Article
Immunology
Manuel Flores Molina, Mohamed N. Abdelnabi, Sabrina Mazouz, Deborah Villafranca-Baughman, Vincent Quoc-Huy Trinh, Shafi Muhammad, Nathalie Bedard, David Osorio Laverde, Ghada S. Hassan, Adriana Di Polo, Naglaa H. Shoukry
Summary: This study characterizes the intrahepatic macrophage populations and their roles during acute liver injury using multiple techniques. The results reveal distinct spatial and temporal distribution of Kupffer cells (KCs) and monocyte-derived macrophages (MoMFs) and provide insights into their complementary roles during necroinflammation and repair phases. These findings contribute to our understanding of macrophage function and wound healing in acute liver injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Dechun Feng, Xiaogang Xiang, Yukun Guan, Adrien Guillot, Hongkun Lu, Chingwen Chang, Yong He, Hua Wang, Hongna Pan, Cynthia Ju, Sean P. Colgan, Frank Tacke, Xin Wei Wang, George Kunos, Bin Gao
Summary: Monocyte-derived macrophages (MoMFs) are rapidly recruited to and encapsulated necrotic areas during liver injury, playing a key role in repairing necrotic lesions. They induce cell death-resistant hepatocytes to form a protective capsule and participate in necrotic tissue removal and liver repair. MoMFs also activate hepatic stellate cells to eliminate necrotic lesions through α-smooth muscle actin expression.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Immunology
Weiyang Li, Na Chang, Liying Li
Summary: Kupffer cells are key regulators of liver immunity, maintaining homeostasis and playing central roles in acute and chronic liver injury. Understanding their heterogeneity and functions may provide opportunities for liver injury therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Weiyang Li, Yuanru Yang, Lin Yang, Na Chang, Liying Li
Summary: This study reveals that bone marrow monocyte-derived Kupffer cells (MoKCs) dominate in injured livers. MoKCs exhibit enhanced proliferative and anti-apoptotic properties compared to embryonic KCs (EmKCs), promoting repair and attenuating fibrosis while reducing functional damage, necrosis, and fibrosis.
Article
Cell Biology
Akanksha Sharma, Ramesh Kudira, Jiang Wang, Alexander Miethke, Chandrashekhar R. Gandhi
Summary: Depletion of hepatic stellate cells (HSCs) in mice confers resistance to liver injury and inflammation caused by CCl4 rechallenge, showing increased hepatocyte necrosis, more macrophages, and higher levels of inflammatory cytokine expression. Moreover, HSC-sufficient mice experience rapid fibrogenesis and activation of HSCs, indicating that even transiently activated HSCs can contribute to reactivation and fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Immunology
Bin Li, Xinwei Qi, Yumei Liu, Yi Yan, Jiaoyu Shan, Xuanlin Cai, Jie Lv, Xuan Zhou, Tao Yu, Xiumin Ma
Summary: This study investigated the dynamic changes of monocytes, macrophages, and related cytokines in animal models of persistent infection of E. multilocularis. The results showed significant liver lesions in the later stages of infection, decreased proportion of Ly6C(hi) monocytes in the peripheral blood, and fluctuating levels of Ly6C(1o) monocytes. The expression of CX3CL1, CX3CR1, CD11b, CD163, and iNOS in the liver increased, along with increased levels of TNF-alpha and Argl mRNA. Furthermore, the levels of IFN-gamma, IL-17, IL-4, and IL-10 in peripheral blood increased with the duration of infection.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Review
Medicine, General & Internal
Ines Coelho, Nadia Duarte, Maria Paula Macedo, Carlos Penha-Goncalves
Summary: Liver disease is a major cause of global mortality, characterized by tissue damage, inflammation, and scar formation. Liver cell populations play a crucial role in maintaining tissue homeostasis, while inflammation is a key factor in liver pathology.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Mandy M. Chan, Sabine Daemen, Joseph W. Beals, Marina Terekhova, Bin Q. Yang, Christina F. Fu, Li He, Arick C. Park, Gordon I. Smith, Babak Razani, Kathleen Byrnes, Wandy L. Beatty, Shaina R. Eckhouse, J. Christopher Eagon, Daniel Ferguson, Brian N. Finck, Samuel Klein, Maxim N. Artyomov, Joel D. Schilling
Summary: This study revealed the presence of macrophage subsets in the human liver with MAFLD that closely resemble those found in mouse models of fatty liver disease, showing a correlation between recruited myeloid cells and the degree of liver steatosis. MdMs were shown to be involved in lipid uptake during the early stages of MALFD.
Article
Biochemistry & Molecular Biology
Andrey Elchaninov, Anastasia Lokhonina, Polina Vishnyakova, Anna Soboleva, Anastasiya Poltavets, Daria Artemova, Andrey Makarov, Valeria Glinkina, Dmitry Goldshtein, Galina Bolshakova, Gennady Sukhikh, Timur Fatkhudinov
Summary: The study showed that the number of MARCO-positive macrophages in the regenerating liver increased on the first and third day after resection, indicating activation of MARCO synthesis in liver macrophages. Stimulation with LPS led to an increase in the expression of the Marco gene in both Kupffer cells and macrophages of bone marrow origin.
Review
Immunology
Amelia Kulle, Ajitha Thanabalasuriar, Taylor S. Cohen, Marta Szydlowska
Summary: Resident macrophages play a crucial role in tissue maintenance by defending against pathogens and regulating inflammatory tone and tissue structure. This review focuses on the developmental origin of liver and lung resident macrophages, their contribution to host defense, and the mechanisms they use to regulate tissue homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Arjuna Singanayagam, Evangelos Triantafyllou
Summary: Chronic liver injury can lead to immune-driven progressive fibrosis and cirrhosis, with a high risk of bacterial infections and systemic inflammation, ultimately impacting morbidity and mortality. Macrophages in different tissues play a crucial role in the development and progression of inflammation and fibrosis in chronic liver failure, suggesting potential for macrophage modulation as a therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Siyer Roohani, Frank Tacke
Summary: The liver plays a crucial role in the immune system by interacting with antigens and microbial products, with Kupffer cells being key phagocytes. Liver injury results in an expansion of hepatic macrophages, which can lead to various outcomes from recovery to chronic inflammation, fibrosis, cirrhosis, and even cancer. Understanding the classification and function of hepatic macrophages is essential in studying healthy and injured livers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Daniel J. Hellenbrand, Charles M. Quinn, Zachariah J. Piper, Carolyn N. Morehouse, Jordyn A. Fixel, Amgad S. Hanna
Summary: Traumatic spinal cord injury leads to a loss of motor and sensory function, and triggers a cascade of secondary injury responses. The inflammatory response is complex, involving a variety of cells and signaling molecules. Understanding the pathophysiology of SCI is crucial for identifying therapeutic targets to attenuate secondary damage.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Engineering, Biomedical
Ruben F. Pereira, Bianca N. Lourenco, Paulo J. Bartolo, Pedro L. Granja
Summary: A multifunctional bioink was designed in this study to control cell fate through independent manipulation of biochemical and biophysical cues in extrusion bioprinting. The rheology of the bioink was controlled by manipulating ionic gelation, while the mechanical and biochemical properties of hydrogels were tailored through post-printing thiol-ene reaction. The bioink can be used for building functional cell- and tissue-specific constructs with controlled cellular behavior.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Cell Biology
Xuejiao Chen, Ziyi Wang, Sheng Han, Zeng Wang, Yu Zhang, Xiangdong Li, Nan Xia, Wenjie Yu, Chenyang Jia, Yong Ni, Liyong Pu
Summary: Liver fibrosis is a danger signal for liver cancer, but there is no effective clinical means to regulate its progress. It has been found that inhibiting SYK in monocyte-derived macrophages may help alleviate chronic liver fibrosis.
CELL DEATH & DISEASE
(2021)