Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
Authors
Keywords
-
Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-09-30
DOI
10.1038/s41580-022-00534-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
- (2022) Takayuki Nojima et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Mediator complex as a master regulator of transcription by RNA polymerase II
- (2022) William F. Richter et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Integrator is a genome-wide attenuator of non-productive transcription
- (2021) Søren Lykke-Andersen et al. MOLECULAR CELL
- Hyperosmotic stress alters the RNA polymerase II interactome and induces readthrough transcription despite widespread transcriptional repression
- (2021) Nicolle A. Rosa-Mercado et al. MOLECULAR CELL
- Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator
- (2021) Aishwarya Gurumurthy et al. NUCLEIC ACIDS RESEARCH
- The RNA polymerase II subunit RPB‐9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription
- (2021) Ahmet C Berkyurek et al. EMBO JOURNAL
- Structure of the catalytic core of the Integrator complex
- (2021) Moritz M. Pfleiderer et al. MOLECULAR CELL
- Structure of the human Mediator-bound transcription preinitiation complex
- (2021) R. Abdella et al. SCIENCE
- Disruption of pathways regulated by Integrator complex in Galloway–Mowat syndrome due to WDR73 mutations
- (2021) F. C. Tilley et al. Scientific Reports
- The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
- (2021) Stephin J. Vervoort et al. CELL
- Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets
- (2021) Giacomo Cossa et al. GENES & DEVELOPMENT
- Structure of the human Mediator–RNA polymerase II pre-initiation complex
- (2021) Srinivasan Rengachari et al. NATURE
- NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis
- (2021) Elena Shersher et al. Cell Communication and Signaling
- SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
- (2021) Shibin Hu et al. MOLECULAR CELL
- INTS11 regulates hematopoiesis by promoting PRC2 function
- (2021) Peng Zhang et al. Science Advances
- Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair
- (2021) Yu Jia et al. Cell Discovery
- Structural basis of Integrator-mediated transcription regulation
- (2021) Isaac Fianu et al. SCIENCE
- Integrator enforces the fidelity of transcriptional termination at protein-coding genes
- (2021) Lucas Ferreira Dasilva et al. Science Advances
- Structure of an active human histone pre-mRNA 3′-end processing machinery
- (2020) Yadong Sun et al. SCIENCE
- Evaluating Enhancer Function and Transcription
- (2020) Andrew Field et al. Annual Review of Biochemistry
- Selective PP2A Enhancement through Biased Heterotrimer Stabilization
- (2020) Daniel Leonard et al. CELL
- The integrator complex subunit 11 is involved in the post-diapaused embryonic development and stress response of Artemia sinica
- (2020) Huifang Huang et al. GENE
- Structure and mechanism of the RNA polymerase II transcription machinery
- (2020) Allison C. Schier et al. GENES & DEVELOPMENT
- TFIID Enables RNA Polymerase II Promoter-Proximal Pausing
- (2020) Charli B. Fant et al. MOLECULAR CELL
- NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release
- (2020) Yuki Aoi et al. MOLECULAR CELL
- The SWI/SNF complex in cancer — biology, biomarkers and therapy
- (2020) Priya Mittal et al. Nature Reviews Clinical Oncology
- Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors
- (2020) Pabitra K. Parua et al. Nature Chemical Biology
- INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module
- (2020) Kevin Sabath et al. Nature Communications
- The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts
- (2020) Felipe Beckedorff et al. Cell Reports
- Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1
- (2020) Jasmine Barra et al. Science Advances
- Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination
- (2020) Kai-Lieh Huang et al. MOLECULAR CELL
- Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
- (2020) Pabitra K. Parua et al. Nature Communications
- Integrator is recruited to promoter‐proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors
- (2020) Toni Beltran et al. EMBO JOURNAL
- Structural basis for multifunctional roles of human Ints3 C-terminal domain
- (2020) Jian Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gene regulation by long non-coding RNAs and its biological functions
- (2020) Luisa Statello et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
- (2020) Hai Zheng et al. SCIENCE
- Biallelic sequence variants in INTS1 in patients with developmental delays, cataracts, and craniofacial anomalies
- (2019) Max Krall et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- INTS8 accelerates the epithelial-to-mesenchymal transition in hepatocellular carcinoma by upregulating the TGF-β signaling pathway
- (2019) Hui Tong et al. Cancer Management and Research
- Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes
- (2019) Eva Gómez-Orte et al. PLoS Genetics
- Integrator is a key component of human telomerase RNA biogenesis
- (2019) M. P. Rubtsova et al. Scientific Reports
- Telomeres and telomerase: three decades of progress
- (2019) Jerry W. Shay et al. NATURE REVIEWS GENETICS
- Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination
- (2019) Kinga Kamieniarz-Gdula et al. MOLECULAR CELL
- The highly recurrent PP2A Aα-subunit mutation P179R alters protein structure and impairs PP2A enzyme function to promote endometrial tumorigenesis
- (2019) Sarah E Taylor et al. CANCER RESEARCH
- Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation
- (2019) Leighton Core et al. GENES & DEVELOPMENT
- Long-range enhancer–promoter contacts in gene expression control
- (2019) Stefan Schoenfelder et al. NATURE REVIEWS GENETICS
- The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells
- (2019) Yingjie Zhang et al. Cell Reports
- RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress
- (2019) Cheng-Wei Wu et al. BMC BIOLOGY
- The Integrator complex cleaves nascent mRNAs to attenuate transcription
- (2019) Deirdre C. Tatomer et al. GENES & DEVELOPMENT
- Biallelic INTS1 Mutations Cause a Rare Neurodevelopmental Disorder in Two Chinese Siblings
- (2019) Xuemin Zhang et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors
- (2019) Caitlin M. O’Connor et al. ONCOGENE
- Transcriptional Control by Premature Termination: A Forgotten Mechanism
- (2019) Kinga Kamieniarz-Gdula et al. TRENDS IN GENETICS
- A De Novo Variant Identified in the PPP2R1A Gene in an Infant Induces Neurodevelopmental Abnormalities
- (2019) Yanghui Zhang et al. Neuroscience Bulletin
- Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis
- (2019) Akihide Yoshimi et al. NATURE
- RNA Splicing by the Spliceosome
- (2019) Max E. Wilkinson et al. Annual Review of Biochemistry
- The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes
- (2019) Nathan D. Elrod et al. MOLECULAR CELL
- Targeted Enhancer Activation by a Subunit of the Integrator Complex
- (2018) Elisa Barbieri et al. MOLECULAR CELL
- Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module
- (2018) Todd R Albrecht et al. NUCLEIC ACIDS RESEARCH
- A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II
- (2018) Pabitra K. Parua et al. NATURE
- Structure of paused transcription complex Pol II–DSIF–NELF
- (2018) Seychelle M. Vos et al. NATURE
- Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
- (2018) Seychelle M. Vos et al. NATURE
- Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence
- (2018) Takayuki Nojima et al. MOLECULAR CELL
- PIWI-interacting RNAs: small RNAs with big functions
- (2018) Deniz M. Ozata et al. NATURE REVIEWS GENETICS
- Replication protein A, the laxative that keeps DNA regular: The importance of RPA phosphorylation in maintaining genome stability
- (2018) Brendan M. Byrne et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea
- (2018) David Schmidt et al. PLoS Genetics
- Production of Spliced Long Noncoding RNAs Specifies Regions with Increased Enhancer Activity
- (2018) Noa Gil et al. Cell Systems
- Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs
- (2017) Jingyin Yue et al. GENES & DEVELOPMENT
- Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex
- (2017) Antonio Federico et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
- (2017) Kevin M. Harlen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration
- (2017) Debbie L.C. van den Berg et al. NEURON
- Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome
- (2017) Kyle A. Nilson et al. NUCLEIC ACIDS RESEARCH
- Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance
- (2017) Yixuan Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PAF1 regulation of promoter-proximal pause release via enhancer activation
- (2017) Fei Xavier Chen et al. SCIENCE
- Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications
- (2017) Christopher C. Ebmeier et al. Cell Reports
- Dynamics of RNA Polymerase II Pausing and Bivalent Histone H3 Methylation during Neuronal Differentiation in Brain Development
- (2017) Jiancheng Liu et al. Cell Reports
- Regulation of expression of human RNA polymerase II-transcribed snRNA genes
- (2017) Joana Guiro et al. Open Biology
- Human mutations in integrator complex subunits link transcriptome integrity to brain development
- (2017) Renske Oegema et al. PLoS Genetics
- Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth
- (2016) Dorien Haesen et al. CANCER RESEARCH
- The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain
- (2016) Célia Jeronimo et al. JOURNAL OF MOLECULAR BIOLOGY
- Heptad-Specific Phosphorylation of RNA Polymerase II CTD
- (2016) Roland Schüller et al. MOLECULAR CELL
- Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution
- (2016) M Ryan Corces et al. NATURE GENETICS
- snRNA 3′ End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis
- (2016) Yunfeng Liu et al. PLOS BIOLOGY
- Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution
- (2016) Jimmy Van den Eynden et al. PLoS Genetics
- Reengineered tricyclic anti-cancer agents
- (2015) David B. Kastrinsky et al. BIOORGANIC & MEDICINAL CHEMISTRY
- PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II
- (2015) Fei Xavier Chen et al. CELL
- The Integrator complex controls the termination of transcription at diverse classes of gene targets
- (2015) Jeffrey R Skaar et al. CELL RESEARCH
- The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3′ ends
- (2015) Mingyi Xie et al. GENES & DEVELOPMENT
- B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability
- (2015) Gunnar Houge et al. JOURNAL OF CLINICAL INVESTIGATION
- Architecture of the RNA polymerase II–Mediator core initiation complex
- (2015) C. Plaschka et al. NATURE
- Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
- (2015) Rene C. Adam et al. NATURE
- Integrator mediates the biogenesis of enhancer RNAs
- (2015) Fan Lai et al. NATURE
- The selection and function of cell type-specific enhancers
- (2015) Sven Heinz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
- (2015) Erik Arner et al. SCIENCE
- Bioinformatics analysis of gene expression profiles in childhood B-precursor acute lymphoblastic leukemia
- (2015) Jun Li et al. Hematology
- RNA polymerase II pausing during development
- (2014) B. Gaertner et al. DEVELOPMENT
- Integrator Regulates Transcriptional Initiation and Pause Release following Activation
- (2014) Alessandro Gardini et al. MOLECULAR CELL
- An atlas of active enhancers across human cell types and tissues
- (2014) Robin Andersson et al. NATURE
- Large-scale discovery of novel genetic causes of developmental disorders
- (2014) T. W. Fitzgerald et al. NATURE
- Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes
- (2014) Bernd Stadelmayer et al. Nature Communications
- DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes
- (2014) Junichi Yamamoto et al. Nature Communications
- Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA
- (2014) Wendan Ren et al. Cell Reports
- Control of Transcriptional Elongation
- (2013) Hojoong Kwak et al. Annual Review of Genetics
- Integrator complex plays an essential role in adipose differentiation
- (2013) Yuichiro Otani et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
- (2013) Parthasarathy Seshacharyulu et al. CANCER LETTERS
- HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia
- (2013) Matthew D. Galbraith et al. CELL
- Meeting report - TGF- superfamily: signaling in development and disease
- (2013) Y. E. Zhang et al. JOURNAL OF CELL SCIENCE
- PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
- (2013) Paolo Neviani et al. JOURNAL OF CLINICAL INVESTIGATION
- Protein phosphatase 2A: a target for anticancer therapy
- (2013) Danilo Perrotti et al. LANCET ONCOLOGY
- Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the Integrator complex
- (2013) Jeanne N. Jodoin et al. MOLECULAR BIOLOGY OF THE CELL
- Kinetic Competition between Elongation Rate and Binding of NELF Controls Promoter-Proximal Pausing
- (2013) Jian Li et al. MOLECULAR CELL
- Signaling Pathways Differentially Affect RNA Polymerase II Initiation, Pausing, and Elongation Rate in Cells
- (2013) Charles G. Danko et al. MOLECULAR CELL
- The Genetic Makeup of the Drosophila piRNA Pathway
- (2013) Dominik Handler et al. MOLECULAR CELL
- A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA Pathway
- (2013) Benjamin Czech et al. MOLECULAR CELL
- Human snRNA genes use polyadenylation factors to promote efficient transcription termination
- (2013) Dawn O’Reilly et al. NUCLEIC ACIDS RESEARCH
- The Integrator Complex Subunit 6 (Ints6) Confines the Dorsal Organizer in Vertebrate Embryogenesis
- (2013) Lee D. Kapp et al. PLoS Genetics
- The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms
- (2013) J. N. Jodoin et al. Biology Open
- Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles
- (2012) Takao Naganuma et al. EMBO JOURNAL
- The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity
- (2012) Ward Sents et al. FEBS Journal
- The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders
- (2012) Claire Bacon et al. HUMAN GENETICS
- Requirement for SNAPC1 in Transcriptional Responsiveness to Diverse Extracellular Signals
- (2012) D. Baillat et al. MOLECULAR AND CELLULAR BIOLOGY
- Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
- (2012) Karen Adelman et al. NATURE REVIEWS GENETICS
- The super elongation complex (SEC) family in transcriptional control
- (2012) Zhuojuan Luo et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation
- (2012) J. Chen et al. RNA
- Defining the Status of RNA Polymerase at Promoters
- (2012) Leighton J. Core et al. Cell Reports
- Somatic Mutations of PPP2R1A in Ovarian and Uterine Carcinomas
- (2011) Ie-Ming Shih et al. AMERICAN JOURNAL OF PATHOLOGY
- Prognostic role of CIP2A expression in serous ovarian cancer
- (2011) C Böckelman et al. BRITISH JOURNAL OF CANCER
- Analysis of the Human Endogenous Coregulator Complexome
- (2011) Anna Malovannaya et al. CELL
- A Primate Herpesvirus Uses the Integrator Complex to Generate Viral MicroRNAs
- (2011) Demián Cazalla et al. MOLECULAR CELL
- Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters
- (2011) Frederic Koch et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
- (2011) Derek J. Richard et al. NUCLEIC ACIDS RESEARCH
- c-Myc Regulates Transcriptional Pause Release
- (2010) Peter B. Rahl et al. CELL
- The Integrator Complex Recognizes a New Double Mark on the RNA Polymerase II Carboxyl-terminal Domain
- (2010) Sylvain Egloff et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation
- (2010) N. Ezzeddine et al. MOLECULAR AND CELLULAR BIOLOGY
- Widespread transcription at neuronal activity-regulated enhancers
- (2010) Tae-Kyung Kim et al. NATURE
- hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
- (2010) Derek J. Richard et al. NUCLEIC ACIDS RESEARCH
- Streamlined analysis schema for high-throughput identification of endogenous protein complexes
- (2010) A. Malovannaya et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Close association of RNA polymerase II and many transcription factors with Pol III genes
- (2010) Debasish Raha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers
- (2010) Francesca De Santa et al. PLOS BIOLOGY
- INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling
- (2009) Stephanie Filleur et al. Cancer Cell International
- The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling
- (2009) S. Tao et al. DEVELOPMENT
- hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response
- (2009) Yongjiang Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- INTS3 controls the hSSB1-mediated DNA damage response
- (2009) Jeffrey R. Skaar et al. JOURNAL OF CELL BIOLOGY
- SOSS Complexes Participate in the Maintenance of Genomic Stability
- (2009) Jun Huang et al. MOLECULAR CELL
- An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles
- (2009) Christine M. Clemson et al. MOLECULAR CELL
- Expression of human snRNA genes from beginning to end
- (2008) Sylvain Egloff et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
- (2008) Derek J. Richard et al. NATURE
- Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II
- (2008) L. J. Core et al. SCIENCE
- Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
- (2008) Leighton J. Core et al. SCIENCE
- CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma
- (2007) Yoshikazu Inagaki et al. CANCER GENETICS AND CYTOGENETICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now