Ultrastructural characterization of dark microglia during aging in a mouse model of Alzheimer’s disease pathology and in human post-mortem brain samples

Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment

(2022) Elisa Guma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

(2021) Paras S. Minhas et al.   NATURE

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

(2021) Kevin Clayton et al.   Molecular Neurodegeneration

Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior

(2021) Yuki Yasumoto et al.   MOLECULAR PSYCHIATRY

Microglia use TAM receptors to detect and engulf amyloid β plaques

(2021) Youtong Huang et al.   NATURE IMMUNOLOGY

Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

(2021) Melissa K. Edler et al.   Cells

Classification of Microglial Morphological Phenotypes Using Machine Learning

(2021) Judith Leyh et al.   Frontiers in Cellular Neuroscience

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

(2021) Alexandra Grubman et al.   Nature Communications

Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

(2021) Maria I. Alvarez-Vergara et al.   Nature Communications

CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

(2021) Chritica Lodder et al.   Acta Neuropathologica Communications

Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease

(2021) Marie-Victoire Guillot-Sestier et al.   Communications Biology

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis

(2021) Raquel Sanchez-Varo et al.   Frontiers in Neuroscience

Dystrophic microglia in late‐onset Alzheimer's disease

(2020) Wolfgang J. Streit et al.   GLIA

Microglia heterogeneity and neurodegeneration: The emerging paradigm of the role of immunity in Alzheimer's disease

(2020) Arsalan Hashemiaghdam et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology

(2020) Julie C. Savage et al.   Journal of Neuroinflammation

Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies

(2020) Brad T. Casali et al.   NEUROBIOLOGY OF DISEASE

Levodopa partially rescues microglial numerical, morphological, and phagolysosomal alterations in a monkey model of Parkinson’s disease

(2020) Cynthia Lecours et al.   BRAIN BEHAVIOR AND IMMUNITY

A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature

(2020) Erica Mondo et al.   JOURNAL OF NEUROSCIENCE

The age-related microglial transformation in Alzheimer's disease pathogenesis

(2020) Chunxu Yuan et al.   NEUROBIOLOGY OF AGING

Quantitative immunohistochemical analysis of myeloid cell marker expression in human cortex captures microglia heterogeneity with anatomical context

(2020) Molly E. V. Swanson et al.   Scientific Reports

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

(2020) Laura Sebastian Monasor et al.   eLife

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

(2020) Anna Picca et al.   Antioxidants

Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet

(2020) Maude Bordeleau et al.   Journal of Neuroinflammation

Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies

(2020) Ceyhan Ceran Serdar et al.   Biochemia Medica

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

(2019) Allison McIntosh et al.   BRAIN PATHOLOGY

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

(2019) Darshpreet Kaur et al.   INFLAMMOPHARMACOLOGY

Glycogen distribution in mouse hippocampus

(2019) Hajime Hirase et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology

(2019) Hassan El Hajj et al.   Journal of Neuroinflammation

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Intersection of pathological tau and microglia at the synapse

(2019) Thomas Vogels et al.   Acta Neuropathologica Communications

Microglial subtypes: diversity within the microglial community

(2019) Vassilis Stratoulias et al.   EMBO JOURNAL

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

What Do Microglia Really Do in Healthy Adult Brain?

(2019) Marcus Augusto-Oliveira et al.   Cells

IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia

(2019) Fátima Rivera-Escalera et al.   Journal of Neuroinflammation

Microglia-Mediated Neuroprotection, TREM2 , and Alzheimer’s Disease: Evidence From Optical Imaging

(2018) Carlo Condello et al.   BIOLOGICAL PSYCHIATRY

Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome

(2018) Chin Wai Hui et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

(2018) R. Holland et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain Inflammation Connects Cognitive and Non-Cognitive Symptoms in Alzheimer’s Disease

(2018) M. Clara Selles et al.   JOURNAL OF ALZHEIMERS DISEASE

The dynamic life of the glycogen granule

(2018) Clara Prats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

(2018) Justyna Sosna et al.   Molecular Neurodegeneration

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia

(2018) Chin W. Hui et al.   Frontiers in Molecular Neuroscience

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

(2018) Sara E. Nasrabady et al.   Acta Neuropathologica Communications

Reduced microglial activity and enhanced glutamate transmission in the basolateral amygdala in early CNS autoimmunity

(2018) Shaona Acharjee et al.   JOURNAL OF NEUROSCIENCE

CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease

(2018) Ankita K. Shukla et al.   GLIA

Association between Hippocampal Shape, Neuroinflammation, and Cognitive Decline in Alzheimer’s Disease

(2018) Monia Cabinio et al.   JOURNAL OF ALZHEIMERS DISEASE

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

(2017) Angela Gomez-Arboledas et al.   GLIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Old Maids: Aging and Its Impact on Microglia Function

(2017) Edward Koellhoffer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Practical considerations for choosing a mouse model of Alzheimer’s disease

(2017) Joanna L. Jankowsky et al.   Molecular Neurodegeneration

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

(2017) Zhuoran Yin et al.   NEUROBIOLOGY OF AGING

Environmental stimuli shape microglial plasticity in glioma

(2017) Stefano Garofalo et al.   eLife

Brain atrophy in Alzheimer’s Disease and aging

(2016) Lorenzo Pini et al.   AGEING RESEARCH REVIEWS

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Young microglia restore amyloid plaque clearance of aged microglia

(2016) Anna Daria et al.   EMBO JOURNAL

Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous astrocytic patterns

(2016) Yuki Oe et al.   GLIA

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Does age matter? The impact of rodent age on study outcomes

(2016) Samuel J Jackson et al.   LABORATORY ANIMALS

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease

(2016) M. S. Unger et al.   MOLECULAR NEUROBIOLOGY

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Altered motility of plaque-associated microglia in a model of Alzheimer’s disease

(2016) Stefka Gyoneva et al.   NEUROSCIENCE

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques

(2016) Kanchan Bisht et al.   Jove-Journal of Visualized Experiments

Glio-vascular changes during ageing in wild-type and Alzheimer׳s disease-like APP/PS1 mice

(2015) C.S. Janota et al.   BRAIN RESEARCH

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease

(2015) Michael M. Zeineh et al.   NEUROBIOLOGY OF AGING

Microglia in Health and Disease

(2015) Richard M. Ransohoff et al.   Cold Spring Harbor Perspectives in Biology

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease

(2014) Zuzana Šišková et al.   NEURON

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

(2014) Anders M. Fjell et al.   PROGRESS IN NEUROBIOLOGY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Synaptic plasticity in health and disease: introduction and overview

(2013) T. V. P. Bliss et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

(2013) Jean-Philippe Michaud et al.   Cell Reports

Microglia and Synapse: Interactions in Health and Neurodegeneration

(2013) Zuzana Šišková et al.   NEURAL PLASTICITY

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

(2012) Marie-Ève Tremblay et al.   GLIA

Deleterious effects of mitochondrial ROS generated by KillerRed photodynamic action in human cell lines and C. elegans

(2012) Toshiharu Shibuya et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Early microglial colonization of the human forebrain and possible involvement in periventricular white-matter injury of preterm infants

(2010) Catherine Verney et al.   JOURNAL OF ANATOMY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity

(2008) Kryslaine O. Lopes et al.   GLIA