Human immunodeficiency virus-1 core: The Trojan horse in virus–host interaction

TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection

(2022) Anastasia Selyutina et al.   Viruses-Basel

Emerging Roles of Cyclophilin A in Regulating Viral Cloaking

(2022) John E. Mamatis et al.   Frontiers in Microbiology

Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA

(2022) Sunnie M. Yoh et al.   MOLECULAR CELL

HIV Capsid and Integration Targeting

(2021) Alan N. Engelman   Viruses-Basel

From Capsids to Complexes: Expanding the Role of TRIM5α in the Restriction of Divergent RNA Viruses and Elements

(2021) Kevin M. Rose et al.   Viruses-Basel

Structure, Function, and Interactions of the HIV-1 Capsid Protein

(2021) Eric Rossi et al.   Life-Basel

Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection

(2021) Qingtang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation

(2021) Gilberto Betancor et al.   Nature Microbiology

HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules

(2021) Akatsuki Saito et al.   Retrovirology

Nuclear Import of HIV-1

(2021) Qi Shen et al.   Viruses-Basel

Toll-Like Receptor (TLR) Signaling Enables Cyclic GMP-AMP Synthase (cGAS) Sensing of HIV-1 Infection in Macrophages

(2021) Mohammad Adnan Siddiqui et al.   mBio

GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors

(2021) Anastasia Selyutina et al.   iScience

The 4th and 112th Residues of Viral Capsid Cooperatively Modulate Capsid-CPSF6 Interactions of HIV-1

(2020) Akatsuki Saito et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Sensing of HIV-1 by TLR8 activates human T cells and reverses latency

(2020) Hany Zekaria Meås et al.   Nature Communications

Sensor Sensibility—HIV-1 and the Innate Immune Response

(2020) Xin Yin et al.   Cells

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins

(2020) Annalaura Brai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Clinical targeting of HIV capsid protein with a long-acting small molecule

(2020) John O. Link et al.   NATURE

Absence of cGAS-mediated type I IFN responses in HIV-1–infected T cells

(2020) Carina Elsner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupting HIV ‐1 capsid formation causes cGAS sensing of viral DNA

(2020) Rebecca P Sumner et al.   EMBO JOURNAL

Cell type-dependent escape of capsid inhibitors by simian immunodeficiency virus SIVcpz

(2020) Augustin Penda Twizerimana et al.   JOURNAL OF VIROLOGY

Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro

(2020) Devin E. Christensen et al.   SCIENCE

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5

(2020) Steven W. Jin et al.   PLoS Pathogens

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α

(2020) Bhaskar Saha et al.   PLoS Pathogens

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

(2020) Hataf Khan et al.   eLife

FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

(2019) Mathieu Ringeard et al.   NATURE

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex

(2019) David Alejandro Bejarano et al.   eLife

HIV-1 Is a Poor Inducer of Innate Immune Responses

(2019) Oya Cingöz et al.   mBio

HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells

(2019) Junpeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

(2019) Simon Langer et al.   eLife

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

(2019) Mariia Novikova et al.   VIROLOGICA SINICA

A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing

(2019) Mohammad Adnan Siddiqui et al.   JOURNAL OF VIROLOGY

Restriction of HIV-1 and other retroviruses by TRIM5

(2019) Barbie K. Ganser-Pornillos et al.   NATURE REVIEWS MICROBIOLOGY

Vpr Enhances HIV-1 Env Processing and Virion Infectivity in Macrophages by Modulating TET2-Dependent IFITM3 Expression

(2019) Qi Wang et al.   mBio

The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction

(2019) Gilberto Betancor et al.   Cell Reports

HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS–STING-mediated NF-κB signalling

(2019) Jiaming Su et al.   Nature Microbiology

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

(2019) Kyusik Kim et al.   Nature Microbiology

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

(2018) Ashwanth C. Francis et al.   Cell Host & Microbe

HIV-1 activation of innate immunity depends strongly on the intracellular level of TREX1 and sensing of incomplete reverse transcription products

(2018) Swati Kumar et al.   JOURNAL OF VIROLOGY

Inhibitors of the HIV-1 capsid, a target of opportunity

(2018) Stephanie K. Carnes et al.   Current Opinion in HIV and AIDS

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

(2018) Xavier Lahaye et al.   CELL

HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction

(2018) Hisashi Akiyama et al.   Nature Communications

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

(2018) Melissa Kane et al.   eLife

Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

(2018) Sean Matthew McCauley et al.   Nature Communications

Role of cytokine agonists and immune checkpoint inhibitors toward HIV remission

(2018) Timothy N. Hoang et al.   Current Opinion in HIV and AIDS

Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection

(2017) Adarsh Dharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1

(2017) Shringar Rao et al.   RNA

Capsid-Dependent Host Factors in HIV-1 Infection

(2017) Masahiro Yamashita et al.   TRENDS IN MICROBIOLOGY

The structure and flexibility of conical HIV-1 capsids determined within intact virions

(2016) Simone Mattei et al.   SCIENCE

HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex

(2016) Alessandro Cinti et al.   mBio

Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

(2016) Yen-Li Li et al.   eLife

Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations

(2016) Wei Wei et al.   EBioMedicine

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1

(2015) Sunnie M. Yoh et al.   CELL

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

Innate immunity against HIV-1 infection

(2015) Marcus Altfeld et al.   NATURE IMMUNOLOGY

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

(2015) Anna-Maria Herzner et al.   NATURE IMMUNOLOGY

X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

(2015) A. T. Gres et al.   SCIENCE

Structural Insight into HIV-1 Restriction by MxB

(2014) Jennifer L. Fribourgh et al.   Cell Host & Microbe

Interferon γ-inducible Protein (IFI) 16 Transcriptionally Regulates Type I Interferons and Other Interferon-stimulated Genes and Controls the Interferon Response to both DNA and RNA Viruses

(2014) Mikayla R. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cell-Lymphocyte Cross Talk Downregulates Host Restriction Factor SAMHD1 and Stimulates HIV-1 Replication in Dendritic Cells

(2014) B. Su et al.   JOURNAL OF VIROLOGY

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

(2014) Akash Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of HIV-1 capsid in viral replication and immune evasion

(2014) Valerie Le Sage et al.   VIRUS RESEARCH

eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection

(2014) Fernando Valiente-Echeverría et al.   Nature Communications

Immunity to HIV in Early Life

(2014) Maximilian Muenchhoff et al.   Frontiers in Immunology

HIV-1 Induces the Formation of Stable Microtubules to Enhance Early Infection

(2013) Yosef Sabo et al.   Cell Host & Microbe

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest

(2012) Wei Wei et al.   CELLULAR MICROBIOLOGY

The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus

(2012) H. Hofmann et al.   JOURNAL OF VIROLOGY

Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects

(2012) Ruifeng Yang et al.   Retrovirology

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells

(2010) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS

(2009) Judd F Hultquist et al.   Future Virology

HIV-1 Accessory Protein Vpu Internalizes Cell-surface BST-2/Tetherin through Transmembrane Interactions Leading to Lysosomes

(2009) Yukie Iwabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a  TrCP-Dependent Mechanism

(2009) J. L. Douglas et al.   JOURNAL OF VIROLOGY

Target Cell Type-Dependent Modulation of Human Immunodeficiency Virus Type 1 Capsid Disassembly by Cyclophilin A

(2009) Y. Li et al.   JOURNAL OF VIROLOGY

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE