Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s disease

Beneficial Effect of a CNTF Tetrapeptide on Adult Hippocampal Neurogenesis, Neuronal Plasticity, and Spatial Memory in Mice

(2017) Julie Blanchard et al.   JOURNAL OF ALZHEIMERS DISEASE

Accelerating stem cell trials for Alzheimer's disease

(2016) Joshua G Hunsberger et al.   LANCET NEUROLOGY

Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles

(2016) Marçal Vilar et al.   Frontiers in Neuroscience

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders

(2016) Chaoyang Liu et al.   Translational Neurodegeneration

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study

(2015) Leanne M. Stevens et al.   BEHAVIOURAL BRAIN RESEARCH

Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies

(2015) Sarah Pasquin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Enhancement of Neurogenesis and Memory by a Neurotrophic Peptide in Mild to Moderate Traumatic Brain Injury

(2015) Muhammad Omar Chohan et al.   NEUROSURGERY

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

(2015) Djoher Nora Abrous et al.   Cold Spring Harbor Perspectives in Biology

Nerve Growth Factor Gene Therapy

(2015) Mark H. Tuszynski et al.   JAMA Neurology

Sera from Children with Autism Induce Autistic Features Which Can Be Rescued with a CNTF Small Peptide Mimetic in Rats

(2015) Syed Faraz Kazim et al.   PLoS One

Lenti-GDNF Gene Therapy Protects Against Alzheimer's Disease-Like Neuropathology in 3xTg-AD Mice and MC65 Cells

(2014) Susana Revilla et al.   CNS Neuroscience & Therapeutics

Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor

(2014) Xia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of GDNF Receptor GFR 1 in Alzheimer's Neurons Results in Neuronal Death

(2014) Y. Konishi et al.   JOURNAL OF NEUROSCIENCE

Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer disease and related neurodegenerative conditions

(2014) Khalid Iqbal et al.   Neural Regeneration Research

Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound

(2014) Silvia Bolognin et al.   NEUROBIOLOGY OF AGING

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

(2014) Syed Faraz Kazim et al.   NEUROBIOLOGY OF DISEASE

Isolating Pathogenic Mechanisms Embedded within the Hippocampal Circuit through Regional Vulnerability

(2014) Scott A. Small   NEURON

Genetics of Alzheimer’s Disease

(2014) Rita Guerreiro et al.   Neurotherapeutics

7,8-Dihydroxyflavone, a Small Molecule TrkB Agonist, Improves Spatial Memory and Increases Thin Spine Density in a Mouse Model of Alzheimer Disease-Like Neuronal Loss

(2014) Nicholas A. Castello et al.   PLoS One

A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

(2014) Danielle A. Simmons et al.   PLoS One

Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome

(2014) M. Florencia Iulita et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

Episodic-like memory is sensitive to both Alzheimer's-like pathological accumulation and normal ageing processes in mice

(2013) Katherine E. Davis et al.   BEHAVIOURAL BRAIN RESEARCH

Small Molecules Activating TrkB Receptor for Treating a Variety of CNS Disorders

(2013) Yan Zeng et al.   CNS & Neurological Disorders-Drug Targets

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model

(2013) Juliet K. Knowles et al.   NEUROBIOLOGY OF AGING

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Zhentao Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures

(2013) Maria del Carmen Cardenas-Aguayo et al.   PLoS One

7,8-Dihydroxyflavone Ameliorates Scopolamine-Induced Alzheimer-Like Pathologic Dysfunction

(2013) Chong Chen et al.   REJUVENATION RESEARCH

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuropoietic cytokines in normal brain development and neurodevelopmental disorders

(2012) H.B. Stolp   MOLECULAR AND CELLULAR NEUROSCIENCE

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide

(2011) Silvia Bolognin et al.   ACTA NEUROPATHOLOGICA

Opportunities and challenges in developing Alzheimer disease therapeutics

(2011) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Neuroregeneration in neurodegenerative disorders

(2011) Ana M Enciu et al.   BMC Neurology

Adult neurogenesis and modulation of neural circuit function

(2011) Kaoru Inokuchi   CURRENT OPINION IN NEUROBIOLOGY

Adult neurogenesis in mammals - a theme with many variations

(2011) Luca Bonfanti et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rescue of Synaptic Failure and Alleviation of Learning and Memory Impairments in a Trisomic Mouse Model of Down Syndrome

(2011) Julie Blanchard et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

Ligand-Dependent TrkA Activity in Brain Differentially Affects Spatial Learning and Long-Term Memory

(2011) T. Aboulkassim et al.   MOLECULAR PHARMACOLOGY

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

(2011) B. DaRocha-Souto et al.   NEUROBIOLOGY OF DISEASE

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

(2011) T. Kiyota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice

(2010) Julie Blanchard et al.   ACTA NEUROPATHOLOGICA

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Alzheimer's disease, a multifactorial disorder seeking multitherapies

(2010) Khalid Iqbal et al.   Alzheimers & Dementia

Neurogenesis in the aged and neurodegenerative brain

(2010) Adi Shruster et al.   APOPTOSIS

Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice

(2010) Bin Li et al.   FEBS LETTERS

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease

(2010) P. Garcia et al.   JOURNAL OF NEUROSCIENCE

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice

(2010) Michael Demars et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons

(2010) Yuanyuan Ji et al.   NATURE NEUROSCIENCE

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice

(2010) Sung-Wuk Jang et al.   PLoS One

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

(2010) J. M. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-acetylserotonin activates TrkB receptor in a circadian rhythm

(2010) Sung-Wuk Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult neurogenesis: integrating theories and separating functions

(2010) James B. Aimone et al.   TRENDS IN COGNITIVE SCIENCES

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain

(2009) W. Deng et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide

(2009) Muhammad Omar Chohan et al.   NEUROBIOLOGY OF AGING

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Stem Cells to Grandmother Cells: How Neurogenesis Relates to Learning and Memory

(2008) Tracey J. Shors   Cell Stem Cell

Genetic aspects of Alzheimer disease

(2008) Thomas D Bird   GENETICS IN MEDICINE

Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus

(2008) Bin Li et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ciliary Neurotrophic Factor Mediates Dopamine D2 Receptor-Induced CNS Neurogenesis in Adult Mice

(2008) P. Yang et al.   JOURNAL OF NEUROSCIENCE

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

(2008) Marlen Knobloch et al.   MOLECULAR NEUROBIOLOGY

Neuropsychological Contributions to the Early Identification of Alzheimer’s Disease

(2008) Mark W. Bondi et al.   NEUROPSYCHOLOGY REVIEW

Spatial Relational Memory Requires Hippocampal Adult Neurogenesis

(2008) David Dupret et al.   PLoS One

Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

(2008) Tao Yang et al.   PLoS One

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

(2007) Yuan Lu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY