A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing
Authors
Keywords
-
Journal
JOURNAL OF VIROLOGY
Volume 93, Issue 16, Pages -
Publisher
American Society for Microbiology
Online
2019-05-31
DOI
10.1128/jvi.00706-19
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes
- (2019) Douglas K. Fischer et al. JOURNAL OF VIROLOGY
- Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport
- (2018) Ashwanth C. Francis et al. Cell Host & Microbe
- HIV-1 activation of innate immunity depends strongly on the intracellular level of TREX1 and sensing of incomplete reverse transcription products
- (2018) Swati Kumar et al. JOURNAL OF VIROLOGY
- Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid
- (2018) Jiying Ning et al. JOURNAL OF VIROLOGY
- Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis
- (2018) Chantal L Márquez et al. eLife
- IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
- (2018) Donna L Mallery et al. eLife
- PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating
- (2018) Sanela Rankovic et al. JOURNAL OF VIROLOGY
- Inositol phosphates are assembly co-factors for HIV-1
- (2018) Robert A. Dick et al. NATURE
- Imaging HIV-1 Genomic DNA from Entry through Productive Infection
- (2017) Ryan D. Stultz et al. JOURNAL OF VIROLOGY
- Reverse Transcription Mechanically Initiates HIV-1 Capsid Disassembly
- (2017) Sanela Rankovic et al. JOURNAL OF VIROLOGY
- Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness
- (2017) Shilpa S. Iyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Capsid-Dependent Host Factors in HIV-1 Infection
- (2017) Masahiro Yamashita et al. TRENDS IN MICROBIOLOGY
- IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
- (2017) K. L. Jønsson et al. Nature Communications
- Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating
- (2017) Viacheslav Malikov et al. Cell Reports
- Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes
- (2017) Ryan C. Burdick et al. PLoS Pathogens
- Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?
- (2017) Rebecca P. Sumner et al. Frontiers in Immunology
- Mutations in CypA Binding Region of HIV-1 Capsid Affect Capsid Stability and Viral Replication in Primary Macrophages
- (2016) Laurentia C. Setiawan et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites
- (2016) Shuting Xu et al. Cell Host & Microbe
- Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74
- (2016) Akatsuki Saito et al. JOURNAL OF VIROLOGY
- Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus PassageIn Vivo
- (2016) Akatsuki Saito et al. JOURNAL OF VIROLOGY
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin
- (2016) Gregory A. Sowd et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIV-1 capsid is involved in post-nuclear entry steps
- (2016) Nan-Yu Chen et al. Retrovirology
- HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription
- (2016) Ophélie Cosnefroy et al. Retrovirology
- Molecular Architecture of the Retroviral Capsid
- (2016) Juan R. Perilla et al. TRENDS IN BIOCHEMICAL SCIENCES
- HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 + T Cells
- (2016) Jolien Vermeire et al. Cell Reports
- Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1
- (2016) Jonathan Maelfait et al. Cell Reports
- A Novel Entry/Uncoating Assay Reveals the Presence of at Least Two Species of Viral Capsids During Synchronized HIV-1 Infection
- (2016) Claire Da Silva Santos et al. PLoS Pathogens
- Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells
- (2016) Ashwanth C. Francis et al. PLoS Pathogens
- Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations
- (2016) Wei Wei et al. EBioMedicine
- PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1
- (2015) Sunnie M. Yoh et al. CELL
- HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry
- (2015) Jing Zhou et al. JOURNAL OF VIROLOGY
- Complementary Assays Reveal a Low Level of CA Associated with Viral Complexes in the Nuclei of HIV-1-Infected Cells
- (2015) Amy E. Hulme et al. JOURNAL OF VIROLOGY
- Innate immunity against HIV-1 infection
- (2015) Marcus Altfeld et al. NATURE IMMUNOLOGY
- Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
- (2015) Anna-Maria Herzner et al. NATURE IMMUNOLOGY
- HIV-1 assembly, release and maturation
- (2015) Eric O. Freed NATURE REVIEWS MICROBIOLOGY
- HIV-1 and interferons: who's interfering with whom?
- (2015) Tomas Doyle et al. NATURE REVIEWS MICROBIOLOGY
- HIV-1 capsid: the multifaceted key player in HIV-1 infection
- (2015) Edward M. Campbell et al. NATURE REVIEWS MICROBIOLOGY
- X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability
- (2015) A. T. Gres et al. SCIENCE
- Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8
- (2015) Shijian Zhang et al. VIROLOGY
- Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration
- (2015) Christopher R. Chin et al. Cell Reports
- Viral and cellular mechanisms of the innate immune sensing of HIV
- (2015) Xavier Lahaye et al. Current Opinion in Virology
- Interactions between HIV-1 and the Cell-Autonomous Innate Immune System
- (2014) Greg J. Towers et al. Cell Host & Microbe
- Functional Evidence for the Involvement of Microtubules and Dynein Motor Complexes in TRIM5 -Mediated Restriction of Retroviruses
- (2014) P. Pawlica et al. JOURNAL OF VIROLOGY
- Compensatory Substitutions in the HIV-1 Capsid Reduce the Fitness Cost Associated with Resistance to a Capsid-Targeting Small-Molecule Inhibitor
- (2014) Jiong Shi et al. JOURNAL OF VIROLOGY
- HIV-1 Uncoating Is Facilitated by Dynein and Kinesin 1
- (2014) Z. Lukic et al. JOURNAL OF VIROLOGY
- Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus Type 1 Capsid
- (2014) C. A. Guth et al. JOURNAL OF VIROLOGY
- Structural basis of HIV-1 capsid recognition by PF74 and CPSF6
- (2014) Akash Bhattacharya et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA
- (2014) Alberto De Iaco et al. Retrovirology
- BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid
- (2014) Thomas Fricke et al. Retrovirology
- HIV-1 uncoating: connection to nuclear entry and regulation by host proteins
- (2014) Zandrea Ambrose et al. VIROLOGY
- Cytoplasmic Dynein Promotes HIV-1 Uncoating
- (2014) Paulina Pawlica et al. Viruses-Basel
- A model for cofactor use during HIV-1 reverse transcription and nuclear entry
- (2014) Laura Hilditch et al. Current Opinion in Virology
- Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly
- (2014) Amanda J. Price et al. PLoS Pathogens
- Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid
- (2014) Ke Peng et al. eLife
- The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells
- (2013) Xavier Lahaye et al. IMMUNITY
- HIV-1 evades innate immune recognition through specific cofactor recruitment
- (2013) Jane Rasaiyaah et al. NATURE
- Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics
- (2013) Gongpu Zhao et al. NATURE
- Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex
- (2013) S. Stavrou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid
- (2013) Ernest L Yufenyuy et al. Retrovirology
- Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay
- (2013) Hongzhan Xu et al. Retrovirology
- Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
- (2013) D. Gao et al. SCIENCE
- HIV trafficking in host cells: motors wanted!
- (2013) Raphaël Gaudin et al. TRENDS IN CELL BIOLOGY
- Viral and Cellular Requirements for the Nuclear Entry of Retroviral Preintegration Nucleoprotein Complexes
- (2013) Kenneth Matreyek et al. Viruses-Basel
- HIV-1 Assembly, Budding, and Maturation
- (2013) W. I. Sundquist et al. Cold Spring Harbor Perspectives in Medicine
- Extreme Genetic Fragility of the HIV-1 Capsid
- (2013) Suzannah J. Rihn et al. PLoS Pathogens
- Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity
- (2013) Kenneth A. Matreyek et al. PLoS Pathogens
- Inhibition of Reverse Transcriptase Activity Increases Stability of the HIV-1 Core
- (2012) Y. Yang et al. JOURNAL OF VIROLOGY
- Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration
- (2012) Y. Koh et al. JOURNAL OF VIROLOGY
- The Host Proteins Transportin SR2/TNPO3 and Cyclophilin A Exert Opposing Effects on HIV-1 Uncoating
- (2012) V. B. Shah et al. JOURNAL OF VIROLOGY
- Quantification of Reverse Transcriptase Activity by Real-Time PCR as a Fast and Accurate Method for Titration of HIV, Lenti- and Retroviral Vectors
- (2012) Jolien Vermeire et al. PLoS One
- Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects
- (2012) Ruifeng Yang et al. Retrovirology
- Multiple roles of the capsid protein in the early steps of HIV-1 infection
- (2012) Ariberto Fassati VIRUS RESEARCH
- Bioactivity Determination of Native and Variant Forms of Therapeutic Interferons
- (2011) Louise Larocque et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- The Molecular Architecture of HIV
- (2011) John A.G. Briggs et al. JOURNAL OF MOLECULAR BIOLOGY
- The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid
- (2011) K. A. Matreyek et al. JOURNAL OF VIROLOGY
- Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages
- (2011) C. Ochsenbauer et al. JOURNAL OF VIROLOGY
- Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription
- (2011) A. E. Hulme et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency
- (2011) Torsten Schaller et al. PLoS Pathogens
- HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2
- (2011) Karen E. Ocwieja et al. PLoS Pathogens
- Flexible Use of Nuclear Import Pathways by HIV-1
- (2010) KyeongEun Lee et al. Cell Host & Microbe
- Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus
- (2010) Owen Pornillos et al. JOURNAL OF MOLECULAR BIOLOGY
- Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization
- (2010) J. Shi et al. JOURNAL OF VIROLOGY
- The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
- (2010) Nan Yan et al. NATURE IMMUNOLOGY
- Revisiting HIV-1 uncoating
- (2010) Nathalie Arhel Retrovirology
- HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention
- (2010) Wade S. Blair et al. PLoS Pathogens
- HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation
- (2009) Jhen Tsang et al. AIDS
- Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function
- (2009) In-Ja L. Byeon et al. CELL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More