Review
Plant Sciences
Linhui Yu, Chao Zhou, Jilian Fan, John Shanklin, Changcheng Xu
Summary: Lipid remodeling, defined as post-synthetic modifications of membrane lipids, plays a crucial role in regulating cellular membrane properties and functions. Processes affected by lipid remodeling include lipid metabolism, membrane repair, cellular homeostasis, fatty acid trafficking, cellular signaling, and stress tolerance. Recent research focuses on understanding the mechanisms of membrane lipid remodeling, particularly the enzymes involved in modifying major membrane lipids such as phosphatidylcholine and monogalactosyldiacylglycerol.
Article
Plant Sciences
Xiaomin Ji, Xiaoyue Wu, Wei Chen, Qianhui Yuan, Yixin Shen, Yingjun Chi
Summary: Phosphoethanolamine methyltransferase (PEAMT) plays a crucial role in various biological processes in plants, with GmPEAMT1 and GmPEAMT2 in soybean possibly involved in plant stress response. The study shows that GmPEAMTs can catalyze the methylation of phosphoethanolamine, restoring normal growth and root phenotype in plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Zhenhua Wang, Meng Yang, Yufan Yang, Yonglin He, Hongwu Qian
Summary: This study presents the cryo-EM structures of human CEPT1 and its complex with CDP-choline, revealing a hydrophobic chamber involved in catalysis. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are vital components of eukaryotic membranes and have various important roles. The structures of CEPT1 and its complex provide insights into the catalytic mechanism and potential substrate-triggered product release.
NATURE COMMUNICATIONS
(2023)
Review
Plant Sciences
Shengnan Zhu, Cuiyue Liang, Jiang Tian, Yingbin Xue
Summary: This review summarizes recent discoveries and molecular basis of plant adaptive mechanisms to low phosphate availability, providing insights into the molecular mechanisms underlying plant adaptation to phosphorus starvation and facilitating the development of crop cultivars with high phosphorus utilization efficiency.
Article
Fisheries
Hanying Xu, Teng Liu, Wenping Feng, Jiale He, Tao Han, Jiteng Wang, Chunlin Wang
Summary: This study investigated the effects of dietary phosphatidylcholine/soybean lecithin (PC/SL) levels on the survival, growth, body composition, antioxidant capacity, and osmoregulation ability of early juvenile mud crab Scylla paramamosain. The results showed that the appropriate levels of PC and SL had positive effects on the performance and physiological indices of the crabs.
Article
Biochemistry & Molecular Biology
Danielle Defries, Kayla Curtis, Jay C. Petkau, Shiva Shariati-Ievari, Heather Blewett, Michel Aliani
Summary: After treatment with ALA, the incorporation of ALA into phospholipids is selective, with certain molecular species of phospholipids increasing almost immediately while others only increasing after several hours.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Immunology
Renata de Freitas Saito, Luciana Nogueira de Sousa Andrade, Silvina Odete Bustos, Roger Chammas
Summary: This review highlights the role of phosphatidylcholine metabolism in cancer therapy resistance, from intracellular processes to cellular communication within the tumor microenvironment, providing new insights for treating drug-resistant cancers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Zhideng Lin, Xianyong Bu, Nan Wang, Yong Lei, Shubin Liu, Xiaodan Wang, Zhimin Gu, Zhenyu Du, Jianguang Qin, Liqiao Chen
Summary: The study showed that high dietary phospholipid can reduce excessive lipid deposition in the hepatopancreas of Eriocheir sinensis juveniles by promoting lipid oxidation and exportation, and inhibiting lipid absorption and synthesis. This optimization of lipid metabolism improves growth performance and lipid utilization in the crabs.
Article
Biochemistry & Molecular Biology
Thibaut Bourgeois, Antoine Jalil, Charles Thomas, Charlene Magnani, Naig Le Guern, Thomas Gautier, Jean-Paul Pais de Barros, Victoria Bergas, Helene Choubley, Loic Mazzeo, Louise Menegaut, Lorene Josiane Lebrun, Kevin Van Dongen, Marion Xolin, Tony Jourdan, Chloe Buch, Jerome Labbe, Philippe Saas, Laurent Lagrost, David Masson, Jacques Grober
Summary: Recent studies have found that LPCAT3 plays an important role in controlling the PUFA composition of cell membranes in the liver and intestine, but its role in macrophages remains controversial. Partial LPCAT3 deficiency in macrophages alters the PUFA composition of phospholipid subclasses and reduces cholesterol efflux, but does not impact inflammatory response or ER stress. Ultimately, myeloid LPCAT3 deficiency may affect AA homeostasis in the liver, leading to metabolic disorders and triglyceride accumulation.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Agronomy
Zhanyu Chen, Yushuang Wang, Yanbo Chen, Xiaoqin Yang, Shuang Wang, Tingting Yu, Ying Zhou, Xiyan Cui
Summary: This study characterized the molecular properties of GmPLMT and its effects on lipid metabolites in soybeans. The expression patterns of GmPLMT varied in different growth stages of soybeans and transgenic Arabidopsis thaliana seeds, affecting the production of lipid metabolites. Increased expression of GmPLMT was positively correlated with higher levels of PtdCho and crude fats, suggesting its potential for enhancing lipid metabolite production in soybeans.
Article
Nutrition & Dietetics
Anthea Van Parys, Maria Sandvik Braekke, Therese Karlsson, Kathrine J. Vinknes, Grethe S. Tell, Teresa R. Haugsgjerd, Per Magne Ueland, Jannike Oyen, Jutta Dierkes, Ottar Nygard, Vegard Lysne
Summary: This study investigated the dietary intake of choline and its association with one-carbon metabolites and lipids in community-dwelling adults in Norway. The findings suggest that choline intake is correlated with the concentration of most metabolites involved in one-carbon and lipid metabolism.
JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Karin Athenstaedt
Summary: Phosphatidic acid biosynthesis is the key process in glycerolipid metabolism, involving two consecutive acylation reactions. Yeast and mammals have additional pathways for phosphatidic acid synthesis. Further research is needed to understand this biosynthesis process and the entire lipid metabolic network.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Agriculture, Multidisciplinary
Xincen Wang, Qinsheng Chen, Xiaoxu Wang, Peixu Cong, Jie Xu, Changhu Xue
Summary: Ether-phospholipids in sea urchins, particularly PE-P and PC-O, have potential lipid-regulating effects in high-fat-induced atherosclerotic hamsters. PE-P is more effective than PC-O in decreasing total cholesterol and LDL cholesterol concentrations in serum. These lipid effects may be attributed to modulation of lipid metabolism and regulation of gene expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Nutrition & Dietetics
Zhanpeng Su, Zhixian Zong, Jinxia Deng, Jianping Huang, Guihua Liu, Bo Wei, Liao Cui, Gang Li, Huan Zhong, Sien Lin
Summary: Lipids have a diverse impact on cartilage growth, injury, and regeneration. Lipid metabolism is a complex process that affects different aspects of cartilage. Proper lipid supplementation can help preserve cartilage function, while excessive lipid buildup is detrimental. Understanding the role of lipid metabolism in cartilage metabolism can lead to the development of new treatment techniques for metabolic cartilage damage.
Article
Biochemistry & Molecular Biology
Christelle F. Ancajas, Shahrina Alam, Daiane S. Alves, Yue Zhou, Nicholas M. Wadsworth, Chelsi D. Cassilly, Tanei J. Ricks, Adam J. Carr, Todd B. Reynolds, Francisco N. Barrera, Michael D. Best
Summary: Phosphatidylserine (PS) is a crucial lipid involved in disease-related biological processes. In this study, we demonstrate a method for tracking PS in live Saccharomyces cerevisiae cells using derivatized analogues of serine. These compounds incorporate into lipid biosynthetic pathways and produce tagged PS molecules, enabling imaging using fluorescent reporters. This approach offers great potential for studying the biosynthesis and trafficking pathways of PS.
ACS CHEMICAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jana Patton-Vogt, Anton I. P. M. de Kroon
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Biochemistry & Molecular Biology
Grzegorz Pawlik, Mike F. Renne, Matthijs A. Kol, Anton I. P. M. de Kroon
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Letter
Biotechnology & Applied Microbiology
Mike F. Renne, Xue Bao, Anton I. P. M. de Kroon
FEMS YEAST RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Xuefeng Cao, Jos F. H. M. Brouwers, Linda van Dijk, Chris H. A. van de Lest, Craig T. Parker, Steven Huynh, Jos P. M. van Putten, David J. Kelly, Marc M. S. M. Wosten
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Michiel L. Bexkens, Renske A. van Gestel, Bas van Breukelen, Rolf T. Urbanus, Jos F. Brouwers, Rienk Nieuwland, Aloysius G. M. Tielens, Jaap J. van Hellemond
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mingjuan Li, M. Ingmar van Raath, Shervin Khakpour, Ahmet Secilir, Bart C. Sliggers, Xuan Huang, Baoyue Ding, Gert Storm, Rene R. van der Hulst, Anton I. P. M. de Kroon, Michal Heger
Article
Cell Biology
Helena Xicoy, Jos F. Brouwers, Be Wieringa, Gerard J. M. Martens
Article
Chemistry, Applied
Daylan A. Tzompa-Sosa, Koen Dewettinck, Paul Provijn, Jos F. Brouwers, Bruno de Meulenaer, Dennis G. A. B. Oonincx
Summary: The study analyzed the lipid composition differences among four species of crickets and found that two-spotted and banded crickets had higher lipid content than house crickets. The lipids in these crickets were high in UFA and unsaturated TAG, making them liquid at room temperature. High levels of cholesterol and various phytosterols were identified, raising concerns, while the phospholipid types showed no major differences among cricket species.
Article
Biology
Bingjian Ren, Pengfei Kong, Fatima Hedar, Jos F. Brouwers, Nishith Gupta
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Aike Jeucken, Miaomiao Zhou, Marc M. S. M. Wosten, Jos F. Brouwers
Summary: n-Butanol is a versatile compound that shows promise as a biofuel, with potential applications in producing complex molecules like bioplastics. This study investigated the impact of n-butanol on E. coli lipid metabolism, identifying key lipids and pathways influencing n-butanol tolerance. The research provides new insights into bacterial lipid metabolism.
Article
Biochemistry & Molecular Biology
Xue Bao, Martijn C. Koorengevel, Marian J. A. Groot Koerkamp, Amir Homavar, Amrah Weijn, Stefan Crielaard, Mike F. Renne, Joseph H. Lorent, Willie Jc Geerts, Michal A. Surma, Muriel Mari, Frank C. P. Holstege, Christian Klose, Anton I. P. M. de Kroon
Summary: Phosphatidylcholine (PC) is an essential membrane lipid component in most eukaryotes, but its necessity can be suppressed in yeast through cellular evolvability mechanisms involving chromosomal monosomy or a point mutation in the ACC1 gene. These adaptations lead to rewiring of lipid biosynthesis pathways and decreased activity of Acc1, resulting in altered acyl chain length and regulation of membrane fluidity.
Article
Biochemistry & Molecular Biology
Mike F. Renne, Xue Bao, Margriet W. J. Hokken, Adolf S. Bierhuizen, Martin Hermansson, Richard R. Sprenger, Tom A. Ewing, Xiao Ma, Ruud C. Cox, Jos F. Brouwers, Cedric H. De Smet, Christer S. Ejsing, Anton I. P. M. de Kroon
Summary: Our study reveals the importance of ERMES and Vps39p in mediating the transfer of di-unsaturated phospholipids to mitochondria. This supports the concept that lipid flow between membranes is limited by molecular species-dependent lipid efflux and concentration gradients between membranes.
Article
Biotechnology & Applied Microbiology
Delilah Hendriks, Jos F. Brouwers, Karien Hamer, Maarten H. Geurts, Lea Luciana, Simone Massalini, Carmen Lopez-Iglesias, Peter J. Peters, Maria J. Rodriguez-Colman, Susana Chuva de Sousa Lopes, Benedetta Artegiani, Hans Clevers
Summary: Organoid models of early liver disease, such as nonalcoholic fatty liver disease (NAFLD), are valuable for target discovery and drug screening. Using human fetal hepatocyte organoids, the first stage of NAFLD, steatosis, was successfully modeled with various triggers. Screening of drug candidates identified compounds that effectively resolved steatosis by repressing de novo lipogenesis. The study also introduced FatTracer, a CRISPR screening platform, to identify steatosis modulators and potential targets.
NATURE BIOTECHNOLOGY
(2023)
Article
Biology
Bingjian Ren, Xiaohan Liang, Jos F. Brouwers, Rosalba Cruz Miron, Bang Shen, Nishith Gupta
Summary: A genetic and lipidomic investigation showed that depletion of ECT in Toxoplasma gondii disrupts PtdEtn synthesis and results in parasite death. T. gondii salvages ether-PtdEtn from its host cells. This study reveals the diverse mechanisms employed by T. gondii to produce different forms of PtdEtn.
COMMUNICATIONS BIOLOGY
(2023)
Article
Nutrition & Dietetics
Hidde P. P. van Steenwijk, Evi Winter, Edward Knaven, Jos F. F. Brouwers, Myrthe van Baardwijk, Jasper B. B. van Dalum, Teus J. C. Luijendijk, Frits H. M. van Osch, Freddy J. J. Troost, Aalt Bast, Khrystyna O. O. Semen, Alie de Boer
Summary: This study investigated the effects of broccoli sprout consumption, a source of sulforaphane, on platelet functionality. The results showed that sulforaphane can improve platelet responsiveness. This study suggests the potential clinical application of sulforaphane in regulating platelet response.
FRONTIERS IN NUTRITION
(2023)