The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases

Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans

(2016) Wei-Ching Huang et al.   FASEB JOURNAL

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

(2015) Michael S. Donoviel et al.   FASEB JOURNAL

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice

(2015) Su-Yeon Lee et al.   HEPATOLOGY

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

(2015) Masayuki Nagahashi et al.   HEPATOLOGY

Uncleaved ApoM Signal Peptide Is Required for Formation of Large ApoM/Sphingosine 1-Phosphate (S1P)-enriched HDL Particles

(2015) Mingxia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line

(2015) Runping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage response and sphingolipid signaling in liver diseases

(2015) Masayuki Nagahashi et al.   SURGERY TODAY

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

(2015) N C Hait et al.   Oncogenesis

Bile acid signaling and biliary functions

(2015) Hannah Jones et al.   Acta Pharmaceutica Sinica B

Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism

(2015) Eric Kwong et al.   Acta Pharmaceutica Sinica B

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate

(2014) Andreas V. Thuy et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Export of sphingosine-1-phosphate and cancer progression

(2014) Kazuaki Takabe et al.   JOURNAL OF LIPID RESEARCH

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy

(2014) Masayuki Nagahashi et al.   Biomed Research International

Molecular and physiological functions of sphingosine 1-phosphate transporters

(2013) Tsuyoshi Nishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Sphingosine 1-phosphate signalling

(2013) K. Mendelson et al.   DEVELOPMENT

Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

(2013) D.-H. Nguyen-Tran et al.   Disease Models & Mechanisms

Sphingosine-1-phosphate receptor 2

(2013) Mohamad Adada et al.   FEBS Journal

Hepatic Apolipoprotein M (ApoM) Overexpression Stimulates Formation of Larger ApoM/Sphingosine 1-Phosphate-enriched Plasma High Density Lipoprotein

(2013) Mingxia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice

(2013) Abdel K. Salous et al.   JOURNAL OF LIPID RESEARCH

Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent

(2013) Kai Liu et al.   PLoS One

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Evidence for a link between histone deacetylation and Ca2+homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts

(2012) Katja Ihlefeld et al.   BIOCHEMICAL JOURNAL

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

(2012) M. Nagahashi et al.   CANCER RESEARCH

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

(2012) Masayuki Nagahashi et al.   FASEB JOURNAL

The Role of Sphingosine-1-Phosphate in Breast Cancer Tumor-Induced Lymphangiogenesis

(2012) Tomoyoshi Aoyagi et al.   Lymphatic Research and Biology

Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts

(2011) Vladimir Beljanski et al.   CANCER BIOLOGY & THERAPY

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Impact of bile acids on the growth of human cholangiocarcinoma via FXR

(2011) Jiaqi Dai et al.   Journal of Hematology & Oncology

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

(2010) Kazuaki Takabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via Gαi-protein-coupled receptors and the AKT pathway

(2010) Risheng Cao et al.   JOURNAL OF LIPID RESEARCH

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation

(2009) J. Miao et al.   GENES & DEVELOPMENT

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS