RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA

TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch

(2022) Tribhuwan Yadav et al.   MOLECULAR CELL

BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2–RAD52

(2021) Elodie Hatchi et al.   NATURE

PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

(2021) Roman M. Chabanon et al.   CANCER RESEARCH

RNA transcripts stimulate homologous recombination by forming DR-loops

(2021) Jian Ouyang et al.   NATURE

R-loops as Janus-faced modulators of DNA repair

(2021) Aline Marnef et al.   NATURE CELL BIOLOGY

The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts

(2021) Aleix Bayona-Feliu et al.   NATURE GENETICS

RTEL1 influences the abundance and localization of TERRA RNA

(2021) Fiorella Ghisays et al.   Nature Communications

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

(2021) Bruno Silva et al.   Nature Communications

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

(2021) Jekaterina Vohhodina et al.   Nature Communications

RNA promotes the formation of spatial compartments in the nucleus

(2021) Sofia A. Quinodoz et al.   CELL

Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

(2021) Jonathan Barroso-González et al.   Cell Reports

Genomic footprints of activated telomere maintenance mechanisms in cancer

(2020) Lina Sieverling et al.   Nature Communications

The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair

(2020) Fengshan Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

(2020) Marianna Feretzaki et al.   NATURE

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

(2020) Song My Hoang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates

(2020) Chaoyou Xue et al.   NUCLEIC ACIDS RESEARCH

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

(2019) Jia-Min Zhang et al.   Cell Reports

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

(2019) Eleonora Petti et al.   Nature Communications

R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes

(2019) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening

(2019) Priyanka Verma et al.   GENES & DEVELOPMENT

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

(2019) Fengshan Liang et al.   Nature Communications

Absolute quantification of cohesin, CTCF and their regulators in human cells

(2019) Johann Holzmann et al.   eLife

ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization

(2019) Fei Li et al.   EMBO JOURNAL

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

(2019) Jae Jin Kim et al.   GENES & DEVELOPMENT

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

(2019) Jonathan Barroso-González et al.   MOLECULAR CELL

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

(2019) Stephanie Panier et al.   MOLECULAR CELL

An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks

(2019) Jun Tan et al.   NUCLEIC ACIDS RESEARCH

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability

(2018) Cornelia Meisenberg et al.   MOLECULAR CELL

Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair

(2017) Fade Gong et al.   JOURNAL OF CELL BIOLOGY

Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care

(2017) Aline Marnef et al.   JOURNAL OF MOLECULAR BIOLOGY

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair

(2017) Olga M. Mazina et al.   MOLECULAR CELL

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair

(2017) Enas R Abu-Zhayia et al.   Journal of Molecular Cell Biology

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sororin actively maintains sister chromatid cohesion

(2016) Rene Ladurner et al.   EMBO JOURNAL

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

(2016) Martijn S. Luijsterburg et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex

(2016) Fengshan Liang et al.   Cell Reports

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

(2016) Laura Garcia-Exposito et al.   Cell Reports

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

(2015) Fade Gong et al.   GENES & DEVELOPMENT

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

TRF1 and TRF2 Differentially Modulate Rad51-Mediated Telomeric and Nontelomeric Displacement Loop Formation in Vitro

(2014) Brian D. Bower et al.   BIOCHEMISTRY

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin

(2014) Andreas Kakarougkas et al.   MOLECULAR CELL

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

Transcript-RNA-templated DNA recombination and repair

(2014) Havva Keskin et al.   NATURE

Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription

(2014) Özge Z. Aydin et al.   NUCLEIC ACIDS RESEARCH

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

(2014) Peter M. Brownlee et al.   Cell Reports

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

Mechanistic Insights into RAD51-associated Protein 1 (RAD51AP1) Action in Homologous DNA Repair

(2012) Myun Hwa Dunlop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response

(2012) O. Yuce et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription regulates telomere dynamics in human cancer cells

(2012) R. Arora et al.   RNA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Abacus: A computational tool for extracting and pre-processing spectral count data for label-free quantitative proteomic analysis

(2011) Damian Fermin et al.   PROTEOMICS

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

The ACF1 Complex Is Required for DNA Double-Strand Break Repair in Human Cells

(2010) Li Lan et al.   MOLECULAR CELL

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

(2010) Eloïse Dray et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols