Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling

Targets, models and challenges in osteoarthritis research

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Metabolic triggered inflammation in osteoarthritis

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Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways

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Resveratrol protects rabbit articular chondrocyte against sodium nitroprusside-induced apoptosis via scavenging ROS

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Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats

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Cell death in human articular chondrocyte: a morpho-functional study in micromass model

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The epidemiology of osteoarthritis

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Co-culture with human synovium-derived mesenchymal stem cells inhibits inflammatory activity and increases cell proliferation of sodium nitroprusside-stimulated chondrocytes

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Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved

(2014) Elisa Nicoloso Simões Pires et al.   BRAIN RESEARCH

Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

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Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy

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Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes

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Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes

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Emerging regulators of the inflammatory process in osteoarthritis

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Neuroprotective and Anti-Apoptotic Propensity of Bacopa monniera Extract Against Sodium Nitroprusside Induced Activation of iNOS, Heat Shock Proteins and Apoptotic Markers in PC12 Cells

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Adiabatic rotating frame relaxation of MRI reveals early cartilage degeneration in a rabbit model of anterior cruciate ligament transection

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Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein

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Sodium nitroprusside, a nitric oxide donor for novel treatment of schizophrenia, may also modulate dopaminergic systems

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Extracorporeal shockwave therapy in osteoporotic osteoarthritis of the knee in rats: an experiment in animals

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The spatial organisation of joint surface chondrocytes: review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis

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The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Characterization of bacterial communities in hybrid upflow anaerobic sludge blanket (UASB)–membrane bioreactor (MBR) process for berberine antibiotic wastewater treatment

(2013) Guanglei Qiu et al.   BIORESOURCE TECHNOLOGY

Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts

(2013) Chi Man Tsang et al.   BMC CANCER

Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: New implications for osteonecrosis treatment?

(2013) Chang She et al.   CELLULAR SIGNALLING

The effect of sodium nitroprusside on cerebral hemodynamics and headache in healthy subjects

(2013) Song Guo et al.   CEPHALALGIA

Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis

(2013) Robert Domitrović et al.   FOOD AND CHEMICAL TOXICOLOGY

A current review of molecular mechanisms regarding osteoarthritis and pain

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Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritisviaAkt signalling

(2013) Honghai Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Static Mechanical Stress Induces Apoptosis in Rat Endplate Chondrocytes through MAPK and Mitochondria-Dependent Caspase Activation Signaling Pathways

(2013) Dechao Kong et al.   PLoS One

C/EBP homologous protein drives pro-catabolic responses in chondrocytes

(2013) Matt Husa et al.   ARTHRITIS RESEARCH & THERAPY

Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism

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Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice

(2011) Fang Yan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Adiponectin is a potential catabolic mediator in osteoarthritis cartilage

(2011) Eun Ha Kang et al.   ARTHRITIS RESEARCH & THERAPY

Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis

(2010) Zhenlin Hu et al.   ARTHRITIS AND RHEUMATISM

Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis

(2010) Dominik R. Haudenschild et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Baekjeolyusin-tang and its active component berberine block the release of collagen and proteoglycan from IL-1β-stimulated rabbit cartilage and down-regulate matrix metalloproteinases in rabbit chondrocytes

(2010) Phil-Dong Moon et al.   PHYTOTHERAPY RESEARCH

Protective Effects of Berberine in an Experimental Rat Osteoarthritis Model

(2010) Peng-fei Hu et al.   PHYTOTHERAPY RESEARCH

Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes

(2010) Zafar Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase

(2009) Yiqun Wang et al.   CARDIOVASCULAR RESEARCH