HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137

(2020) Fengwen Zhang et al.   eLife

Disrupting HIV ‐1 capsid formation causes cGAS sensing of viral DNA

(2020) Rebecca P Sumner et al.   EMBO JOURNAL

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex

(2019) David Alejandro Bejarano et al.   eLife

Immunoproteasome activation enables human TRIM5α restriction of HIV-1

(2019) Jose M. Jimenez-Guardeño et al.   Nature Microbiology

HIV-1 Is a Poor Inducer of Innate Immune Responses

(2019) Oya Cingöz et al.   mBio

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Vaccinia virus BBK E3 ligase adaptor A55 targets importin-dependent NF-κB activation and inhibits CD8+ T-cell memory

(2019) Mitchell A. Pallett et al.   JOURNAL OF VIROLOGY

HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells

(2019) Junpeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection

(2019) Edward J.D. Greenwood et al.   Cell Reports

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

(2019) Nora Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of CA Content and CPSF6 Dependence of Early HIV-1 Replication Complexes in SupT1-R5 Cells

(2019) Vojtech Zila et al.   mBio

HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS–STING-mediated NF-κB signalling

(2019) Jiaming Su et al.   Nature Microbiology

Highly Attenuated Infection With a Vpr-Deleted Molecular Clone of Human Immunodeficiency Virus-1

(2018) Ayub Ali et al.   JOURNAL OF INFECTIOUS DISEASES

Inhibiting the Ins and Outs of HIV Replication: Cell-Intrinsic Antiretroviral Restrictions at the Plasma Membrane

(2018) Toshana L. Foster et al.   Frontiers in Immunology

Ovarian Cancer Cells Commonly Exhibit Defective STING Signaling Which Affects Sensitivity to Viral Oncolysis

(2018) Nina Marí Gual Pimenta de Queiroz et al.   MOLECULAR CANCER RESEARCH

RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection

(2018) Yang Zhao et al.   Nature Communications

NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway

(2017) Run Fang et al.   JOURNAL OF IMMUNOLOGY

Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells

(2017) Caitlin M. Miller et al.   JOURNAL OF VIROLOGY

Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB

(2017) Jing Ye et al.   JOURNAL OF VIROLOGY

Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

(2017) Shilpa S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importin β1 targeting by hepatitis C virus NS3/4A protein restricts IRF3 and NF-κB signaling of IFNB1 antiviral response

(2017) Bridget Gagné et al.   TRAFFIC

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation

(2017) Dominik Hotter et al.   PLoS Pathogens

Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes

(2017) Ryan C. Burdick et al.   PLoS Pathogens

Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

(2017) Rebecca P. Sumner et al.   Frontiers in Immunology

Transmitted/Founder HIV-1 Subtype C Viruses Show Distinctive Signature Patterns in Vif, Vpr, and Vpu That Are Under Subsequent Immune Pressure During Early Infection

(2016) Raabya Rossenkhan et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis

(2016) Tianli Xia et al.   CANCER RESEARCH

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites

(2016) Shuting Xu et al.   Cell Host & Microbe

Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction

(2016) Toshana L. Foster et al.   Cell Host & Microbe

Molecular Mechanism of HIV-1 Vpr for Binding to Importin-α

(2016) Hideyuki Miyatake et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

(2016) David A. Jacques et al.   NATURE

The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

(2016) Ying Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages

(2016) Hichem Lahouassa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

(2016) Ying Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 + T Cells

(2016) Jolien Vermeire et al.   Cell Reports

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

(2016) Tianli Xia et al.   Cell Reports

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

(2016) Ashwanth C. Francis et al.   PLoS Pathogens

HIV-1 Vpr suppresses the cytomegalovirus promoter in a CRL4(DCAF1) E3 ligase independent manner

(2015) Xianjun Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vpr Overcomes Macrophage-Specific Restriction of HIV-1 Env Expression and Virion Production

(2015) Michael Mashiba et al.   Cell Host & Microbe

Signaling through RIG-I and type I interferon receptor: Immune activation by Newcastle disease virus in man versus immune evasion by Ebola virus (Review)

(2015) VOLKER SCHIRRMACHER   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING

(2015) Maud Trotard et al.   JOURNAL OF VIROLOGY

HIV Blocks Interferon Induction in Human Dendritic Cells and Macrophages by Dysregulation of TBK1

(2015) Andrew N. Harman et al.   JOURNAL OF VIROLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

(2014) Nadine Laguette et al.   CELL

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1

(2014) Wei Xu et al.   Cell Host & Microbe

Interactions between HIV-1 and the Cell-Autonomous Innate Immune System

(2014) Greg J. Towers et al.   Cell Host & Microbe

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

(2014) Arun K Mankan et al.   EMBO JOURNAL

G2/M Cell Cycle Arrest Correlates with Primate Lentiviral Vpr Interaction with the SLX4 Complex

(2014) Gregory Berger et al.   JOURNAL OF VIROLOGY

HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1

(2014) Ruikang Liu et al.   Retrovirology

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

LINE-1 Retrotransposable Element DNA Accumulates in HIV-1-Infected Cells

(2013) R. B. Jones et al.   JOURNAL OF VIROLOGY

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Structural basis of lentiviral subversion of a cellular protein degradation pathway

(2013) David Schwefel et al.   NATURE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

KPNB1,XPO7and IPO8 Mediate the Translocation ofNF-κB/p65 into the Nucleus

(2013) Peizhou Liang et al.   TRAFFIC

HIV-1 Vpr activates both canonical and noncanonical NF-κB pathway by enhancing the phosphorylation of IKKα/β

(2013) Ruikang Liu et al.   VIROLOGY

HIV Transmission

(2013) G. M. Shaw et al.   Cold Spring Harbor Perspectives in Medicine

Inhibition of NF-κB activity by HIV-1 Vpr is dependent on Vpr binding protein

(2012) Michael Kogan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quantification of Reverse Transcriptase Activity by Real-Time PCR as a Fast and Accurate Method for Titration of HIV, Lenti- and Retroviral Vectors

(2012) Jolien Vermeire et al.   PLoS One

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing

(2010) Will Fischer et al.   PLoS One

Formation of Mobile Chromatin-Associated Nuclear Foci Containing HIV-1 Vpr and VPRBP Is Critical for the Induction of G2 Cell Cycle Arrest

(2010) Jean-Philippe Belzile et al.   PLoS Pathogens

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

(2009) A. R. Stacey et al.   JOURNAL OF VIROLOGY

NF-κB p52, RelB and c-Rel are transported into the nucleus via a subset of importin α molecules

(2008) Riku Fagerlund et al.   CELLULAR SIGNALLING

Contribution of Ser386 and Ser396 to Activation of Interferon Regulatory Factor 3

(2008) Weijun Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Hantaan Virus Nucleocapsid Protein Binds to Importin   Proteins and Inhibits Tumor Necrosis Factor Alpha-Induced Activation of Nuclear Factor Kappa B

(2008) S. L. Taylor et al.   JOURNAL OF VIROLOGY

HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation

(2007) Atsushi Okumura et al.   VIROLOGY