Synovial fibroblast-miR-214-3p-derived exosomes inhibit inflammation and degeneration of cartilage tissues of osteoarthritis rats

Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression

(2021) Yumei Cao et al.   EBioMedicine

The dual character of exosomes in osteoarthritis: Antagonists and therapeutic agents

(2020) Quan-fa Zhou et al.   Acta Biomaterialia

Intra-articular delivery of extracellular vesicles secreted by chondrogenic progenitor cells from MRL/MpJ superhealer mice enhances articular cartilage repair in a mouse injury model

(2020) Rikang Wang et al.   Stem Cell Research & Therapy

Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12

(2019) Selene Pérez‐García et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis

(2019) Agnes Schröder et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoarthritis

(2019) David J Hunter et al.   LANCET

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis

(2019) Zhenhong Ni et al.   Cell Death & Disease

Association between cytokines and exosomes in synovial fluid of individuals with knee osteoarthritis

(2019) Kun Gao et al.   Modern Rheumatology

The potential of exosomes in the therapy of the cartilage and bone complications; emphasis on osteoarthritis

(2019) Ramin Pourakbari et al.   LIFE SCIENCES

Emerging role of extracellular vesicles in musculoskeletal diseases

(2018) Cameron Murphy et al.   MOLECULAR ASPECTS OF MEDICINE

Stability of Circulating Exosomal miRNAs in Healthy Subjects

(2018) David Sanz-Rubio et al.   Scientific Reports

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

(2018) Guping Mao et al.   Stem Cell Research & Therapy

Extracellular Vesicles in Joint Disease and Therapy

(2018) Janneke Boere et al.   Frontiers in Immunology

Characterization of the Proinflammatory Profile of Synovial Fluid-Derived Exosomes of Patients with Osteoarthritis

(2017) Rossana Domenis et al.   MEDIATORS OF INFLAMMATION

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

MicroRNA Profiling in Cartilage Ageing

(2017) Panagiotis Balaskas et al.   International Journal of Genomics

The role of microRNAs in the pathogenesis of autoimmune diseases

(2016) Ji-Qing Chen et al.   AUTOIMMUNITY REVIEWS

Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges

(2016) Maryam Rahmati et al.   BONE

Extracellular vesicles — new tool for joint repair and regeneration

(2016) Jos Malda et al.   Nature Reviews Rheumatology

MicroRNAs: exploring new horizons in osteoarthritis

(2016) M. Nugent   OSTEOARTHRITIS AND CARTILAGE

Synovitis and the risk of knee osteoarthritis: the MOST Study

(2016) D.T. Felson et al.   OSTEOARTHRITIS AND CARTILAGE

Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling

(2015) Yan Zhou et al.   APOPTOSIS

MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4

(2015) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway

(2015) Chenyang Zhao et al.   RNA Biology

Co-culture with human synovium-derived mesenchymal stem cells inhibits inflammatory activity and increases cell proliferation of sodium nitroprusside-stimulated chondrocytes

(2014) Jae-Sung Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes

(2014) Tomohiro Kato et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix

(2013) Kaikai Shi et al.   BONE

Biologic agents in osteoarthritis: hopes and disappointments

(2013) Xavier Chevalier et al.   Nature Reviews Rheumatology

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

miR-214 targets ATF4 to inhibit bone formation

(2012) Xiaogang Wang et al.   NATURE MEDICINE