Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation

SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ

(2021) Danish Khan et al.   Cell Reports

Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis

(2020) Linyuan Peng et al.   NUCLEIC ACIDS RESEARCH

Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells

(2020) Xiangli Bai et al.   Oxidative Medicine and Cellular Longevity

Advances in biological therapies for dyslipidemias and atherosclerosis

(2020) Eftaxia-Konstantina Valanti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy

(2019) Penghua Yang et al.   Nature Communications

Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling

(2019) Jian Guo et al.   CIRCULATION RESEARCH

Significance and Mechanistic Relevance of SIRT6-Mediated Endothelial Dysfunction in Cardiovascular Disease Progression

(2019) Gautham Yepuri et al.   CIRCULATION RESEARCH

Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation

(2019) Cristina M. Ramírez et al.   CIRCULATION

CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis

(2019) Xiangli Bai et al.   Autophagy

Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin

(2019) Li Li Han et al.   MOLECULAR CANCER RESEARCH

Differential Epigenetic Factors in the Prediction of Cardiovascular Risk in Diabetic Patients

(2019) Claudio Napoli et al.   European Heart Journal-Cardiovascular Pharmacotherapy

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

(2019) Shoshana Naiman et al.   Cell Reports

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition

(2017) Jiangping He et al.   FEBS Journal

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop

(2017) Xiang-Li Bai et al.   Oncotarget

Caveolin-1/-3: therapeutic targets for myocardial ischemia/reperfusion injury

(2016) Yang Yang et al.   BASIC RESEARCH IN CARDIOLOGY

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

(2016) Jan R. Kraehling et al.   Nature Communications

Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway

(2016) Mi-Young Song et al.   Scientific Reports

Post-translational modifications of the cardiac proteome in diabetes and heart failure

(2015) Adam R. Wende   Proteomics Clinical Applications

C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells

(2014) Fang Bian et al.   BRITISH JOURNAL OF PHARMACOLOGY

Islet-1 Is Essential for Pancreatic  -Cell Function

(2014) B. N. Ediger et al.   DIABETES

Protein post-translational modifications and regulation of pluripotency in human stem cells

(2013) Yu-Chieh Wang et al.   CELL RESEARCH

Fitness, Fatness, and Survival in Adults With Prediabetes

(2013) P. A. McAuley et al.   DIABETES CARE

Ubiquitination of the N-terminal Region of Caveolin-1 Regulates Endosomal Sorting by the VCP/p97 AAA-ATPase

(2013) Philipp Kirchner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role of ADAMTS-5 Protein in Proteoglycan Turnover and Lipoprotein Retention in Atherosclerosis

(2012) Athanasios Didangelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Passage of low-density lipoproteins through Bruch’s membrane and choroid

(2011) Zdravka Cankova et al.   EXPERIMENTAL EYE RESEARCH

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis

(2011) P. Fogelstrand et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Selective Reduction in the Sphingomyelin Content of Atherogenic Lipoproteins Inhibits Their Retention in Murine Aortas and the Subsequent Development of Atherosclerosis

(2010) Yifan Fan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Activation of the ROCK1 Branch of the Transforming Growth Factor-β Pathway Contributes to RAGE-Dependent Acceleration of Atherosclerosis in Diabetic ApoE-Null Mice

(2010) De-xiu Bu et al.   CIRCULATION RESEARCH

Chromatin regulation and genome maintenance by mammalian SIRT6

(2010) Ruth I. Tennen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Postprandial lipemia: An under-recognized atherogenic factor in patients with diabetes mellitus

(2007) Socrates Pastromas et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY