Proteolytic modulation of tumor microenvironment signals during cancer progression

Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells

(2022) Valentina Gifford et al.   MATRIX BIOLOGY

Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling

(2021) Chengxiao Hu et al.   Cell Death & Disease

ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration

(2021) Sofia K. H. Morsing et al.   Cells

Key Matrix Remodeling Enzymes: Functions and Targeting in Cancer

(2021) Zoi Piperigkou et al.   Cancers

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

(2021) Timo Burster et al.   Frontiers in Chemistry

Modulation of Microenvironment Signals by Proteolytic Shedding of Cell Surface Extracellular Matrix Receptors

(2021) Yoshifumi Itoh   Frontiers in Cell and Developmental Biology

A critical role for plasminogen in inflammation

(2020) Sarah K. Baker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

(2020) Sylvie Brassart-Pasco et al.   Frontiers in Oncology

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

(2020) Nina Marie Pedersen et al.   JOURNAL OF CELL BIOLOGY

Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia

(2020) Anna Zagryazhskaya-Masson et al.   JOURNAL OF CELL BIOLOGY

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms

(2019) Valentina Gifford et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Thrombin-cleaved syndecan-3/-4 ectodomain fragments mediate endothelial barrier dysfunction

(2019) Melanie Jannaway et al.   PLoS One

IL-1 Family Members in Cancer; Two Sides to Every Story

(2019) Kevin J. Baker et al.   Frontiers in Immunology

Extracellular matrix: key structural and functional meshwork in health and disease

(2019) Nikos K. Karamanos   FEBS Journal

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

(2019) Robin Ferrari et al.   Nature Communications

SNX27–retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis

(2019) Priyanka Sharma et al.   JOURNAL OF CELL BIOLOGY

The biology and role of CD44 in cancer progression: therapeutic implications

(2018) Chen Chen et al.   Journal of Hematology & Oncology

Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

(2018) Vasiliki Gkretsi et al.   Frontiers in Oncology

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

(2018) Nikos K. Karamanos et al.   MATRIX BIOLOGY

Invadosomes are coming: new insights into function and disease relevance

(2017) Elyse K. Paterson et al.   FEBS Journal

Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

(2017) Victoria Juskaite et al.   eLife

Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion

(2016) Antonio Castro-Castro et al.   Annual Review of Cell and Developmental Biology

Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein

(2015) N. Koshikawa et al.   CANCER RESEARCH

ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion

(2015) Valentina Marchesin et al.   JOURNAL OF CELL BIOLOGY

Membrane-type matrix metalloproteinases: Their functions and regulations

(2015) Yoshifumi Itoh   MATRIX BIOLOGY

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)

(2015) Yasuyuki Shitomi et al.   MOLECULAR BIOLOGY OF THE CELL

Matrikines from basement membrane collagens: A new anti-cancer strategy

(2014) Jean Claude Monboisse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MT-LOOP-dependent Localization of Membrane Type I Matrix Metalloproteinase (MT1-MMP) to the Cell Adhesion Complexes Promotes Cancer Cell Invasion

(2013) Anna M. Woskowicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases

(2013) Hsueh-Liang Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

(2013) Nami Sugiyama et al.   JOURNAL OF CELL BIOLOGY

Laminin 332 processing impacts cellular behavior

(2013) Patricia Rousselle et al.   Cell Adhesion & Migration

LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro

(2012) Stephanie Ghislin et al.   BMC CANCER

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

p53 Inhibits Angiogenesis by Inducing the Production of Arresten

(2012) S. Assadian et al.   CANCER RESEARCH

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

(2012) Yu Wang et al.   JOURNAL OF CELL BIOLOGY

The matrix metalloproteinase-7 regulates the extracellular shedding of syndecan-2 from colon cancer cells

(2011) Sojoong Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer

(2011) Yoshifumi Itoh et al.   BIOCHEMICAL JOURNAL

The action of neutrophil serine proteases on elastin and its precursor

(2011) Andrea Heinz et al.   BIOCHIMIE

EphA2-Dependent Molecular Targeting Therapy for Malignant Tumors

(2011) RONG Biao-xue et al.   CURRENT CANCER DRUG TARGETS

Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148

(2011) James R. Whiteford et al.   MOLECULAR BIOLOGY OF THE CELL

Matrix metalloproteinase-7 activates heparin-binding epidermal growth factor-like growth factor in cutaneous squamous cell carcinoma

(2010) A.K. Kivisaari et al.   BRITISH JOURNAL OF DERMATOLOGY

Membrane Type 1-Matrix Metalloproteinase Cleaves Off the NH2-Terminal Portion of Heparin-Binding Epidermal Growth Factor and Converts It into a Heparin-Independent Growth Factor

(2010) N. Koshikawa et al.   CANCER RESEARCH

Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src

(2010) Katherine Kun Lu et al.   CARDIOVASCULAR PATHOLOGY

Proteoglycans in health and disease: the multiple roles of syndecan shedding

(2010) Tina Manon-Jensen et al.   FEBS Journal

Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines

(2010) Andrea Heinz et al.   FEBS Journal

Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1

(2010) Huifang Xu et al.   MATRIX BIOLOGY

Binding to the Extracellular Matrix and Proteolytic Processing: Two Key Mechanisms Regulating Vascular Endothelial Growth Factor Action

(2010) Napoleone Ferrara   MOLECULAR BIOLOGY OF THE CELL

Elevation of Receptor Tyrosine Kinase EphA2 Mediates Resistance to Trastuzumab Therapy

(2009) G. Zhuang et al.   CANCER RESEARCH

MT2-MMP-Dependent Release of Collagen IV NC1 Domains Regulates Submandibular Gland Branching Morphogenesis

(2009) Ivan T. Rebustini et al.   DEVELOPMENTAL CELL

A Disintegrin and Metalloproteinase 17 (ADAM17) Mediates Inflammation-induced Shedding of Syndecan-1 and -4 by Lung Epithelial Cells

(2009) Jessica Pruessmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia

(2009) R. Poincloux et al.   JOURNAL OF CELL SCIENCE

MMP7 Shedding of Syndecan-1 Facilitates Re-Epithelialization by Affecting α2β1 Integrin Activation

(2009) Peter Chen et al.   PLoS One

MT1-MMP releases latent TGF-β1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1

(2008) O TATTI et al.   EXPERIMENTAL CELL RESEARCH

Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion

(2008) Juan Carlos Rodríguez-Manzaneque et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Second Dimer Interface of MT1-MMP, the Transmembrane Domain, Is Essential for ProMMP-2 Activation on the Cell Surface

(2008) Yoshifumi Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of High Affinity Binding Motifs for the Discoidin Domain Receptor DDR2 in Collagen

(2008) Antonios D. Konitsiotis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10 Is the Constitutive Functional Sheddase of CD44 in Human Melanoma Cells

(2008) Ulf Anderegg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pervanadate-induced shedding of the intercellular adhesion molecule (ICAM)-1 ectodomain is mediated by membrane type-1 matrix metalloproteinase (MT1-MMP)

(2008) E. Essick et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

(2008) Gillian Murphy et al.   Nature clinical practice. Rheumatology

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE