The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases

IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis

(2014) L. Skov et al.   JOURNAL OF IMMUNOLOGY

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation

(2014) A. Gaggar et al.   JOURNAL OF IMMUNOLOGY

CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth

(2014) Aihua Li et al.   Translational Oncology

Selective Blockade of Tumor Necrosis Factor Receptor I Inhibits Proinflammatory Cytokine and Chemokine Production in Human Rheumatoid Arthritis Synovial Membrane Cell Cultures

(2013) Emily M. Schmidt et al.   ARTHRITIS AND RHEUMATISM

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

(2013) Hiroshi Katoh et al.   CANCER CELL

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Innate Immune Functions of Immature Neutrophils in Patients With Sepsis and Severe Systemic Inflammatory Response Syndrome*

(2013) Geneviève Drifte et al.   CRITICAL CARE MEDICINE

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

(2013) Oliver Soehnlein et al.   EMBO Molecular Medicine

Cytokines secreted by macrophages isolated from tumor microenvironment of inflammatory breast cancer patients possess chemotactic properties

(2013) Mona M. Mohamed et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Differential Roles of CXCL2 and CXCL3 and Their Receptors in Regulating Normal and Asthmatic Airway Smooth Muscle Cell Migration

(2013) L. A. Al-Alwan et al.   JOURNAL OF IMMUNOLOGY

CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model

(2013) Anne-Gaëlle Besnard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin 8 and the male genital tract

(2013) Francesco Lotti et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Chemokine contribution to neuropathic pain: Respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons

(2013) Zhi-Jun Zhang et al.   PAIN

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme Oxygenase Inhibition Enhances Neutrophil Migration Into the Bronchoalveolar Spaces and Improves the Outcome of Murine Pneumonia-Induced Sepsis

(2013) Paula Giselle Czaikoski et al.   SHOCK

Pathology of asthma

(2013) Makoto Kudo et al.   Frontiers in Microbiology

Role of Chemokines in the Pathogenesis of Acute Lung Injury

(2012) Madhav Bhatia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of Nicotinamide Phosphoribosyltransferase Reduces Neutrophil-Mediated Injury in Myocardial Infarction

(2012) Fabrizio Montecucco et al.   ANTIOXIDANTS & REDOX SIGNALING

State of progress in treating cystic fibrosis respiratory disease

(2012) Patrick A Flume et al.   BMC Medicine

Structure-based design of decoy chemokines as a way to explore the pharmacological potential of glycosaminoglycans

(2012) Tiziana Adage et al.   BRITISH JOURNAL OF PHARMACOLOGY

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-Dependent and -Independent Mechanisms

(2012) J. K. Singh et al.   CLINICAL CANCER RESEARCH

Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis

(2012) Samuel Asfaha et al.   GASTROENTEROLOGY

Roles of hepatocyte and myeloid CXC chemokine receptor-2 in liver recovery and regeneration after ischemia/reperfusion in mice

(2012) Heather L. Van Sweringen et al.   HEPATOLOGY

CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway

(2012) M.-Q. Li et al.   HUMAN REPRODUCTION

Recombinant human CXCL8(3-72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of interleukin-8 receptor

(2012) YuanHua Qin et al.   IUBMB LIFE

Pathogenesis of chronic obstructive pulmonary disease

(2012) Rubin M. Tuder et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

(2012) Thomas Jamieson et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR1/2 inhibition enhances pancreatic islet survival after transplantation

(2012) Antonio Citro et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

(2012) Richard B. Moss et al.   Journal of Cystic Fibrosis

MicroRNA-31 Is Overexpressed in Psoriasis and Modulates Inflammatory Cytokine and Chemokine Production in Keratinocytes via Targeting Serine/Threonine Kinase 40

(2012) N. Xu et al.   JOURNAL OF IMMUNOLOGY

CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis

(2012) Monica Roy et al.   Journal of Neuroinflammation

Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6

(2012) Francisco Carmona et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

CXCR2 in Acute Lung Injury

(2012) F. M. Konrad et al.   MEDIATORS OF INFLAMMATION

GEF-H1-RhoA signaling pathway mediates LPS-induced NF-κB transactivation and IL-8 synthesis in endothelial cells

(2012) Feng Guo et al.   MOLECULAR IMMUNOLOGY

Statins Affect the Presentation of Endothelial Chemokines by Targeting to Multivesicular Bodies

(2012) Johanna Hol et al.   PLoS One

Crucial Involvement of Tumor-Associated Neutrophils in the Regulation of Chronic Colitis-Associated Carcinogenesis in Mice

(2012) Kun Shang et al.   PLoS One

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The chemokine receptor CXCR2 and coronavirus-induced neurologic disease

(2012) Jason G. Weinger et al.   VIROLOGY

IL-8 as a urinary biomarker for the detection of bladder cancer

(2012) Virginia Urquidi et al.   BMC Urology

Chemokine Receptor CXCR2 Mediates Bacterial Clearance Rather Than Neutrophil Recruitment in a Murine Model of Pneumonic Plague

(2011) Nicholas A. Eisele et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional heterogeneity of human effector CD8+ T cells

(2011) H. Takata et al.   BLOOD

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

(2011) Aili L. Lazaar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor

(2011) R Bertini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis

(2011) Feng Wang et al.   CARDIOVASCULAR RESEARCH

The Association Between a Darc Gene Polymorphism and Clinical Outcomes in African American Patients With Acute Lung Injury

(2011) Kirsten Neudoerffer Kangelaris et al.   CHEST

Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor

(2011) R. Virtala et al.   CLINICAL AND EXPERIMENTAL ALLERGY

IL-33 induces skin inflammation with mast cell and neutrophil activation

(2011) Axel J. Hueber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCR1andCXCR2haplotypes synergistically modulate cystic fibrosis lung disease

(2011) Michael S.D. Kormann et al.   EUROPEAN RESPIRATORY JOURNAL

CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis

(2011) Emanuele Tirotta et al.   GLIA

Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome

(2011) Cailin E. Joyce et al.   HUMAN MOLECULAR GENETICS

The Multitasking Organ: Recent Insights into Skin Immune Function

(2011) Paola Di Meglio et al.   IMMUNITY

Adipose Tissue, Inflammation and Atherosclerosis

(2011) Birgit Gustafson   Journal of Atherosclerosis and Thrombosis

Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis

(2011) Yijun Carrier et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

STAT3 Genotypic Variation and Cellular STAT3 Activation and Colon Leukocyte Recruitment in Pediatric Crohn Disease

(2011) Tara A. Willson et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8

(2011) Łukasz Milewski et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Retraction Note to: Retraction: CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

(2011) Veronica Marcos et al.   NATURE MEDICINE

Interleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoch–Schönlein purpura

(2011) Yilmaz Tabel et al.   RHEUMATOLOGY INTERNATIONAL

(Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis

(2011) Debby den Uyl et al.   ARTHRITIS RESEARCH & THERAPY

Chemokine homeostasis vs. chemokine presentation during severe acute lung injury: the other side of the Duffy antigen receptor for chemokines

(2010) Alexander Zarbock et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Phosphoinositide-3 Kinase γ Activity Contributes to Sepsis and Organ Damage by Altering Neutrophil Recruitment

(2010) Erica L. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Essential Role of CCR2 in Neutrophil Tissue Infiltration and Multiple Organ Dysfunction in Sepsis

(2010) Fabricio O. Souto et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tissue Factor–Factor VIIa complex induces cytokine expression in coronary artery smooth muscle cells

(2010) G. Demetz et al.   ATHEROSCLEROSIS

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: A crucial role for Krüppel-like factor 2

(2010) L.J.H. van Tits et al.   ATHEROSCLEROSIS

STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction

(2010) H. Nguyen-Jackson et al.   BLOOD

Cooperative role of tumour necrosis factor-α, interleukin-1β and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice

(2010) Daniela Sachs et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis

(2010) Liyan Wang et al.   CLINICAL IMMUNOLOGY

The interaction of coagulation factor XII and monocyte/macrophages mediating peritoneal metastasis of epithelial ovarian cancer

(2010) Ruili Wang et al.   GYNECOLOGIC ONCOLOGY

CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury

(2010) Callisia Clarke et al.   HEPATOLOGY

CXCL5 Regulates Chemokine Scavenging and Pulmonary Host Defense to Bacterial Infection

(2010) Junjie Mei et al.   IMMUNITY

Importance of CXC Chemokine Receptor 2 in Alveolar Neutrophil and Exudate Macrophage Recruitment in Response to Pneumococcal Lung Infection

(2010) W. Herbold et al.   INFECTION AND IMMUNITY

Angiogenesis drives psoriasis pathogenesis

(2010) Regina Heidenreich et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The Cytomegalovirus UL146 Gene Product vCXCL1 Targets Both CXCR1 and CXCR2 as an Agonist

(2010) Hans R. Lüttichau   JOURNAL OF BIOLOGICAL CHEMISTRY

Microparticles stimulate angiogenesis by inducing ELR+ CXC-chemokines in synovial fibroblasts

(2010) Nicole Reich et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IL-1 family nomenclature

(2010) Charles Dinarello et al.   NATURE IMMUNOLOGY

CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

(2010) Veronica Marcos et al.   NATURE MEDICINE

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

(2010) Jose C Alves-Filho et al.   NATURE MEDICINE

Putting a dampener on inflammation

(2010) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

New Insights in the Immunologic Basis of Psoriasis

(2010) Kristine E. Nograles et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Association of Polymorphisms of Interleukin-8, CXCR1, CXCR2, and Selectin With Allograft Outcomes in Kidney Transplantation

(2010) Han Ro et al.   TRANSPLANTATION

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects

(2009) O. Holz et al.   EUROPEAN RESPIRATORY JOURNAL

Hepatocyte Transplantation-Induced Liver Inflammation Is Driven by Cytokines-Chemokines Associated With Neutrophils and Kupffer Cells

(2009) Natan Krohn et al.   GASTROENTEROLOGY

Monitoring of endothelial cell activation in experimental sepsis with a two-step cell culture model

(2009) Anita Schildberger et al.   Innate Immunity

Human Benign Prostatic Hyperplasia Stromal Cells As Inducers and Targets of Chronic Immuno-Mediated Inflammation

(2009) G. Penna et al.   JOURNAL OF IMMUNOLOGY

CXCR2 Is Required for Neutrophilic Airway Inflammation and Hyperresponsiveness in a Mouse Model of Human Rhinovirus Infection

(2009) D. R. Nagarkar et al.   JOURNAL OF IMMUNOLOGY

CXCR2-Dependent Mucosal Neutrophil Influx Protects against Colitis-Associated Diarrhea Caused by an Attaching/Effacing Lesion-Forming Bacterial Pathogen

(2009) M. E. Spehlmann et al.   JOURNAL OF IMMUNOLOGY

The functional significance behind expressing two IL-8 receptor types on PMN

(2009) RoseMarie Stillie et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Therapeutic Effect of Blocking CXCR2 on Neutrophil Recruitment and Dextran Sodium Sulfate-Induced Colitis

(2009) S. M. Farooq et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Rheumatoid arthritis

(2009) Lars Klareskog et al.   LANCET

A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage

(2009) Jens Bedke et al.   MOLECULAR IMMUNOLOGY

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Serum and Urine Interleukin-8 on Acute Pyelonephritis and Subsequent Renal Scarring in Children

(2009) Ji-Nan Sheu et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

(2009) J. C. Alves-Filho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of Interleukin-8 in Expressed Prostatic Secretion as a Reliable Biomarker of Inflammation in Benign Prostatic Hyperplasia

(2009) Liangren Liu et al.   UROLOGY

Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL1

(2008) Kakuri M. Omari et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of the Chemokine Receptor CXCR2 in Bleomycin-Induced Pulmonary Inflammation and Fibrosis

(2008) Remo C. Russo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Potential Role of the CXC Chemokine GROα in Atherosclerosis and Plaque Destabilization

(2008) Unni M. Breland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chemokines in Atherosclerosis

(2008) Alma Zernecke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature

(2008) Fernanda M. Coelho et al.   ARTHRITIS AND RHEUMATISM

CXCR2‐specific chemokines mediate leukotriene B4–dependent recruitment of neutrophils to inflamed joints in mice with antigen‐induced arthritis

(2008) Renata Grespan et al.   ARTHRITIS AND RHEUMATISM

Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice

(2008) A Zarbock et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice

(2008) Satoshi Kuboki et al.   HEPATOLOGY

The Th17–ELR+CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

(2008) Thaddeus Carlson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional Characterization of IL-17F as a Selective Neutrophil Attractant in Psoriasis

(2008) Hideaki Watanabe et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice

(2008) Allisson Freire Bento et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chemokine-like functions of MIF in atherosclerosis

(2008) Andreas Schober et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

How chemokines invite leukocytes to dance

(2008) Marcus Thelen et al.   NATURE IMMUNOLOGY

Immune Mediators in Idiopathic Nephrotic Syndrome: Evidence for a Relation Between Interleukin 8 and Proteinuria

(2008) Marcelo F O Souto et al.   PEDIATRIC RESEARCH

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

(2008) C. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE ROLE OF NEUTROPHILS IN SEVERE SEPSIS

(2008) José C. Alves-Filho et al.   SHOCK

Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study

(2008) Kristin Andreas et al.   ARTHRITIS RESEARCH & THERAPY

Murine models of pulmonary fibrosis

(2007) Bethany B. Moore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY