TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch

RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA

(2022) Nicole Kaminski et al.   MOLECULAR CELL

PIF1 helicase promotes break‐induced replication in mammalian cells

(2021) Shibo Li et al.   EMBO JOURNAL

Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies

(2021) Jia-Min Zhang et al.   MOLECULAR CELL

A unified alternative telomere-lengthening pathway in yeast survivor cells

(2021) Zachary W. Kockler et al.   MOLECULAR CELL

RNA transcripts stimulate homologous recombination by forming DR-loops

(2021) Jian Ouyang et al.   NATURE

R-loops as Janus-faced modulators of DNA repair

(2021) Aline Marnef et al.   NATURE CELL BIOLOGY

The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells

(2021) Antoine Simoneau et al.   GENES & DEVELOPMENT

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

(2021) Bruno Silva et al.   Nature Communications

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

(2021) Jekaterina Vohhodina et al.   Nature Communications

The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

(2021) Charanya Kumar et al.   eLife

Break-induced replication mechanisms in yeast and mammals

(2021) Xiaohua Wu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mechanisms that drive telomere maintenance and recombination in human cancers

(2020) Alexander P Sobinoff et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Resolution of ROS‐induced G‐quadruplexes and R‐loops at transcriptionally active sites is dependent on BLM helicase

(2020) Jun Tan et al.   FEBS LETTERS

Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks

(2020) Jia-Min Zhang et al.   Cell and Bioscience

qDRIP: a method to quantitatively assess RNA–DNA hybrid formation genome-wide

(2020) Magdalena P Crossley et al.   NUCLEIC ACIDS RESEARCH

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

(2020) Marianna Feretzaki et al.   NATURE

RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

(2020) Panagiotis Kotsantis et al.   Cell Reports

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

(2019) Jia-Min Zhang et al.   Cell Reports

RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening

(2019) Priyanka Verma et al.   GENES & DEVELOPMENT

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

(2019) Jaewon Min et al.   GENES & DEVELOPMENT

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

(2019) Robert Lu et al.   Nature Communications

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

(2019) Bruno Silva et al.   Nature Communications

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

(2019) Agnese Cristini et al.   Cell Reports

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

(2019) Jonathan Barroso-González et al.   MOLECULAR CELL

ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

(2019) Dominick A. Matos et al.   MOLECULAR CELL

Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

(2019) Nagaraja Chappidi et al.   MOLECULAR CELL

An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks

(2019) Jun Tan et al.   NUCLEIC ACIDS RESEARCH

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops

(2019) Xiaolei Pan et al.   Scientific Reports

How RNA transcripts coordinate DNA recombination and repair

(2018) Shane McDevitt et al.   Nature Communications

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism

(2018) Özgün Özer et al.   Oncotarget

Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

(2018) Takaaki Yasuhara et al.   CELL

ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB

(2018) Yaqun Teng et al.   Nature Communications

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair

(2017) Olga M. Mazina et al.   MOLECULAR CELL

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

(2017) Flavia Michelini et al.   NATURE CELL BIOLOGY

Alternative lengthening of human telomeres is a conservative DNA replication process with features of break‐induced replication

(2016) Fani‐Marlen Roumelioti et al.   EMBO REPORTS

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

(2016) Sotirios K. Sotiriou et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

(2016) Laura Garcia-Exposito et al.   Cell Reports

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

(2015) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

Transcript-RNA-templated DNA recombination and repair

(2014) Havva Keskin et al.   NATURE

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase

(2014) Tai-Yuan Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

(2013) Marenda A. Wilson et al.   NATURE

Migrating bubble during break-induced replication drives conservative DNA synthesis

(2013) Natalie Saini et al.   NATURE

Mechanistic Insights into RAD51-associated Protein 1 (RAD51AP1) Action in Homologous DNA Repair

(2012) Myun Hwa Dunlop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer and Telomeres--An ALTernative to Telomerase

(2012) J. W. Shay et al.   SCIENCE

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY