Vpr Enhances HIV-1 Env Processing and Virion Infectivity in Macrophages by Modulating TET2-Dependent IFITM3 Expression

HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion

(2019) Saina Beitari et al.   Viruses-Basel

Glycosyl-Phosphatidylinositol-Anchored Anti-HIV Env Single-Chain Variable Fragments Interfere with HIV-1 Env Processing and Viral Infectivity

(2018) Anisha Misra et al.   JOURNAL OF VIROLOGY

Vpr Targets TET2 for Degradation by CRL4 VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication

(2018) Lei Lv et al.   MOLECULAR CELL

SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans

(2017) E Kaitlynn Allen et al.   NATURE MEDICINE

Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs

(2017) Kevin Tartour et al.   PLoS Pathogens

Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction

(2016) Toshana L. Foster et al.   Cell Host & Microbe

Macrophages and HIV-1: An Unhealthy Constellation

(2016) Quentin J. Sattentau et al.   Cell Host & Microbe

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

(2016) Christian Krapp et al.   Cell Host & Microbe

Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice

(2016) Chaobaihui Ye et al.   JOURNAL OF VIROLOGY

HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest

(2015) Bizhan Romani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress Leukemia Cell Proliferation

(2015) Yiping Wang et al.   MOLECULAR CELL

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx

(2015) Patrick A. Cassiday et al.   VIROLOGY

IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein

(2015) Jingyou Yu et al.   Cell Reports

Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes

(2015) David R. Collins et al.   PLoS Pathogens

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

(2014) Nadine Laguette et al.   CELL

Vpr Overcomes Macrophage-Specific Restriction of HIV-1 Env Expression and Virion Production

(2014) Michael Mashiba et al.   Cell Host & Microbe

The role of matrix in HIV-1 envelope glycoprotein incorporation

(2014) Philip R. Tedbury et al.   TRENDS IN MICROBIOLOGY

90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1

(2013) Veronika Lodermeyer et al.   Retrovirology

HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4+ T Cells In Vivo

(2013) Kei Sato et al.   PLoS Pathogens

Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein

(2012) S Bobadilla et al.   GENE THERAPY

Lentivirus Vpr and Vpx accessory proteins usurp the cullin4–DDB1 (DCAF1) E3 ubiquitin ligase

(2012) Bizhan Romani et al.   Current Opinion in Virology

Latent HIV-1 Infection of Resting CD4+ T Cells in the Humanized Rag2-/-  c-/- Mouse

(2011) S. K. Choudhary et al.   JOURNAL OF VIROLOGY

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Rab7A Is Required for Efficient Production of Infectious HIV-1

(2011) Marina Caillet et al.   PLoS Pathogens

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

HIV-1 Vpr Loads Uracil DNA Glycosylase-2 onto DCAF1, a Substrate Recognition Subunit of a Cullin 4A-RING E3 Ubiquitin Ligase for Proteasome-dependent Degradation

(2010) Jinwoo Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Viral Protein R (VPR) and its Interactions with Host Cell

(2009) Ge Li et al.   CURRENT HIV RESEARCH

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Human Immunodeficiency Virus Type 1 Vpr-Binding Protein VprBP, a WD40 Protein Associated with the DDB1-CUL4 E3 Ubiquitin Ligase, Is Essential for DNA Replication and Embryonic Development

(2008) C. M. McCall et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS