cGAS/cGAMP/STING signal propagation in the tumor microenvironment: Key role for myeloid cells in antitumor immunity

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes

(2021) Rachael E. Schwartz et al.   Aging-US

Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances anti-tumor immunity

(2021) Kathleen M. McAndrews et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment

(2021) Vera M. Kho et al.   CELLULAR IMMUNOLOGY

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

(2021) Álvaro de Mingo Pulido et al.   IMMUNITY

Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2′3′-Cyclic GMP–AMP and Cisplatin under Steady State and Inflammation

(2021) Xia Chen et al.   JOURNAL OF IMMUNOLOGY

Immune Modulation Plus Tumor Ablation: Adjuvants and Antibodies to Prime and Boost Anti-Tumor Immunity In Situ

(2021) Renske J. E. van den Bijgaart et al.   Frontiers in Immunology

Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity

(2021) Lise Chauveau et al.   EMBO REPORTS

STING Agonists as Cancer Therapeutics

(2021) Afsaneh Amouzegar et al.   Cancers

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

(2020) Yi Zhou et al.   IMMUNITY

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

(2020) Geneviève Pépin et al.   mBio

Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine

(2020) Chunju Fang et al.   Cellular & Molecular Immunology

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

(2020) Eslam Mohamed et al.   IMMUNITY

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

(2020) Chun Zhou et al.   IMMUNITY

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

(2020) Esther N. Arwert et al.   NATURE CELL BIOLOGY

Type I Interferon Response in Radiation-Induced Anti-Tumor Immunity

(2020) Faya Zhang et al.   SEMINARS IN RADIATION ONCOLOGY

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

(2020) Christina A. von Roemeling et al.   Nature Communications

The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance

(2020) Cristina P. R. Xavier et al.   Cells

cGAS-STING, an important pathway in cancer immunotherapy

(2020) Minlin Jiang et al.   Journal of Hematology & Oncology

Tumor-Derived cGAMP Regulates Activation of the Vasculature

(2020) Marco Campisi et al.   Frontiers in Immunology

In situ activation of STING pathway with polymeric SN38 for cancer chemoimmunotherapy

(2020) Jiayu Zhao et al.   BIOMATERIALS

Regulation of CD47 expression in cancer cells

(2020) Can-Yu Huang et al.   Translational Oncology

Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling

(2019) Ramya Nandakumar et al.   Nature Microbiology

ENPP1 in the Regulation of Mineralization and Beyond

(2019) Fiona Roberts et al.   TRENDS IN BIOCHEMICAL SCIENCES

cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity

(2019) Haipeng Liu et al.   EMBO REPORTS

SLC19A1 Is an Importer of the Immunotransmitter cGAMP

(2019) Christopher Ritchie et al.   MOLECULAR CELL

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

(2019) Carina C. de Oliveira Mann et al.   Cell Reports

HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

(2019) Shiying Wu et al.   NATURE CELL BIOLOGY

Extracellular Vesicles From KSHV-Infected Cells Stimulate Antiviral Immune Response Through Mitochondrial DNA

(2019) Hyungtaek Jeon et al.   Frontiers in Immunology

Exosome DNA: Critical regulator of tumor immunity and a diagnostic biomarker

(2019) Aman Sharma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SLC19A1 transports immunoreactive cyclic dinucleotides

(2019) Rutger D. Luteijn et al.   NATURE

Exosomes in Cancer Radioresistance

(2019) Jie Ni et al.   Frontiers in Oncology

Extracellular Vesicles in Modifying the Effects of Ionizing Radiation

(2019) Tünde Szatmári et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

(2019) Linda Schadt et al.   Cell Reports

Impact of Chemotherapy on Extracellular Vesicles: Understanding the Chemo-EVs

(2019) Nur' Syahada Ab Razak et al.   Frontiers in Oncology

STING signaling and host defense against microbial infection

(2019) Jeonghyun Ahn et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

(2018) Yasuhiro Kato et al.   ANNALS OF THE RHEUMATIC DISEASES

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells

(2018) Jeonghyun Ahn et al.   CANCER CELL

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production

(2018) Hiroyasu Konno et al.   ONCOGENE

Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect

(2018) María E. Rodríguez-Ruiz et al.   TRENDS IN IMMUNOLOGY

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

(2018) Julie M. Diamond et al.   Cancer Immunology Research

Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions

(2018) Yifan Wang et al.   Frontiers in Pharmacology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

(2018) Shunsuke Kitajima et al.   Cancer Discovery

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

(2017) Meng Michelle Xu et al.   IMMUNITY

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

(2017) Yuichi Kitai et al.   JOURNAL OF IMMUNOLOGY

STING, DCs and the link between innate and adaptive tumor immunity

(2017) Ralph E. Vatner et al.   MOLECULAR IMMUNOLOGY

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

(2017) Anne-lie Ståhl et al.   PEDIATRIC NEPHROLOGY

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

(2017) Xavier Sisquella et al.   Nature Communications

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis

(2016) Tianli Xia et al.   CANCER RESEARCH

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

VRACs and other ion channels and transporters in the regulation of cell volume and beyond

(2016) Thomas J. Jentsch   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA-Sensing and Nuclease Gene Expressions as Markers for Colorectal Cancer Progression

(2016) Chin-An Yang et al.   ONCOLOGY

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

(2016) Tianli Xia et al.   Cell Reports

Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

(2016) Ruihua Ma et al.   OncoImmunology

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Viruses transfer the antiviral second messenger cGAMP between cells

(2015) A. Bridgeman et al.   SCIENCE

Transmission of innate immune signaling by packaging of cGAMP in viral particles

(2015) Matteo Gentili et al.   SCIENCE

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

(2014) Xiaomei Wu et al.   NUCLEIC ACIDS RESEARCH

Cell-free Tumor Microparticle Vaccines Stimulate Dendritic Cells via cGAS/STING Signaling

(2014) H. Zhang et al.   Cancer Immunology Research

Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-κB induced cell death

(2013) Khyati Bhatelia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation

(2011) Takako Yoshida et al.   FREE RADICAL RESEARCH

The Suppressive Tumor Microenvironment: A Challenge in Cancer Immunotherapy

(2011) Elizabeth A. Vasievich et al.   MOLECULAR PHARMACEUTICS

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SLC19A1 pharmacogenomics summary

(2010) Sook Wah Yee et al.   Pharmacogenetics and Genomics

Immunotherapy of cancer

(2009) Hossein Borghaei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE