Fungal sphingolipids: role in the regulation of virulence and potential as targets for future antifungal therapies

The AGC Kinase YpkA Regulates Sphingolipids Biosynthesis and Physically Interacts With SakA MAP Kinase in Aspergillus fumigatus

(2019) João Henrique Tadini Marilhano Fabri et al.   Frontiers in Microbiology

SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents

(2019) Krupanandan Haranahalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids

(2018) Cristina Lazzarini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi

(2018) Caroline Mota Fernandes et al.   mBio

Structural absorption by barbule microstructures of super black bird of paradise feathers

(2018) Dakota E. McCoy et al.   Nature Communications

The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans

(2018) Mansa A. Munshi et al.   Cell Reports

The Multifunctional Fungal Ergosterol

(2018) Marcio L. Rodrigues   mBio

The antifungal pipeline: a reality check

(2017) John R. Perfect   NATURE REVIEWS DRUG DISCOVERY

Sphingolipids as targets for treatment of fungal infections

(2016) Rodrigo Rollin-Pinheiro et al.   Future Medicinal Chemistry

Functional characterization of theAspergillus nidulansglucosylceramide pathway reveals that LCB Δ8-desaturation and C9-methylation are relevant to filamentous growth, lipid raft localization andPsd1 defensin activity

(2016) C. M. Fernandes et al.   MOLECULAR MICROBIOLOGY

Azole antifungals: 35 years of invasive fungal infection management

(2015) David Allen et al.   Expert Review of Anti-Infective Therapy

Contribution of Clinically Derived Mutations inERG11to Azole Resistance in Candida albicans

(2014) Stephanie A. Flowers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Compositional and immunobiological analyses of extracellular vesicles released byCandida albicans

(2014) Gabriele Vargas et al.   CELLULAR MICROBIOLOGY

Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms

(2014) Anuradha Chowdhary et al.   Future Microbiology

Amphotericin forms an extramembranous and fungicidal sterol sponge

(2014) Thomas M Anderson et al.   Nature Chemical Biology

Mechanisms of Antifungal Drug Resistance

(2014) Leah E. Cowen et al.   Cold Spring Harbor Perspectives in Medicine

Synthesis and Biological Properties of Fungal Glucosylceramide

(2014) Maurizio Del Poeta et al.   PLoS Pathogens

Lipids of Candida albicans and their role in multidrug resistance

(2013) Rajendra Prasad et al.   CURRENT GENETICS

Erg11mutations associated with azole resistance in clinical isolates ofCandida albicans

(2013) Ming-Jie Xiang et al.   FEMS YEAST RESEARCH

The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin

(2013) John M. Wadsworth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NOA36 Protein Contains a Highly Conserved Nucleolar Localization Signal Capable of Directing Functional Proteins to the Nucleolus, in Mammalian Cells

(2013) Ivan S. de Melo et al.   PLoS One

The biology and chemistry of antifungal agents: A review

(2012) Muthu K Kathiravan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

(2012) Stephanie A. Flowers et al.   EUKARYOTIC CELL

A fluorescent assay for ceramide synthase activity

(2012) Hyun Joon Kim et al.   JOURNAL OF LIPID RESEARCH

Amphotericin primarily kills yeast by simply binding ergosterol

(2012) K. C. Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans

(2011) Arpita Singh et al.   CELLULAR MICROBIOLOGY

Two Pathways of Sphingolipid Biosynthesis Are Separated in the YeastPichia pastoris

(2011) Philipp Ternes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation

(2011) A. A. Lattif et al.   MICROBIOLOGY-SGM

Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans

(2011) Seon Ah Cheon et al.   MOLECULAR MICROBIOLOGY

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

(2011) M. Spitzer et al.   Molecular Systems Biology

Control of Glucosylceramide Production and Morphogenesis by the Bar1 Ceramide Synthase in Fusarium graminearum

(2011) William R. Rittenour et al.   PLoS One

Lipid signalling in pathogenic fungi

(2010) Arpita Singh et al.   CELLULAR MICROBIOLOGY

Echinocandin Antifungal Drugs in Fungal Infections

(2010) Sharon C.-A. Chen et al.   DRUGS

Extracellular Vesicles from Cryptococcus neoformans Modulate Macrophage Functions

(2010) D. L. Oliveira et al.   INFECTION AND IMMUNITY

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

(2010) Suzanne M Noble et al.   NATURE GENETICS

The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity

(2009) Andrea Kotz et al.   FUNGAL GENETICS AND BIOLOGY

Tsc10p and FVT1: topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals

(2009) Sita D. Gupta et al.   JOURNAL OF LIPID RESEARCH

Candida albicans sphingolipid C9-methyltransferase is involved in hyphal elongation

(2009) T. Oura et al.   MICROBIOLOGY-SGM

Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry

(2009) C. S. Ejsing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunocompromised Hosts: Immunopharmacology of Modern Antifungals

(2008) R. Ben‐Ami et al.   CLINICAL INFECTIOUS DISEASES

Thematic Review Series: Sphingolipids.New insights into sphingolipid metabolism and function in budding yeast

(2008) Robert C. Dickson   JOURNAL OF LIPID RESEARCH

Disruption of the sphingolipid  8-desaturase gene causes a delay in morphological changes in Candida albicans

(2008) T. Oura et al.   MICROBIOLOGY-SGM

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype

(2008) Leah E. Cowen   NATURE REVIEWS MICROBIOLOGY

Apical Sterol-rich Membranes Are Essential for Localizing Cell End Markers That Determine Growth Directionality in the Filamentous Fungus Aspergillus nidulans

(2007) Norio Takeshita et al.   MOLECULAR BIOLOGY OF THE CELL