUROBIOLOGY

Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus

(2021) Gaia Scabia et al.   BRAIN BEHAVIOR AND IMMUNITY

Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission

(2020) Jie Zheng et al.   Cell Stem Cell

Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer’s Disease

(2020) Emanuela Rizzello et al.   Current Alzheimer Research

Unraveling human adult hippocampal neurogenesis

(2020) Miguel Flor-García et al.   Nature Protocols

Exercise benefits on Alzheimer’s disease: State-of-the-science

(2020) Pedro L. Valenzuela et al.   AGEING RESEARCH REVIEWS

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Bispecific Antibody Fragment Targeting APP and Inducing α-Site Cleavage Restores Neuronal Health in an Alzheimer’s Mouse Model

(2019) Ping He et al.   MOLECULAR NEUROBIOLOGY

The activated newborn neurons participate in enriched environment induced improvement of locomotor function in APP/PS1 mice

(2019) Hualong Wang et al.   Brain and Behavior

Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer’s Disease Model

(2019) Chia-Hsuan Fu et al.   Cell Reports

Adult hippocampal neurogenesis for systems consolidation of memory

(2019) Joseph I. Terranova et al.   BEHAVIOURAL BRAIN RESEARCH

Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers

(2019) Chiara Scopa et al.   CELL DEATH AND DIFFERENTIATION

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Human Adult Neurogenesis: Evidence and Remaining Questions

(2018) Gerd Kempermann et al.   Cell Stem Cell

Stereological Investigation of the Effects of Treadmill Running Exercise on the Hippocampal Neurons in Middle-Aged APP/PS1 Transgenic Mice

(2018) Fenglei Chao et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of physical activity on delayed memory measures in randomized controlled trials with nonclinical older, mild cognitive impairment, and dementia participants

(2018) Philip Gerard Gasquoine   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway

(2018) Hui Lei et al.   NEUROTOXICITY RESEARCH

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition

(2018) Fernando Bartolome et al.   Alzheimers Research & Therapy

Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice

(2018) Lianne Hoeijmakers et al.   Frontiers in Aging Neuroscience

Factors that influence adult neurogenesis as potential therapy

(2018) Belal Shohayeb et al.   Translational Neurodegeneration

Rapid stimulation of human dentate gyrus function with acute mild exercise

(2018) Kazuya Suwabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Activation of CB 2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease

(2017) Jiang Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acute moderate exercise improves mnemonic discrimination in young adults

(2017) Kazuya Suwabe et al.   HIPPOCAMPUS

Xanthoceraside modulates neurogenesis to ameliorate cognitive impairment in APP/PS1 transgenic mice

(2017) Lin Zhu et al.   Journal of Physiological Sciences

Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood

(2017) Christoph Anacker et al.   NATURE REVIEWS NEUROSCIENCE

Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP swe /PS1 dE9 transgenic mice: Effect of long-term treatment with paroxetine

(2017) Louise Ørum Olesen et al.   NEUROBIOLOGY OF DISEASE

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease

(2017) David Baglietto-Vargas et al.   Scientific Reports

Alzheimer’s disease, dementia, and stem cell therapy

(2017) Thomas Duncan et al.   Stem Cell Research & Therapy

Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice

(2017) Shao-Heng Li et al.   Frontiers in Neuroscience

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons

(2016) Liam J. Drew et al.   HIPPOCAMPUS

An 18-mer Peptide Derived from Prosaposin Ameliorates the Effects of Aβ1–42 Neurotoxicity on Hippocampal Neurogenesis and Memory Deficit in Mice

(2016) Hui-ling Gao et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain

(2016) Shiwei Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease

(2016) M. S. Unger et al.   MOLECULAR NEUROBIOLOGY

Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer′s disease mice

(2016) Peng Zhao et al.   Neural Regeneration Research

Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding

(2016) Nathan B. Danielson et al.   NEURON

Neurogenesis-mediated forgetting minimizes proactive interference

(2016) Jonathan R. Epp et al.   Nature Communications

Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein

(2016) Hongyu Pan et al.   Stem Cell Reports

Osthole Upregulates BDNF to Enhance Adult Hippocampal Neurogenesis in APP/PS1 Transgenic Mice

(2015) Hong Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Coumarin Derivative Osthole Stimulates Adult Neural Stem Cells, Promotes Neurogenesis in the Hippocampus, and Ameliorates Cognitive Impairment in APP/PS1 Transgenic Mice

(2015) Liang Kong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A novel phosphodiesterase-5 Inhibitor: Yonkenafil modulates neurogenesis, gliosis to improve cognitive function and ameliorates amyloid burden in an APP/PS1 transgenic mice model

(2015) Lei Zhu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease

(2015) Edward Rockenstein et al.   Stem Cell Research

Adult Neurogenesis in Humans

(2015) Olaf Bergmann et al.   Cold Spring Harbor Perspectives in Biology

Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer’s disease

(2014) Kevin Richetin et al.   BRAIN

The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons

(2014) B. Wang et al.   JOURNAL OF NEUROSCIENCE

Inhibitory Interneuron Progenitor Transplantation Restores Normal Learning and Memory in ApoE4 Knock-In Mice without or with A  Accumulation

(2014) L. M. Tong et al.   JOURNAL OF NEUROSCIENCE

Social Interaction Rescues Memory Deficit in an Animal Model of Alzheimer's Disease by Increasing BDNF-Dependent Hippocampal Neurogenesis

(2014) Ya-Hsin Hsiao et al.   JOURNAL OF NEUROSCIENCE

Protection of Radial Glial-Like Cells in the Hippocampus of APP/PS1 Mice: a Novel Mechanism of Memantine in the Treatment of Alzheimer’s Disease

(2014) Dayu Sun et al.   MOLECULAR NEUROBIOLOGY

Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer′s disease mice

(2014) Yandao Gong et al.   Neural Regeneration Research

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

(2014) K. G. Akers et al.   SCIENCE

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: Pathophysiological relevance for Alzheimer's disease?

(2013) Alexis Koutseff et al.   BRAIN RESEARCH

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction

(2013) Samuel O. Adeosun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice

(2013) S. Kanemoto et al.   NEUROSCIENCE

Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease

(2013) Alice Krezymon et al.   PLoS One

Bridging animal and human models of exercise-induced brain plasticity

(2013) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Adult neurogenesis modifies excitability of the dentate gyrus

(2013) Taruna Ikrar et al.   Frontiers in Neural Circuits

The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease

(2012) Alison Hamilton et al.   BRAIN RESEARCH

Functions of neurotrophins and growth factors in neurogenesis and brain repair

(2012) Sophia L. B. Oliveira et al.   CYTOMETRY PART A

TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function

(2012) M. P. Coba et al.   JOURNAL OF NEUROSCIENCE

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology

(2012) Elaine K. Perry et al.   NEUROBIOLOGY OF DISEASE

Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer’s Disease

(2012) Barbara Biscaro et al.   Neurodegenerative Diseases

Adult hippocampal neurogenesis and related neurotrophic factors

(2011) Eu-Gene Lee et al.   BMB Reports

ApoE is required for maintenance of the dentate gyrus neural progenitor pool

(2011) C.-P. Yang et al.   DEVELOPMENT

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

(2011) T Kiyota et al.   GENE THERAPY

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

The potential of functional MRI as a biomarker in early Alzheimer's disease

(2011) Reisa Sperling   NEUROBIOLOGY OF AGING

The Aging Hippocampus

(2011) Kirk I. Erickson et al.   NEUROSCIENTIST

Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APPSw,Ind Transgenic Mice

(2011) Jorge Valero et al.   PLoS One

Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice

(2011) B. H. Singer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

(2011) T. Kiyota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice

(2010) Tomomi Kiyota et al.   FASEB JOURNAL

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice

(2010) Yuan-Shih Hu et al.   FASEB JOURNAL

Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus

(2010) Clay O. Lacefield et al.   HIPPOCAMPUS

Adult-born neurons are necessary for extended contextual discrimination

(2010) Sophie Tronel et al.   HIPPOCAMPUS

Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis

(2010) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice

(2010) Michael Demars et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice

(2010) Marie-Caroline Cotel et al.   NEUROBIOLOGY OF AGING

Physical activity predicts gray matter volume in late adulthood: The Cardiovascular Health Study

(2010) K. I. Erickson et al.   NEUROLOGY

Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice

(2010) Anna Fiorentini et al.   PLoS One

Running enhances spatial pattern separation in mice

(2010) D. J. Creer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

(2010) J. M. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer Disease

(2009) Robyn A. Honea et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Signaling in Adult Neurogenesis

(2009) Hoonkyo Suh et al.   Annual Review of Cell and Developmental Biology

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

(2009) Binggui Sun et al.   Cell Stem Cell

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

Adult Neurogenesis Is Altered by GABAergic Imbalance in Models of Alzheimer's Disease

(2009) Alejandro F. Schinder et al.   Cell Stem Cell

Transgenic expression of human wild-type amyloid precursor protein decreases neurogenesis in the adult hippocampus

(2009) Nicole Naumann et al.   HIPPOCAMPUS

Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease

(2009) A. Faure et al.   NEUROBIOLOGY OF AGING

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

(2009) C. D. Clelland et al.   SCIENCE

Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory

(2009) Hyoung-Gon Ko et al.   Molecular Brain

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia

(2008) Emanuele Cacci et al.   GLIA

Cardiorespiratory fitness and brain atrophy in early Alzheimer disease

(2008) J. M. Burns et al.   NEUROLOGY

Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation

(2008) Se Hoon Choi et al.   NEURON

Adult neurogenesis is functionally associated with AD-like neurodegeneration

(2007) Qian Chen et al.   NEUROBIOLOGY OF DISEASE