Daphnetin Attenuated Cisplatin-Induced Acute Nephrotoxicity With Enhancing Antitumor Activity of Cisplatin by Upregulating SIRT1/SIRT6-Nrf2 Pathway

Daphnetin alleviates lipopolysaccharide/ d -galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-κB, and the induction of autophagy

(2018) Hongming Lv et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling

(2018) Zhongchi Li et al.   KIDNEY INTERNATIONAL

Kidney Protection Effect of Ginsenoside Re and Its Underlying Mechanisms on Cisplatin-Induced Kidney Injury

(2018) Zi Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy

(2018) Meng-Yu Wu et al.   Oxidative Medicine and Cellular Longevity

Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-κB and improving mitochondrial function

(2018) Xiaowen Yu et al.   EBioMedicine

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

(2018) Qing-Yu Zhang et al.   Frontiers in Pharmacology

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide ( t -BHP)-induced mitochondrial dysfunction and cell death

(2017) Hongming Lv et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation

(2017) Wei Zhang et al.   NEUROSCIENCE

C-Jun N-terminal kinase signalling pathway in response to cisplatin

(2016) Dong Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The complex role of SIRT6 in carcinogenesis

(2015) Batia Lerrer et al.   CARCINOGENESIS

Baicalein attenuates renal fibrosis by inhibiting inflammation via down-regulating NF-κB and MAPK signal pathways

(2015) Wei Wang et al.   JOURNAL OF MOLECULAR HISTOLOGY

Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling

(2015) Iva Potočnjak et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1

(2015) Zhuangzhi Meng et al.   Experimental and Therapeutic Medicine

Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation

(2015) Yong-Min Choi et al.   PLoS One

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice

(2013) Gi-Su Oh et al.   KIDNEY INTERNATIONAL

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update

(2012) Neife Aparecida Guinaim dos Santos et al.   ARCHIVES OF TOXICOLOGY

Dimethylfumarate Attenuates Renal Fibrosis via NF-E2-Related Factor 2-Mediated Inhibition of Transforming Growth Factor-β/Smad Signaling

(2012) Chang Joo Oh et al.   PLoS One

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy: FIG. 1.

(2011) Judy B. de Haan   DIABETES

Protective effect of erythropoietin against cisplatin-induced nephrotoxicity in rats: antigenotoxic and antiapoptotic effect

(2011) Karima Rjiba-Touati et al.   DRUG AND CHEMICAL TOXICOLOGY

Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

(2010) T. Jiang et al.   DIABETES

Identification and Characterization of Human UDP-Glucuronosyltransferases Responsible for the In Vitro Glucuronidation of Daphnetin

(2010) S. C. Liang et al.   DRUG METABOLISM AND DISPOSITION

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

(2010) L. M. Aleksunes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice

(2009) Manchang Liu et al.   KIDNEY INTERNATIONAL

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice

(2008) Keigyou Yoh et al.   GENES TO CELLS

TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity

(2008) B. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

Evaluation of Renoprotective Effect ofAphanizomenon flos-aquaeon Cisplatin-Induced Renal Dysfunction in Rats

(2008) Gini C. Kuriakose et al.   RENAL FAILURE