Article
Chemistry, Physical
Tatyana V. Volkova, Olga R. Simonova, German L. Perlovich
Summary: This study investigates the physicochemical properties of the novel potential antifungal compound TZD in the presence of 2HP-beta-CD, focusing on solubility, distribution, and membrane permeability. The experiments were carried out at different temperatures and pH values to predict the behavior of TZD in biological media. The results provide insights into the role of hydrogen bonding and the permeation of TZD across stomach and intestine membranes.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Medicinal
Muhammad Shah, Muhammad Saeed Jan, Abdul Sadiq, Sara Khan, Umer Rashid
Summary: Metabolic disorders like Diabetes mellitus (DM) can be treated by targeting abnormally expressed key enzymes. A vanillin-thiazolidine-2,4-dione hybrid compound was reported as a multitarget inhibitor, but only showed good in-vitro DPP-4 inhibition. Current research aims to optimize this lead compound for diabetes treatment by manipulating multiple pathways simultaneously.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Maria Stefania Sinicropi, Jessica Ceramella, Patrice Vanelle, Domenico Iacopetta, Camillo Rosano, Omar Khoumeri, Shawkat Abdelmohsen, Wafaa Abdelhady, Hussein El-Kashef
Summary: Cancer is a complex disease and developing new compounds for cancer treatments is urgently needed. In recent years, the design and synthesis of innovative hybrid molecules have gained interest, with promising results in inhibiting cancer cells. The tested hybrid compounds containing trimethoxybenzene, thiazolidinedione and thiazole showed good efficacy against breast cancer cells, with compound 7e being the most effective. Docking simulations indicated that these compounds may target human Topoisomerases I and II, and enzymatic assays confirmed their inhibitory activity. Compound 7e was found to induce apoptosis in MCF-7 cells. These findings support further research in designing and synthesizing analogues for anticancer purposes.
Review
Medicine, Research & Experimental
Srinivasa R. Vulichi, Atul Kabra, Rupak Kumar, Kapur Suman, Chunduri Venkata Rao, Natalia Cruz-Martins
Summary: Glitazones are synthetic derivatives of thiazolidinedione that primarily act on peroxisome proliferator-activated receptor-gamma (PPAR-y) receptors to regulate metabolic pathways linked to glucose and lipid metabolism at a transcriptional level. Despite their high efficacy and selectivity in clinical settings, glitazones are restricted for long-term usage due to potential adverse effects such as weight gain and heart-related complications.
Article
Biochemistry & Molecular Biology
Musherah M. Alshammari, Raoudha Soury, Khalaf M. Alenezi, Md. Mushtque, M. Moshahid Alam Rizvi, Ashanul Haque
Summary: A new pyrazole-tethered thiazolidine-2,4-dione derivative was synthesized and its structure was confirmed by spectroscopic techniques. Density functional theory calculations were used to determine the molecular features. In vitro cytotoxicity studies showed higher activity and lower toxicity of the compound against breast cancer cell line.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Organic
Sai Krishna Chilaka, Krishna Prasad Chinthapally, Anil Kumar Soda, Ramesh Kumar Chellu, Srinivas Kurva, Jagadeesh Babu Nanubolu, Sridhar Madabhushi
Summary: In this study, protocols for the synthesis of 1,2,4-triazoles and 1,3,4-thiadiazinones were developed using [3+2] and [3+3] domino annulation reactions of nitrile imines with succinimide and thiazolidine-2,4-dione, respectively. The reactions were conducted in the presence of a base and alcohol as a solvent. Notably, the alcohol also reacted to form ester functionality in the products. These methodologies provide a metal-free and direct approach to the synthesis of 1,2,4-triazoles and 1,3,4-thiadiazinones with high yields and a wide range of substrates under mild conditions.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hazem Elkady, Osama A. El-Dardir, Alaa Elwan, Mohammed S. Taghour, Hazem A. Mahdy, Mohammed A. Dahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Dalal Z. Husein, Elsayed E. Hafez, Amira M. G. Darwish, Ahmed M. Metwaly, Ibrahim H. Eissa
Summary: In this study, novel VEGFR-2-targeting thiazolidine-2,4-dione derivatives were designed and synthesized. The compounds demonstrated potent anti-VEGFR-2 activity and inhibited the growth of three different cancer cell types. Compound 15 showed the best anti-VEGFR-2 potency and exhibited remarkable anti-proliferative activities against the tested cancer cell lines. Computational methods were used to analyze the molecular characteristics of the VEGFR-2-15 complex, and ADMET and toxicity experiments were conducted to evaluate the therapeutic potential of the synthesized compounds. The findings suggest that compound 15 may serve as an effective anticancer lead compound.
Article
Biochemistry & Molecular Biology
Musherah M. Alshammari, Raoudha Soury, Khalaf M. Alenezi, Md Mushtque, M. Moshahid Alam Rizvi, Ashanul Haque
Summary: A new pyrazole-tethered thiazolidine-2,4-dione derivative was synthesized and displayed higher activity and lower toxicity towards breast cancer cell line compared to its intermediate compound. The study also involved spectroscopic confirmation, theoretical calculations, in vitro cytotoxicity testing, and complementary docking and ADME studies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Physical
Svetlana Blokhina, Angelica Sharapova, Marina Ol'khovich, Igor B. Levshin, German L. Perlovich
Summary: The novel antimicrobial agent (5Z)-3-(3-(4-acetylpiperazin-1-yl)-2-hydroxypropyl)-5-(4-chlorobenzylidene)thiazolidine-2,4-dione was synthesized, and its solubility was found to increase with temperature. The distribution process of the compound in two-phase systems was described as thermodynamically favorable, endothermic, and entropy-driven.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Bo Jiang, Jiao Luo, Shuju Guo, Lijun Wang
Summary: In this study, molecules containing 2,4-thiazolidinedione and hydantoin were designed, synthesized and evaluated for PTP1B inhibitory potency. Compound 5a was identified as a potent PTP1B inhibitor with selectivity over TCPTP, leading to improvements in blood glucose levels, insulin sensitivity, liver glycogen storage, and pancreatic islet structure in diabetic mice. These results suggest that compound 5a could be a promising lead compound for new antidiabetic drug discovery.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Khaled El-Adl, Helmy Sakr, Sanadelaslam S. A. El-Hddad, Abdel-Ghany A. El-Helby, Mohamed Nasser, Hamada S. Abulkhair
Summary: The study evaluated the anticancer activity of novel thiazolidine-2,4-diones against several cancer cell lines, with some derivatives showing high inhibitory effects on HCT-116, HepG2, and MCF-7 cells. Some derivatives also displayed potential inhibitory effects against VEGFR-2. These compounds demonstrated promising characteristics as potential anticancer drug candidates.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Multidisciplinary
Bushra Ansari, Haroon Khan, Muhammad Saeed Jan, Khalaf F. Alsharif, Khalid J. Alzahrani, Umer Rashid, Abdul Saboor Pirzada
Summary: Various derivatives of thiazolidine-2,4-dione (C1-C5) were synthesized through chemical reaction and modification, and their chemical structures were determined by NMR spectroscopy. In silico ADME studies revealed the pharmacokinetic properties of the compounds, including rotatable bonds, lipophilicity, water solubility, GI absorption, blood-brain barrier permeability, and drug metabolism. The study also evaluated the drug likeness properties of the derivatives. The results suggest that these compounds have potential for improving pharmacokinetic profiles and reducing toxicity.
JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yingying Zheng, Mengyu Li, Simin Wu, Lu Li, Zhuang Xiong, Xuetao Xu, Kun Zhang, Yi Wen
Summary: A series of chromone-thiazolidine-2,4-dione derivatives were synthesized and tested for their a-glucosidase inhibitory activity. Compound e28 showed the strongest inhibitory activity, which was reversible and non-competitive. Further studies revealed that e28 had good safety.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Gabriel Marc, Anca Stana, Adrian Pirnau, Laurian Vlase, Smaranda Oniga, Ovidiu Oniga
Summary: The study discusses the importance of thiazolidine-2,4-dione in medicinal chemistry and the synthesis of its derivatives through N-alkylation and O-alkylation reactions. Experimental results indicate the formation of N-alkylated derivatives under reaction conditions, providing a new pathway for the synthesis of biologically active compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Li Lu, Chunmei Hu, Xiaofeng Min, Zhong Liu, Xuetao Xu, Lishe Gan
Summary: A new tyrosinase inhibitor with anti-melanogenic activity was discovered through the synthesis of a series of derivatives. The compound showed inhibitory activity against tyrosinase and could suppress melanogenesis both in cells and in a zebrafish model.
Article
Materials Science, Multidisciplinary
Xiaoyang Xuan, Min Qian, Likun Pan, Ting Lu, Yang Gao, Yueping Niu, Shangqing Gong
Summary: This article introduces a flexible battery with a smart electrochromic function and designs a Ni // Zn battery with an electricity visual alerting function. The battery has a high energy density and reversible color change, allowing for visual monitoring of the battery's residual electricity.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Kui Pan, Jie Sun, Chang Lin, Liying Deng, Xiao Li, Zuodong Mao, Tianxi Yang, Zhonghang Huang, Yang Li, Junyang Nie, Tailiang Guo, Qun Yan
Summary: Based on transfer printing technology, micro-LED pixels can be transferred to different driving substrates to achieve displays with various applications. The separation of GaN-based micro-LEDs from the original substrate is achieved using conventional laser lift-off techniques. The pixels are then transferred to a flexible tape and further onto an intermediate and rigid substrate using a sacrificial layer for assistance. Experimental results demonstrate efficient transfer with the potential for further transfer to different types and sizes of driving substrates using a suitable transfer stamp.
Article
Chemistry, Multidisciplinary
Aochen Du, Wenxiao Zhao, Yu Peng, Xinzhi Qin, Zexi Lin, Yun Ye, Enguo Chen, Sheng Xu, Tailiang Guo
Summary: We successfully prepared a series of Mn2+ doped CsPbBr3 perovskite quantum dots (PQDs) in glasses by melt quenching and in situ crystallization technique. The PQDs exhibited a slight red shift and broadening of emission due to the Mn2+ transition. These PQDs@glasses showed excellent thermal stability and a high exciton binding energy level. By first principles calculations, the changes of electronic structure after Mn doping in CsPbBr3 were demonstrated. Finally, we designed a contactless electroluminescence device with the PQDs@glasses for distance detection in sterile and dust-free environments.
Article
Nanoscience & Nanotechnology
Zhiqi Luo, Yongshen Yu, Kaiyu Yang, Lihua Lin, Jintang Lin, Tailiang Guo, Hailong Hu, Fushan Li
Summary: High-performance cadmium-free ZnSe/ZnS quantum dot light-emitting diodes (QLEDs) are achieved by constructing a double organic hole-transport layer, leading to improved carrier balance and higher external quantum efficiency.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Crystallography
Zibin Lin, Haonan Jiang, Daochun Ye, Wenyan Zhang, Enguo Chen, Yun Ye, Sheng Xu, Qun Yan, Tailiang Guo
Summary: This paper presents a zero-optical-distance mini-LED backlight with cone-shaped light coupling microstructures to achieve an ultra-thin backlight architecture. The illuminance uniformity and light extraction efficiency of the whole structure reach 91.47% and 77.09%, respectively. The structure shows high optical performance while reducing the thickness of the backlight module, which is of great significance for the development of mini-LED backlights.
Article
Chemistry, Physical
Wenjie Lu, Qizhen Chen, Huaan Zeng, Hui Wang, Lujian Liu, Tailiang Guo, Huipeng Chen, Rui Wang
Summary: An all-optical synaptic device based on a long-afterglow material is reported, which has optical properties similar to biological synapses. Combining the focusing characteristics of a convex lens, the optical summation of all-optical synaptic array pixels can be completed to transmit preprocessed multiple input signals. This work enriches the variety of artificial synapses and demonstrates the great development potential of photoelectric artificial neural networks.
Article
Optics
Bingle Huang, Nan Zha, Enguo Chen, Tailiang Guo
Summary: This paper presents a patternable two-color quantum dot (QD) color conversion film prepared by photolithography technique. The toluene-assisted dispersion of QD powder with the best performance matching was selected. The experimental results show that the height of the patternable QD microstructures has good consistency and the photolithographic process does not significantly affect the spectral characteristics of QDs. Therefore, the preparation methods described in this paper can provide a reference for related research.
OPTICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Qiaocan Huang, Zunxian Yang, Yuanqing Zhou, Yuliang Ye, Bingqing Ye, Zihong Shen, Wenbo Wu, Zongyi Meng, Zhiwei Zeng, Hongyi Hong, Songwei Ye, Zhiming Cheng, Qianting Lan, Jiaxiang Wang, Ye Chen, Hui Zhang, Tailiang Guo, Fushan Li, Yongyi Chen, Zhenzhen Weng
Summary: Quantum dots (QDs) with a CdSe@ZnS/ZnS alloy shell have great potential as emitters for opto-electronic devices due to their narrow FWHM, high color purity, and tunable wavelength. This study optimized the core growth and cladding process of QDs to obtain high-quality QDs and used 1-Octanethiol (OT) as ligands to improve their stability. The morphology, colloidal stability, and luminescence performance were analyzed in detail. The green CdSe@ZnS/ZnS QLEDs achieved a peak luminescence of 361,850 cd/m2 and a current efficiency (CE) of 33 cd/A by reducing defect state densities and prolonging carrier lifetimes. This work enhances our understanding of the relationship between defect state density and QD performance for the design and fabrication of high-performance light-emitting diodes.
Article
Materials Science, Multidisciplinary
Yibin Lin, Wandi Chen, Jinyu Ye, Jinjie Xu, Xinyan Gan, Yuyan Peng, Xiongtu Zhou, Tailiang Guo, Yongai Zhang, Chaoxing Wu
Summary: In this work, a novel single-electrode mode alternating current electroluminescence device with epidermal potential as another stimulation electrode (EPSE-ACEL) is proposed for the simultaneous sensing and display of biological information. The EPSE-ACEL device, consisting of a composited emissive layer and a transparent electrode, can be easily attached to any position on the human body and self-powered by natural triboelectrification and static charges. It is demonstrated that the EPSE-ACEL device can be used in fingerprint display and wireless wearable display, showing promising applications in human-computer interaction, health-care monitoring, and intelligent wearable equipment.
Article
Chemistry, Physical
Wandi Chen, Wenwen Wang, Shiyao Li, Jiaxin Kang, Yongai Zhang, Qun Yan, Tailiang Guo, Xiongtu Zhou, Chaoxing Wu
Summary: Liquid crystal (LC) is an intermediate state compound with both the anisotropy of crystal molecules and the fluidity of liquid, making it a cutting-edge technology in optoelectronics. The need for a safe and portable low-power device is evident, given the requirement for larger voltages and the safety concerns associated with large-aperture LC lens. This paper proposes a Feather TENG (F-TENG) that utilizes feathers as friction materials to harvest mechanical energy and power experimental test equipment, offering a simple and affordable method for the practical application of TENG systems.
Article
Chemistry, Physical
Hui Wang, Zhichao Rao, Yaqian Liu, Liuting Shan, Tailiang Guo, Huipeng Chen, Rui Wang
Summary: In this study, a highly stretchable dual-mode triboelectric nanogenerator (SDTENG) with both stretch-insensitive sensing and stretch-sensitive sensing properties is proposed. By regional modulus modulation based on cross-linked interpenetrating network (IPN), our SDTENG shows almost the same pressure sensing property in the 120% stretch range, while the MXene/CNT electrode exhibits excellent strain sensitivity. The combination of stretch-insensitive pressure sensing and stretch-sensitive strain sensing makes our SDTENG a promising candidate for wearable devices and smart robots.
Article
Nanoscience & Nanotechnology
Kaiyu Yang, Jinliang Mao, Jinping Zheng, Yongshen Yu, Baolin Xu, Qingkai Zhang, Xukeng Weng, Qiuxiang Lin, Tailiang Guo, Fushan Li
Summary: By introducing rubidium bromide (RbBr) to tune the crystallization kinetics of quasi-2D perovskites, more uniform phase distribution is achieved, and surface defects are effectively passivated, leading to significant improvement in photoluminescence quantum yield and external quantum efficiency of PeLEDs.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Physics, Applied
Ziming Song, Qi Li, Yabin Yan, Yang Gao, Fuzhen Xuan
Summary: This study developed a crack-based strain sensor using carbon nanotube-silicon oxide/polydimethylsiloxane (CNT-SiOx/PDMS), and established an electro-mechanical mathematical model to analyze the relationship between strain, crack density, and device sensitivity. The results revealed that crack density affects the distribution and quantity of conductive elements, and stress applied to the device leads to a reduction in the conductive path and an increase in sensitivity for the strain sensor.
APPLIED PHYSICS LETTERS
(2023)
Article
Optics
Liu Lan, Ye Yun, Guo Tailiang
Summary: This paper proposes a detection method for OLED pixel defects based on an extended FPN. By extending the FPN, regional details at different levels of the hierarchy are effectively obtained, and the semantic information from higher levels is integrated in a pyramidal manner to enrich the underlying features and enhance the contrast of details, thereby achieving more accurate detection of OLED pixel defects.
ACTA OPTICA SINICA
(2023)
Article
Engineering, Electrical & Electronic
Kuan Ju, Shuo Weng, Chun Li, Lihui Zhao, Bo Li, Yue Hu, Yang Gao, Fuzhen Xuan
Summary: This paper presents an intelligent monitoring method for continuous monitoring of dynamic load parameters and load recognition in hydrogen-based fuel cell vehicles (HFCVs) using carbon-based strain sensor, data acquisition and wireless transmission embedded unit, and machine learning. The research shows that this method can effectively recognize different road conditions and optimize the structure of the deep neural network.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)