CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

(2021) Jiali Yu et al.   NATURE MEDICINE

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Lipid metabolism in cancer: New perspectives and emerging mechanisms

(2021) Lindsay A. Broadfield et al.   DEVELOPMENTAL CELL

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

(2021) Xiaoqing Luo et al.   Cell Death & Disease

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

A single–cell type transcriptomics map of human tissues

(2021) Max Karlsson et al.   Science Advances

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

(2021) Han Zeng et al.   Molecular Metabolism

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells

(2020) Emily Clement et al.   EMBO JOURNAL

Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR

(2020) Ping Yang et al.   FASEB JOURNAL

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

(2020) Haiping Wang et al.   NATURE IMMUNOLOGY

Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis

(2020) Peishan Li et al.   NATURE IMMUNOLOGY

PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

(2020) Xiaozhe Yin et al.   Cell Reports

A lipase-independent pathway of lipid release and immune modulation by adipocytes

(2019) Stephen E. Flaherty et al.   SCIENCE

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

(2019) Chang Liu et al.   IMMUNITY

Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages

(2019) Hao Wu et al.   EMBO Molecular Medicine

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

(2019) Yuan Fang et al.   Nature Communications

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

CD36 deficiency attenuates immune-mediated hepatitis in mice by modulating the proapoptotic effects of CXC chemokine ligand 10

(2018) Che Xu et al.   HEPATOLOGY

CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis

(2018) Lei Zhao et al.   JOURNAL OF HEPATOLOGY

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression

(2018) Wei Xiang et al.   Nature Communications

Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway

(2018) Ping Yang et al.   CANCER LETTERS

CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis

(2018) Susanne Pfeiler et al.   FASEB JOURNAL

Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways

(2018) Qi-long Wang et al.   Theranostics

Mapping of phosphatidylserine recognition region on CD36 ectodomain

(2018) Sooram Banesh et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice

(2017) Ping Yang et al.   JOURNAL OF LIPID RESEARCH

Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC

(2017) Paul C. Tumeh et al.   Cancer Immunology Research

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

(2017) Amir A. Al-Khami et al.   OncoImmunology

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(2016) Sebastian R. Nielsen et al.   NATURE CELL BIOLOGY

Fatty Acid-Binding Protein E-FABP Restricts Tumor Growth by Promoting IFN-  Responses in Tumor-Associated Macrophages

(2014) Y. Zhang et al.   CANCER RESEARCH

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS