Systematic Metabolic Profiling Identifies De Novo Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation

GNP2 Encodes a High-Specificity Proline Permease in Candida albicans

(2022) Enrico Garbe et al.   mBio

Transcriptional Control of Hypoxic Hyphal Growth in the Fungal Pathogen Candida albicans

(2022) Manon Henry et al.   Frontiers in Cellular and Infection Microbiology

Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools

(2021) Nathaniel L. Hepowit et al.   Aging-US

Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans

(2021) Kyunghun Min et al.   PLoS Pathogens

Functions of Sphingolipids in Pathogenesis During Host–Pathogen Interactions

(2021) Jian Wang et al.   Frontiers in Microbiology

The Regulatory Proteins Rtg1/3 Govern Sphingolipid Homeostasis in the Human-Associated Yeast Candida albicans

(2020) Sergio D. Moreno-Velásquez et al.   Cell Reports

Metabolic Reprogramming in the Opportunistic Yeast Candida albicans in Response to Hypoxia

(2020) Anaïs Burgain et al.   mSphere

Carboxylic Acid Transporters in Candida Pathogenesis

(2020) Rosana Alves et al.   mBio

Fungal sphingolipids: role in the regulation of virulence and potential as targets for future antifungal therapies

(2020) Caroline Mota Fernandes et al.   Expert Review of Anti-Infective Therapy

Catch the wave: Metabolomic analyses in human pathogenic fungi

(2020) Philipp Brandt et al.   PLoS Pathogens

The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans

(2019) Adnane Sellam et al.   PLoS Genetics

Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans

(2019) Fitz Gerald S. Silao et al.   PLoS Genetics

A metabolomic study of the effect of Candida albicans glutamate dehydrogenase deletion on growth and morphogenesis

(2019) Ting-Li Han et al.   npj Biofilms and Microbiomes

Methionine is required for cAMP-PKA-mediated morphogenesis and virulence of Candida albicans

(2018) Sanne Schrevens et al.   MOLECULAR MICROBIOLOGY

Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi

(2018) Caroline Mota Fernandes et al.   mBio

The glycerophosphocholine acyltransferase Gpc1 is part of a phosphatidylcholine (PC)-remodeling pathway that alters PC species in yeast

(2018) Sanket Anaokar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi

(2017) Laure Nicolas Annick Ries et al.   MOLECULAR MICROBIOLOGY

A feast for Candida: Metabolic plasticity confers an edge for virulence

(2017) Pedro Miramón et al.   PLoS Pathogens

Sphingolipids as targets for treatment of fungal infections

(2016) Rodrigo Rollin-Pinheiro et al.   Future Medicinal Chemistry

Hgc1-Cdc28–how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?

(2016) Yue Wang   JOURNAL OF MICROBIOLOGY

Making Sense of the Yeast Sphingolipid Pathway

(2016) Márton Megyeri et al.   JOURNAL OF MOLECULAR BIOLOGY

Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis

(2016) Nicolas Lebesgue et al.   JOURNAL OF PROTEOME RESEARCH

A functional link between hyphal maintenance and quorum sensing inCandida albicans

(2016) Melanie Polke et al.   MOLECULAR MICROBIOLOGY

Candidalysin is a fungal peptide toxin critical for mucosal infection

(2016) David L. Moyes et al.   NATURE

Candida albicans cell-type switching and functional plasticity in the mammalian host

(2016) Suzanne M. Noble et al.   NATURE REVIEWS MICROBIOLOGY

TheCandidaGenome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data

(2016) Marek S. Skrzypek et al.   NUCLEIC ACIDS RESEARCH

Characterization of the Candida albicans Amino Acid Permease Family: Gap2 Is the Only General Amino Acid Permease and Gap4 Is an S -Adenosylmethionine (SAM) Transporter Required for SAM-Induced Morphogenesis

(2016) Lucie Kraidlova et al.   mSphere

Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1

(2015) Neha Chauhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ward’s Hierarchical Agglomerative Clustering Method: Which Algorithms Implement Ward’s Criterion?

(2014) Fionn Murtagh et al.   JOURNAL OF CLASSIFICATION

Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels

(2014) Alistair J.P. Brown et al.   TRENDS IN MICROBIOLOGY

Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant

(2014) Anja Wartenberg et al.   PLoS Genetics

Structural diversity and biological significance of glycosphingolipids in pathogenic and opportunistic fungi

(2014) Luciana L. Guimarães et al.   Frontiers in Cellular and Infection Microbiology

Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

(2013) Akio Kihara   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Core Filamentation Response Network in Candida albicans Is Restricted to Eight Genes

(2013) Ronny Martin et al.   PLoS One

Candida albicanspathogenicity mechanisms

(2013) François L. Mayer et al.   Virulence

Candida albicans Induces Arginine Biosynthetic Genes in Response to Host-Derived Reactive Oxygen Species

(2012) Claudia Jiménez-López et al.   EUKARYOTIC CELL

Normal Adaptation of Candida albicans to the Murine Gastrointestinal Tract Requires Efg1p-Dependent Regulation of Metabolic and Host Defense Genes

(2012) Jessica V. Pierce et al.   EUKARYOTIC CELL

The metabolic response ofCandida albicansto farnesol under hyphae-inducing conditions

(2012) Ting-Li Han et al.   FEMS YEAST RESEARCH

Metabolome analysis during the morphological transition of Candida albicans

(2012) Ting-li Han et al.   Metabolomics

Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress-mediated mitochondrial apoptosis in budding yeast

(2012) Kentaro Kajiwara et al.   MOLECULAR MICROBIOLOGY

The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast Candida albicans

(2012) D. Sandai et al.   mBio

Nutrient acquisition by pathogenic fungi: Nutrient availability, pathway regulation, and differences in substrate utilization

(2011) Christian B. Fleck et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans

(2011) Seon Ah Cheon et al.   MOLECULAR MICROBIOLOGY

Growth of Candida albicans hyphae

(2011) Peter E. Sudbery   NATURE REVIEWS MICROBIOLOGY

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

(2011) Neil A. R. Gow et al.   NATURE REVIEWS MICROBIOLOGY

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Pathway Activity Profiling (PAPi): from the metabolite profile to the metabolic pathway activity

(2010) Raphael B. M. Aggio et al.   BIOINFORMATICS

Comprehensive annotation of the transcriptome of the human fungal pathogen Candida albicans using RNA-seq

(2010) V. M. Bruno et al.   GENOME RESEARCH

Disruption of sphingolipid biosynthetic geneIPT1reducesCandida albicansadhesion and prevents activation of human gingival epithelial cell innate immune defense

(2010) Mahmoud Rouabhia et al.   MEDICAL MYCOLOGY

Membranes in Balance: Mechanisms of Sphingolipid Homeostasis

(2010) David K. Breslow et al.   MOLECULAR CELL

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

(2010) Suzanne M Noble et al.   NATURE GENETICS

Organization of GC/MS and LC/MS metabolomics data into chemical libraries

(2010) Corey D DeHaven et al.   Journal of Cheminformatics

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

(2009) Anne M. Evans et al.   ANALYTICAL CHEMISTRY

Fungal metabolism in host niches

(2009) Matthias Brock   CURRENT OPINION IN MICROBIOLOGY

SLA2 mutations cause SWE1-mediated cell cycle phenotypes in Candida albicans and Saccharomyces cerevisiae

(2009) C. A. Gale et al.   MICROBIOLOGY-SGM

Candida albicans sphingolipid C9-methyltransferase is involved in hyphal elongation

(2009) T. Oura et al.   MICROBIOLOGY-SGM

Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides

(2009) Vanessa Cerantola et al.   MOLECULAR MICROBIOLOGY

MetaboAnalyst: a web server for metabolomic data analysis and interpretation

(2009) J. Xia et al.   NUCLEIC ACIDS RESEARCH

Functional Mapping of theCandida albicansEfg1 Regulator

(2008) Christine S. Noffz et al.   EUKARYOTIC CELL

Thematic Review Series: Sphingolipids. ISC1(inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases

(2008) Nabil Matmati et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Sphingolipids.New insights into sphingolipid metabolism and function in budding yeast

(2008) Robert C. Dickson   JOURNAL OF LIPID RESEARCH