Macrophages play a key role in tissue repair and regeneration

IL4 stimulated macrophages promote axon regeneration after peripheral nerve injury by secreting uPA to stimulate uPAR upregulated in injured axons

(2022) Yuki Matsui et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA-382 Promotes M2-Like Macrophage via the SIRP-α/STAT3 Signaling Pathway in Aristolochic Acid-Induced Renal Fibrosis

(2022) Xiaoyan Wang et al.   Frontiers in Immunology

Macrophage depletion impairs neonatal tendon regeneration

(2021) Kristen L. Howell et al.   FASEB JOURNAL

Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)

(2021) Ning Li et al.   Molecular Medicine Reports

Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

(2021) P. A. Louwe et al.   Nature Communications

Molecular Mechanisms of Fetal Tendon Regeneration Versus Adult Fibrous Repair

(2021) Iris Ribitsch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mammals fail to regenerate organs when wound contraction drives scar formation

(2021) Ioannis V. Yannas et al.   npj Regenerative Medicine

Fetal Immunomodulatory Environment Following Cartilage Injury—The Key to CARTILAGE Regeneration?

(2021) Iris Ribitsch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy

(2021) Baihai Jiao et al.   Cells

M1 macrophage infiltration exacerbate muscle/bone atrophy after peripheral nerve injury

(2020) Nobuhiro Shimada et al.   BMC MUSCULOSKELETAL DISORDERS

Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle

(2020) Francescopaolo Iavarone et al.   EMBO REPORTS

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation

(2020) Simon McArthur et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

(2020) Filipa C. Simões et al.   Nature Communications

Macrophage-Secreted Lipocalin-2 Promotes Regeneration of Injured Primary Murine Renal Tubular Epithelial Cells

(2020) Anja Urbschat et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing

(2020) Patricia M. Seraphim et al.   LIFE SCIENCES

Wnt/β-Catenin in Acute Kidney Injury and Progression to Chronic Kidney Disease

(2020) Tessa Huffstater et al.   SEMINARS IN NEPHROLOGY

Hepatic Macrophages in Liver Injury

(2020) Zhao Shan et al.   Frontiers in Immunology

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

(2020) Jing Zhang et al.   Cell Metabolism

Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis

(2020) Hanbo Li et al.   Protein & Cell

Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury

(2020) Jinghua Wu et al.   EBioMedicine

Cannabinoid type 2 receptor manipulates skeletal muscle regeneration partly by regulating macrophage M1/M2 polarization in IR injury in mice

(2020) Penghao Jiang et al.   LIFE SCIENCES

Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair

(2020) Sheikh Rayees et al.   Frontiers in Immunology

Blastemal progenitors modulate immune signaling during early limb regeneration

(2019) Stephanie L. Tsai et al.   DEVELOPMENT

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

(2019) Lixia Li et al.   Frontiers in Cellular Neuroscience

Impaired Skeletal Muscle Regeneration Induced by Macrophage Depletion Could Be Partly Ameliorated by MGF Injection

(2019) Xiaoguang Liu et al.   Frontiers in Physiology

A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves

(2019) Julia Kolter et al.   IMMUNITY

Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases

(2019) Junio Dort et al.   Stem Cells International

IL-1 Family Members in Cancer; Two Sides to Every Story

(2019) Kevin J. Baker et al.   Frontiers in Immunology

Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater

(2019) Andreas Weigert et al.   Frontiers in Immunology

Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish

(2019) Laura Bevan et al.   CARDIOVASCULAR RESEARCH

CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization

(2019) Meng Li et al.   Cellular & Molecular Immunology

Prostaglandin D2 synthase modulates macrophage activity and accumulation in injured peripheral nerves

(2019) Maria Grazia Forese et al.   GLIA

The BACH1–HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration

(2019) Andreas Patsalos et al.   JOURNAL OF IMMUNOLOGY

Non-invasive Imaging and Modeling of Liver Regeneration After Partial Hepatectomy

(2019) Sara Zafarnia et al.   Frontiers in Physiology

Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration

(2019) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early Development of Resident Macrophages in the Mouse Cochlea Depends on Yolk Sac Hematopoiesis

(2019) Ippei Kishimoto et al.   Frontiers in Neurology

Macrophages in Zebrafish Models of Liver Diseases

(2019) Arkadi Shwartz et al.   Frontiers in Immunology

Contribution of resident and recruited macrophages in vascular physiology and pathology

(2018) Li Zhang   CURRENT OPINION IN HEMATOLOGY

The blastema and epimorphic regeneration in mammals

(2018) Ashley W. Seifert et al.   DEVELOPMENTAL BIOLOGY

Beneficial or Harmful Role of Macrophages in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis

(2018) Donghui Shen et al.   MEDIATORS OF INFLAMMATION

Interleukin-6: designing specific therapeutics for a complex cytokine

(2018) Christoph Garbers et al.   NATURE REVIEWS DRUG DISCOVERY

Correction to: TNF signaling and macrophages govern fin regeneration in zebrafish larvae

(2018) Mai Nguyen-Chi et al.   Cell Death & Disease

Mesenchymal stem cells and extracellular matrix scaffold promote muscle regeneration by synergistically regulating macrophage polarization toward the M2 phenotype

(2018) Xinyu Qiu et al.   Stem Cell Research & Therapy

Macrophages in inflammation, repair and regeneration

(2018) Yumiko Oishi et al.   INTERNATIONAL IMMUNOLOGY

Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease

(2018) Cinzia Rota et al.   Stem Cell Research & Therapy

Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages

(2018) Junhua Xi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

M2b macrophage polarization and its roles in diseases

(2018) Le-xun Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

(2018) Tomohito Izumi et al.   Nature Communications

Sustained release of collagen VI potentiates sciatic nerve regeneration by modulating macrophage phenotype

(2017) Dan Lv et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Langerhans Cells – The Macrophage in Dendritic Cell Clothing

(2017) Thomas Doebel et al.   TRENDS IN IMMUNOLOGY

Macrophage-released ADAMTS1 promotes muscle stem cell activation

(2017) Hongqing Du et al.   Nature Communications

Ly6Chi Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury

(2017) Nadine Graubardt et al.   Frontiers in Immunology

Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration

(2017) Yuko Ishida et al.   Scientific Reports

Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration

(2016) Virpi Talman et al.   CELL AND TISSUE RESEARCH

IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells

(2016) Jiajia Xu et al.   CELL DEATH AND DIFFERENTIATION

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Macrophage Depletion Impairs Skeletal Muscle Regeneration: the Roles of Pro-fibrotic Factors, Inflammation, and Oxidative Stress

(2016) Weihua Xiao et al.   INFLAMMATION

Wound healing and treating wounds

(2016) Laurel M. Morton et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Hypertrophic scarring: the greatest unmet challenge after burn injury

(2016) Celeste C Finnerty et al.   LANCET

Macrophage-derived Lipocalin-2 contributes to ischemic resistance mechanisms by protecting from renal injury

(2016) Michaela Jung et al.   Scientific Reports

Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury

(2015) Peiwen Chen et al.   ACTA NEUROPATHOLOGICA

Interleukin-6: Biology, signaling and strategies of blockade

(2015) Fred Schaper et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

(2015) J. Knuever et al.   JOURNAL OF IMMUNOLOGY

CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype

(2015) Hugo Peluffo et al.   Journal of Neuroinflammation

Role of IL-10 in Resolution of Inflammation and Functional Recovery after Peripheral Nerve Injury

(2015) B. Siqueira Mietto et al.   JOURNAL OF NEUROSCIENCE

Reversibility of liver fibrosis

(2015) Mengxi Sun et al.   Clinics and Research in Hepatology and Gastroenterology

Recurrent turnover of senescent cells during regeneration of a complex structure

(2015) Maximina H Yun et al.   eLife

IL-12-and IL-23 in health and disease

(2014) Andrew L. Croxford et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases

(2014) Remo C Russo et al.   Expert Review of Clinical Immunology

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Cytokines in Common Variable Immunodeficiency as Signs of Immune Dysregulation and Potential Therapeutic Targets – A Review of the Current Knowledge

(2014) Farnaz Najmi Varzaneh et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Macrophages are required for neonatal heart regeneration

(2014) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury

(2014) S. C. Huen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Macrophage-mediated injury and repair after ischemic kidney injury

(2014) Sarah C. Huen et al.   PEDIATRIC NEPHROLOGY

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response

(2013) S. de Oliveira et al.   JOURNAL OF IMMUNOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans

(2012) Charalambos Gustav Antoniades et al.   HEPATOLOGY

Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation

(2012) Kristin Seré et al.   IMMUNITY

Interleukin-6/Signal Transducer and Activator of Transcription 3 (STAT3) Pathway Is Essential for Macrophage Infiltration and Myoblast Proliferation during Muscle Regeneration

(2012) Congcong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-17 and TNF-  Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation

(2012) G. K. Griffin et al.   JOURNAL OF IMMUNOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat

(2012) Shuai Xiang et al.   PLoS One

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

(2011) Antonella Pellicoro et al.   HEPATOLOGY

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

A crucial role for TNF-α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5

(2009) SM Vieira et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interleukin-10: new perspectives on an old cytokine

(2009) David M. Mosser et al.   IMMUNOLOGICAL REVIEWS

The Role of Macrophage-Derived IL-1 in Induction and Maintenance of Angiogenesis

(2009) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY