Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks

Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination

(2019) Tianpeng Zhang et al.   PLoS Genetics

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

(2019) Jia-Min Zhang et al.   Cell Reports

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

(2019) Eleonora Petti et al.   Nature Communications

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

(2019) Yuxiang Wang et al.   Nature Communications

Telomeres and telomerase: three decades of progress

(2019) Jerry W. Shay et al.   NATURE REVIEWS GENETICS

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

(2019) Sefan Asamitsu et al.   MOLECULES

Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency

(2019) Mingqi Han et al.   JOURNAL OF CELL SCIENCE

RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening

(2019) Priyanka Verma et al.   GENES & DEVELOPMENT

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

(2019) Jaewon Min et al.   GENES & DEVELOPMENT

TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1

(2019) Harikleia Episkopou et al.   MOLECULAR CELL

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

(2019) Robert Lu et al.   Nature Communications

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

(2019) Bruno Silva et al.   Nature Communications

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

(2019) Stephanie Panier et al.   MOLECULAR CELL

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

(2019) Jonathan Barroso-González et al.   MOLECULAR CELL

An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks

(2019) Jun Tan et al.   NUCLEIC ACIDS RESEARCH

Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway

(2019) Mafei Xu et al.   Science Advances

Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT)

(2018) Marco De Vitis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Telomeres: Implications for Cancer Development

(2018) Aina Bernal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination

(2018) Szilvia Juhász et al.   MOLECULAR CELL

Break-Induced Replication: The Where, The Why, and The How

(2018) J. Kramara et al.   TRENDS IN GENETICS

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism

(2018) Özgün Özer et al.   Oncotarget

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic analysis of telomere length and somatic alterations in 31 cancer types

(2017) Floris P Barthel et al.   NATURE GENETICS

FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

(2017) Xiaolei Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge

(2017) Alexander P. Sobinoff et al.   TRENDS IN GENETICS

ATRX and DAXX: Mechanisms and Mutations

(2017) Michael A. Dyer et al.   Cold Spring Harbor Perspectives in Medicine

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Alternative lengthening of human telomeres is a conservative DNA replication process with features of break‐induced replication

(2016) Fani‐Marlen Roumelioti et al.   EMBO REPORTS

FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway

(2016) Heather Root et al.   HUMAN MOLECULAR GENETICS

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

(2016) Sotirios K. Sotiriou et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

SMARCAL1 Resolves Replication Stress at ALT Telomeres

(2016) Kelli E. Cox et al.   Cell Reports

Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers

(2015) Paulina Marzec et al.   CELL

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening

(2015) S. Osterwald et al.   JOURNAL OF CELL SCIENCE

SMARCAL1 maintains telomere integrity during DNA replication

(2015) Lisa A. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

ATRX represses alternative lengthening of telomeres

(2015) Christine E. Napier et al.   Oncotarget

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

(2015) Kasthuri Kannan et al.   Oncotarget

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination

(2014) Dimitri Conomos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

Break-induced replication: functions and molecular mechanism

(2013) Anna Malkova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress

(2013) Justin Wai-Chung Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

Break-Induced DNA Replication

(2013) R. P. Anand et al.   Cold Spring Harbor Perspectives in Biology

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells

(2012) Dimitri Conomos et al.   JOURNAL OF CELL BIOLOGY

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Loss of Atrx Sensitizes Cells to DNA Damaging Agents through p53-Mediated Death Pathways

(2012) Damiano Conte et al.   PLoS One

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

(2010) Carolyn J. McNees et al.   JOURNAL OF CELL BIOLOGY

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Telomeres: protecting chromosomes against genome instability

(2010) Roderick J. O'Sullivan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATR contributes to telomere maintenance in human cells

(2010) Gaëlle Pennarun et al.   NUCLEIC ACIDS RESEARCH

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PML3 interacts with TRF1 and is essential for ALT-associated PML bodies assembly in U2OS cells

(2009) Jian Yu et al.   CANCER LETTERS

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination

(2009) I. Draskovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

(2008) A. Muntoni et al.   HUMAN MOLECULAR GENETICS

Remodeling of DNA replication structures by the branch point translocase FANCM

(2008) K. Gari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA