Review
Biochemistry & Molecular Biology
Theodora Karamanidou, Alexander Tsouknidas
Summary: This review summarizes the progress in the use of plant-derived extracellular vesicles as therapeutic delivery systems. Despite some controversies, plant-derived EVs show significant potential as nanodelivery systems of natural origin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hang Li, Shuya Zhao, Mian Jiang, Tong Zhu, Jinjian Liu, Guoxing Feng, Lu Lu, Jiali Dong, Xin Wu, Xin Chen, Yu Zhao, Saijun Fan
Summary: This study found that exosomes derived from mice exposed to total body irradiation can protect recipient mice against radiation-induced gut injury. MiR-142, highly expressed in exosomes, plays a key role in mediating the protective effect against radiation enteritis by improving the intestinal microenvironment. Biomodification of exosomes through enhancing miR-142 expression and intestinal specificity can further improve the protection against radiation enteritis.
Article
Engineering, Biomedical
Lilibeth Ortega-Pineda, Alec Sunyecz, Ana I. Salazar-Puerta, Maria Angelica Rincon-Benavides, Diego Alzate-Correa, Amrita Lakshmi Anaparthi, Elizabeth Guilfoyle, Louisa Mezache, Heather L. Struckman, Silvia Duarte-Sanmiguel, Binbin Deng, David W. McComb, Daniel J. Dodd, William R. Lawrence, Jordan Moore, Jingjing Zhang, Eduardo Reategui, Rengasayee Veeraraghavan, M. Tyler Nelson, Daniel Gallego-Perez, Natalia Higuita-Castro
Summary: Gene/oligonucleotide therapies have shown potential as a treatment strategy for neurological conditions, but current delivery methods have limitations. Extracellular vesicles (EVs) have emerged as a promising delivery vehicle, overcoming many of these limitations, including low permeability of the blood-brain barrier. This study provides a detailed understanding of the manufacturing process of neurogenic EVs and demonstrates their ability to enhance neuron-specific tropism and modulate electrophysiological activity. The study also suggests that surface decoration with glutamate receptors can facilitate enhanced delivery of EVs to the brain. Overall, these findings suggest that designer EVs loaded with specific factors can be a promising nanotechnology platform to drive pro-neuronal responses.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Cell & Tissue Engineering
Lan Luo, Chen Yan, Naoki Fuchi, Yukinobu Kodama, Xu Zhang, Goto Shinji, Kiyonori Miura, Hitoshi Sasaki, Tao-Sheng Li
Summary: The study explored the hypothesis that altered secretion of extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) triggered radiation-induced heart disease. Results indicated that EVs from irradiated MSCs exhibited changed miRNA profiles and harmful effects on heart cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Biomedical
Bianca Dumontel, Carla Jimenez-Jimenez, Maria Vallet-Regi, Miguel Manzano
Summary: The integration of artificial nanoplatforms with natural bio-materials has led to the development of more efficient drug delivery systems. In this study, mesoporous silica nanoparticles (MSNs) were combined with tumor derived extracellular vesicles (EVs) to create a hybrid nanosystem that showed selective cellular internalization and enhanced intracellular drug accumulation, making it a promising candidate for targeted treatments.
MATERIALS TODAY BIO
(2023)
Article
Immunology
Roland F. Seim, Laura E. Herring, Angie L. Mordant, Micah L. Willis, Shannon M. Wallet, Leon G. Coleman Jr, Robert Maile
Summary: Acute radiation syndrome (ARS) is characterized by immune dysfunction and organ failure caused by high doses of ionizing radiation. This study explored the role of extracellular vesicles (EVs) in ARS and their potential as diagnostic markers and radioprotectants. The researchers found that EV cargo could indicate the occurrence and severity of whole body irradiation (WBIR) exposure. Mesenchymal stem cell-derived EVs (MSC-EVs) were shown to alleviate immune dysfunction and prolong survival in mice exposed to lethal levels of radiation. These findings highlight the importance of EVs in ARS and suggest their potential therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Munira Kadhim, Seda Tuncay Cagatay, Eman Mohammed Elbakrawy
Summary: Radiation-induced non-targeted effects play a significant role in radiation biology, with extracellular vesicles like exosomes potentially carrying nucleic acids and proteins as mediators of these effects. Current literature suggests that ionizing radiation can modulate the release and cargo content of exosomes, leading to functional changes in recipient cells. However, there are still significant gaps in our understanding, particularly regarding the modified exosome cargo post radiation exposure and the induced functional changes in recipient cells.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Review
Food Science & Technology
Qiao Jiang, Li Wang, Jinlong Tian, Weijia Zhang, Huijun Cui, Hailong Gui, Zhihuan Zang, Bin Li, Xu Si
Summary: Extracellular vesicles (EVs) are non-replicating particles released from cells, known for their health-promoting effects and potential as drug carriers. While culture-cell-derived EVs have limitations, food-derived EVs (FDEVs) offer unique advantages. This review comprehensively analyzes the biogenesis, composition, and health benefits of FDEVs, as well as techniques for oral delivery systems. It also discusses the advantages, challenges, and current research in delivering active phytoconstituents using FDEVs. Technical innovation and quality control standardization are crucial for promoting FDEVs development.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Natalia Simionescu, Radu Zonda, Anca Roxana Petrovici, Adriana Georgescu
Summary: Extracellular vesicles (EVs) play a critical role in the development and treatment resistance of glioblastoma (GB), potentially serving as diagnostic, prognostic, and disease monitoring biomarkers, as well as gene therapy nanocarriers.
Review
Biochemistry & Molecular Biology
Sarah A. Walsh, Benjamin W. Hoyt, Cassie J. Rowe, Devaveena Dey, Thomas A. Davis
Summary: Severe polytraumatic injury can lead to immune dysfunction, but early biomarkers for immune dysfunction are currently lacking. Study of exosomal cargo may provide critical insights for intervention.
Article
Chemistry, Multidisciplinary
Ana I. I. Salazar-Puerta, Maria A. Rincon-Benavides, Tatiana Z. Z. Cuellar-Gaviria, Julian Aldana, Gabriela Vasquez Martinez, Lilibeth Ortega-Pineda, Devleena Das, Daniel Dodd, Charles A. A. Spencer, Binbin Deng, David W. W. McComb, Joshua A. A. Englert, Samir Ghadiali, Diana Zepeda-Orozco, Loren E. E. Wold, Daniel Gallego-Perez, Natalia Higuita-Castro
Summary: Acute respiratory distress syndrome (ARDS) is a burden to the healthcare system, causing severe hypoxemia and inflammatory response. This study demonstrates the potential of engineered extracellular vesicles (eEVs) derived from dermal fibroblasts for nonviral delivery of anti-inflammatory payloads to the inflamed/injured lung. The results show that SPA-functionalized IL-4- and IL-10-loaded eEVs can reduce inflammation and tissue damage in vitro and in vivo, with significant changes in the metabolic profile of the inflamed lungs.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xian Wu, Tang Tang, Yushuang Wei, Katherine A. Cummins, David K. Wood, Hong-Bo Pang
Summary: This study develops a collagen-based three-dimension assay to quantify and understand the intercellular exchange of nanoparticles (NPs). The results demonstrate the significant role of extracellular vesicles (EVs) in NP transport, providing insights into the importance of EVs in NP delivery into complex tissues.
Review
Cell Biology
Yuyun Jiang, Xi Liu, Jixian Ye, Yongbin Ma, Jiahui Mao, Dingqi Feng, Xuefeng Wang
Summary: This review summarizes the discovery, formation mechanisms, isolation, identification, and mediation of cellular communication in migrasomes, which are newly discovered extracellular vesicles. In addition to their roles in various biological processes, migrasomes have been found to play a significant role in mediating different pathological processes. The potential of migrasomes for disease diagnosis and treatment is also discussed.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Cell Biology
Fumihiko Urabe, Kalyani Patil, Grant A. Ramm, Takahiro Ochiya, Carolina Soekmadji
Summary: Distant organ metastasis, orchestrated by complex biological interactions, is a fundamental feature of malignant tumors. Extracellular vesicles (EVs) play a critical role in mediating tumor-host cell interactions, controlling organ-specific infiltration, adaptation, and colonization at the secondary site.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Review
Chemistry, Physical
Jie Wu, Lei Ma, Danni Sun, Xinru Zhang, Jiwei Cui, Yingjiang Du, Yumiao Guo, Xue Wang, Liuqing Di, Ruoning Wang
Summary: This review discusses the application of extracellular vesicles (EVs) in the treatment of brain disorders and the new strategies for bioengineering EVs. It provides detailed descriptions of the properties and biogenesis of different subtypes of EVs, and compares EVs with other brain-targeted nanocarriers.
Article
Biology
Rita Hargitai, Paivi Roivainen, David Kis, Jukka Luukkonen, Geza Safrany, Jan Seppala, Tunde Szatmari, Tuomas Viren, Kristiina Vuolukka, Sisko Salomaa, Katalin Lumniczky
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2020)
Article
Oncology
B. Frey, J. Mika, K. Jelonek, L. Cruz-Garcia, C. Roelants, I Testard, N. Cherradi, K. Lumniczky, S. Polozov, A. Napieralska, P. Widlak, U. S. Gaipl, C. Badie, J. Polanska, S. M. Candelas
STRAHLENTHERAPIE UND ONKOLOGIE
(2020)
Article
Environmental Sciences
Katalin Lumniczky, Nathalie Impens, Gemma Armengol, Serge Candeias, Alexandros G. Georgakilas, Sabine Hornhardt, Olga A. Martin, Franz Roedel, Doerthe Schaue
Summary: Ionizing radiation interacts with the immune system in complex ways, potentially altering immune fitness and accelerating immune senescence at low doses. However, low dose radiation therapy has beneficial effects in certain diseases, providing relief from pain and inflammation.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Rita Hargitai, David Kis, Eszter Persa, Tunde Szatmari, Geza Safrany, Katalin Lumniczky
Summary: The study shows that extracellular vesicles (EVs) from irradiated mice can affect the redox status and expression of radiation-response genes in bystander mice. Irradiation with 2 Gy leads to increased lipid peroxidation and altered gene expression. EVs cause decreased expression of antioxidant enzyme genes and iNOS2 in bystander mice.
Editorial Material
Oncology
Geza Safrany, Katalin Lumniczky, Lorenzo Manti
Review
Health Care Sciences & Services
Katalin Balazs, Lilla Antal, Geza Safrany, Katalin Lumniczky
Summary: Prostate cancer is a common cancer in men, often discovered in advanced stages. Current screening methods have limitations and there is a need for more accurate liquid biopsy markers. By discussing circulating tumor cells, extracellular vesicles with microRNA content, as well as immune and inflammation-related markers in blood, better diagnosis and treatment prediction for prostate cancer can be achieved.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
David Kis, Ilona Barbara Csordas, Eszter Persa, Balint Jezso, Rita Hargitai, Tuende Szatmari, Nikolett Sandor, Eniko Kis, Katalin Balazs, Geza Safrany, Katalin Lumniczky
Summary: This study investigated the role of bone marrow-derived extracellular vesicles (EVs) in mediating bystander effects induced by ionizing radiation (IR). The results showed that only EVs from an early stage of radiation damage were able to transmit IR-induced bystander effects.
Article
Oncology
Katalin Balazs, Zsuzsa S. Kocsis, Peter Agoston, Kliton Jorgo, Laszlo Gesztesi, Gyongyi Farkas, Gabor Szekely, Zoltan Takacsi-Nagy, Csaba Polgar, Geza Safrany, Zsolt Juranyi, Katalin Lumniczky
Summary: The development of cancer and anti-cancer therapies can lead to systemic immune alterations, but little is known about how long these alterations persist in cancer survivors. A study on prostate cancer patients revealed that some immune alterations did not recover after treatment, while others persisted or worsened, emphasizing the need for further research to understand the causes and long-term consequences of these immune changes.
Article
Biochemistry & Molecular Biology
Ilona Barbara Csordas, Eric Andreas Rutten, Tuende Szatmari, Prabal Subedi, Lourdes Cruz-Garcia, David Kis, Balint Jezso, Christine von Toerne, Martina Forgacs, Geza Safrany, Soile Tapio, Christophe Badie, Katalin Lumniczky
Summary: Extracellular vesicles (EVs) play an important role in mediating bystander responses in irradiated bone marrow by altering cellular pathways through the miRNAs they carry. Using a mouse model, we analyzed the miRNA content of BM-derived EVs from mice irradiated with different doses and investigated the proteomic changes in BM cells upon direct irradiation or treatment with EVs. We identified key cellular processes regulated by miRNAs and suggested potential candidates involved in the regulation of these bystander processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
David Kis, Eszter Persa, Tunde Szatmari, Lilla Antal, Attila Bota, Ilona Barbara Csordas, Rita Hargitai, Balint Jezso, Eniko Kis, Judith Mihaly, Geza Safrany, Zoltan Varga, Katalin Lumniczky
BRITISH JOURNAL OF RADIOLOGY
(2020)