Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex

Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression

(2017) William Poole et al.   PLoS Computational Biology

Integrator complex and transcription regulation: Recent findings and pathophysiology

(2016) Monica Rienzo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes

(2016) R. Guerrero-Preston et al.   Cancer Prevention Research

Evaluating the evaluation of cancer driver genes

(2016) Collin J. Tokheim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites

(2016) Byungho Lim et al.   Oncotarget

The Integrator complex controls the termination of transcription at diverse classes of gene targets

(2015) Jeffrey R Skaar et al.   CELL RESEARCH

‘Latent drivers’ expand the cancer mutational landscape

(2015) Ruth Nussinov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Integrator mediates the biogenesis of enhancer RNAs

(2015) Fan Lai et al.   NATURE

Integrator: surprisingly diverse functions in gene expression

(2015) David Baillat et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma

(2015) Haoran Peng et al.   Oncotarget

New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma

(2015) Valerio Costa et al.   Oncotarget

Bioinformatics analysis of gene expression profiles in childhood B-precursor acute lymphoblastic leukemia

(2015) Jun Li et al.   Hematology

Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma

(2015) Haley M. Simpson et al.   PLoS One

Integrator Regulates Transcriptional Initiation and Pause Release following Activation

(2014) Alessandro Gardini et al.   MOLECULAR CELL

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

(2014) Mark D M Leiserson et al.   NATURE GENETICS

Cancer genomes: discerning drivers from passengers

(2014) Vivien Marx   NATURE METHODS

Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes

(2014) Bernd Stadelmayer et al.   Nature Communications

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients

(2013) Lei Cheng et al.   GENOMICS

A core hSSB1-INTS complex participates in the DNA damage response

(2013) F. Zhang et al.   JOURNAL OF CELL SCIENCE

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Human snRNA genes use polyadenylation factors to promote efficient transcription termination

(2013) Dawn O’Reilly et al.   NUCLEIC ACIDS RESEARCH

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

snRNA 3' End Formation Requires Heterodimeric Association of Integrator Subunits

(2012) T. R. Albrecht et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia

(2011) E Ellinghaus et al.   LEUKEMIA

Massive-Scale RNA-Seq Analysis of Non Ribosomal Transcriptome in Human Trisomy 21

(2011) Valerio Costa et al.   PLoS One

A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

(2011) C. Cotta-Ramusino et al.   SCIENCE

snRNA 3′ end formation: the dawn of the Integrator complex

(2010) Jiandong Chen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation

(2010) N. Ezzeddine et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrator3, a Partner of Single-stranded DNA-binding Protein 1, Participates in the DNA Damage Response

(2009) Feng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response

(2009) Yongjiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

INTS3 controls the hSSB1-mediated DNA damage response

(2009) Jeffrey R. Skaar et al.   JOURNAL OF CELL BIOLOGY

Expression profiles of SV40-immortalization-associated genes upregulated in various human cancers

(2009) Hyun Min Jung et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SOSS Complexes Participate in the Maintenance of Genomic Stability

(2009) Jun Huang et al.   MOLECULAR CELL

CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma

(2007) Yoshikazu Inagaki et al.   CANCER GENETICS AND CYTOGENETICS