Polydatin enhances glomerular podocyte autophagy homeostasis by improving Nrf2-dependent antioxidant capacity in fructose-fed rats

Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

(2020) Youguang Gao et al.   Journal of Translational Medicine

18α-Glycyrrhetinic acid (GA) ameliorates fructose-induced nephropathy in mice by suppressing oxidative stress, dyslipidemia and inflammation

(2020) Xiaoli Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Autophagy in Chronic Kidney Diseases

(2019) Tien-An Lin et al.   Cells

Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Randomized Controlled Trial

(2019) Li-Jun Liu et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux

(2019) Xiaoting Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

High fructose diet induces early mortality via autophagy factors accumulation in the rostral ventrolateral medulla as ameliorated by pioglitazone

(2019) I Chun Lin et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B

(2019) Xiuwen Zhai et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions

(2019) Di Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation

(2018) Yujie Qiao et al.   TOXICOLOGY LETTERS

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

(2018) Xiao-Juan Zhao et al.   Redox Biology

Brain Nrf2 pathway, autophagy, and synaptic function proteins are modulated by a short-term fructose feeding in young and adult rats

(2018) Maria Stefania Spagnuolo et al.   NUTRITIONAL NEUROSCIENCE

Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes

(2017) Yingli Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys

(2017) Wenyan Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis

(2017) Haitao Shen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Polydatin impairs mitochondria fitness and ameliorates podocyte injury by suppressing Drp1 expression

(2017) Zheng Ni et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fructose downregulates miR-330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin

(2017) Ting-Ting Gu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway

(2017) Lvyi Chen et al.   Food & Function

Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux

(2016) Y. Ling et al.   CLINICAL SCIENCE

Dietary (–)-epicatechin mitigates oxidative stress, NO metabolism alterations, and inflammation in renal cortex from fructose-fed rats

(2016) Paula D. Prince et al.   FREE RADICAL BIOLOGY AND MEDICINE

Podocyte injury and its consequences

(2016) Michio Nagata   KIDNEY INTERNATIONAL

The putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatment

(2016) Qing-Yu Zhang et al.   Oncotarget

Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies

(2016) Steve Duleh et al.   Acta Neuropathologica Communications

Polydatin Inhibits Mitochondrial Dysfunction in the Renal Tubular Epithelial Cells of a Rat Model of Sepsis-Induced Acute Kidney Injury

(2015) Youguang Gao et al.   ANESTHESIA AND ANALGESIA

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377

(2015) Wei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

(2015) Kaipeng Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Curcumin protects against fructose-induced podocyte insulin signaling impairment through upregulation of miR-206

(2015) Xiao-Qin Ding et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Comparative studies of polydatin and resveratrol on mutual transformation and antioxidative effect in vivo

(2015) Hui-Lin Wang et al.   PHYTOMEDICINE

Emerging Liver–Kidney Interactions in Nonalcoholic Fatty Liver Disease

(2015) Giovanni Musso et al.   TRENDS IN MOLECULAR MEDICINE

Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma

(2014) M Corazzari et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Dietary sodium restriction prevents kidney damage in high fructose-fed rats

(2013) Carole Oudot et al.   KIDNEY INTERNATIONAL

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice

(2012) Lvyi Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

(2012) Farhat V.N. Din et al.   GASTROENTEROLOGY

Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy

(2012) E. Jennifer Weil et al.   KIDNEY INTERNATIONAL

Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c

(2012) JINGMING ZHANG et al.   Molecular Medicine Reports

Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice

(2012) Yun-Wei Shi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats

(2012) Pankaj K. Bagul et al.   PHARMACOLOGICAL RESEARCH

Inhibition of mTOR Kinase by AZD8055 Can Antagonize Chemotherapy-induced Cell Death through Autophagy Induction and Down-regulation of p62/Sequestosome 1

(2011) Shengbing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

(2011) Kimberley M. Mellor et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of MTOR Disrupts Autophagic Flux in Podocytes

(2011) D. P. Cina et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The podocyte as a target for therapies—new and old

(2011) Peter W. Mathieson   Nature Reviews Nephrology

Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

(2010) X. Xu et al.   DIABETES

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?

(2009) Richard J. Johnson et al.   ENDOCRINE REVIEWS