A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA

New chemistries and enzymes for synthetic genetics

(2021) Niklas Freund et al.   CURRENT OPINION IN BIOTECHNOLOGY

The 10th Oligonucleotide Therapy Approved: Golodirsen for Duchenne Muscular Dystrophy

(2020) Annemieke Aartsma-Rus et al.   Nucleic Acid Therapeutics

Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity

(2020) Gillian Houlihan et al.   Nature Chemistry

Diversity and evolution of B-family DNA polymerases

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DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences

(2020) Hidekazu Hoshino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA 2’-O-Methylation (Nm) Modification in Human Diseases

(2019) Dilyana G. Dimitrova et al.   Genes

Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics

(2019) Alexander I. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

(2018) Hannes Mutschler et al.   eLife

Nm-seq maps 2′-O-methylation sites in human mRNA with base precision

(2017) Qing Dai et al.   NATURE METHODS

Crystal structures of ternary complexes of archaeal B-family DNA polymerases

(2017) Heike M. Kropp et al.   PLoS One

Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers

(2017) Zhixia Liu et al.   Chemical Science

Primer-Independent DNA Synthesis by a Family B DNA Polymerase from Self-Replicating Mobile Genetic Elements

(2017) Modesto Redrejo-Rodríguez et al.   Cell Reports

The Medicinal Chemistry of Therapeutic Oligonucleotides

(2016) W. Brad Wan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evolution of thermophilic DNA polymerases for the recognition and amplification of C2ʹ-modified DNA

(2016) Tingjian Chen et al.   Nature Chemistry

Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′-5′ Linkages

(2015) Christopher Cozens et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directed evolution of artificial enzymes (XNAzymes) from diverse repertoires of synthetic genetic polymers

(2015) Alexander I Taylor et al.   Nature Protocols

Transcription yield of fully 2′-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

(2015) Adam J. Meyer et al.   NUCLEIC ACIDS RESEARCH

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

DNA polymerases drive DNA sequencing-by-synthesis technologies: both past and present

(2014) Cheng-Yao Chen   Frontiers in Microbiology

NMR structure of 2′-O-(2-methoxyethyl) modified and C5-methylated RNA dodecamer duplex

(2013) Miha Plevnik et al.   BIOCHIMIE

Identification of a T7 RNA polymerase variant that permits the enzymatic synthesis of fully 2′-O-methyl-modified RNA

(2013) Jenny Ibach et al.   JOURNAL OF BIOTECHNOLOGY

Mechanism for priming DNA synthesis by yeast DNA Polymerase α

(2013) Rajika L Perera et al.   eLife

Structural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and Ribonucleotides

(2012) Weina Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A short adaptive path from DNA to RNA polymerases

(2012) C. Cozens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

The Structure of a High Fidelity DNA Polymerase Bound to a Mismatched Nucleotide Reveals an “Ajar” Intermediate Conformation in the Nucleotide Selection Mechanism

(2011) Eugene Y. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

An Improved One-Pot Synthesis of Nucleoside 5′-Triphosphate Analogues

(2010) Irina Gillerman et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Biophysical characterization of DNA aptamer interactions with vascular endothelial growth factor

(2008) Ajish S. R. Potty et al.   BIOPOLYMERS