Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology

Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington’s disease-like phenotype in BACHD mice

(2019) Terri L Petkau et al.   HUMAN MOLECULAR GENETICS

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

(2019) Christopher M. Henstridge et al.   Frontiers in Cellular Neuroscience

Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology

(2019) Hassan El Hajj et al.   Journal of Neuroinflammation

A decade of diverse microglial-neuronal physical interactions in the brain (2008–2018)

(2019) Joseph O. Uweru et al.   NEUROSCIENCE LETTERS

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Targeting the Synapse in Alzheimer’s Disease

(2019) Johanna Jackson et al.   Frontiers in Neuroscience

Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome

(2018) Chin Wai Hui et al.   BRAIN BEHAVIOR AND IMMUNITY

Disrupted striatal neuron inputs and outputs in Huntington's disease

(2018) Anton Reiner et al.   CNS Neuroscience & Therapeutics

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

FIB/SEM Technology and Alzheimer's Disease: Three-Dimensional Analysis of Human Cortical Synapses

(2018) Lidia Blazquez-Llorca et al.   JOURNAL OF ALZHEIMERS DISEASE

NeuroMorph: A Software Toolset for 3D Analysis of Neurite Morphology and Connectivity

(2018) Anne Jorstad et al.   Frontiers in Neuroanatomy

VAST (Volume Annotation and Segmentation Tool): Efficient Manual and Semi-Automatic Labeling of Large 3D Image Stacks

(2018) Daniel R. Berger et al.   Frontiers in Neural Circuits

Microglial Activation in the Pathogenesis of Huntington’s Disease

(2017) Hui-Ming Yang et al.   Frontiers in Aging Neuroscience

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

(2016) Anne H.P. Jansen et al.   GLIA

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

(2016) Tuan Leng Tay et al.   JOURNAL OF PHYSIOLOGY-LONDON

CD68/macrosialin: not just a histochemical marker

(2016) Dimitry A Chistiakov et al.   LABORATORY INVESTIGATION

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

(2016) Abdellatif Benraiss et al.   Nature Communications

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques

(2016) Kanchan Bisht et al.   Jove-Journal of Visualized Experiments

Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week

(2015) Maria Nikodemova et al.   JOURNAL OF NEUROIMMUNOLOGY

Altered Sensory Experience Exacerbates Stable Dendritic Spine and Synapse Loss in a Mouse Model of Huntington's Disease

(2015) R. P. Murmu et al.   JOURNAL OF NEUROSCIENCE

Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers

(2015) Marios Politis et al.   NEUROBIOLOGY OF DISEASE

Mutant Huntingtin Downregulates Myelin Regulatory Factor-Mediated Myelin Gene Expression and Affects Mature Oligodendrocytes

(2015) Brenda Huang et al.   NEURON

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

(2014) Andrea Crotti et al.   NATURE NEUROSCIENCE

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease

(2013) R. P. Murmu et al.   JOURNAL OF NEUROSCIENCE

Striatal Pre-Enkephalin Overexpression Improves Huntington’s Disease Symptoms in the R6/2 Mouse Model of Huntington’s Disease

(2013) Stéphanie Bissonnette et al.   PLoS One

Role of cerebral cortex in the neuropathology of Huntington's disease

(2013) Ana M. Estrada-Sánchez et al.   Frontiers in Neural Circuits

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

(2012) Marie-Ève Tremblay et al.   GLIA

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Huntington’s Disease and the Striatal Medium Spiny Neuron: Cell-Autonomous and Non-Cell-Autonomous Mechanisms of Disease

(2012) Michelle E. Ehrlich   Neurotherapeutics

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

(2011) Andrew D. Kraft et al.   NEUROBIOLOGY OF AGING

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

(2011) Sonia Franciosi et al.   NEUROBIOLOGY OF DISEASE

Focussed Ion Beam Milling and Scanning Electron Microscopy of Brain Tissue

(2011) Graham Knott et al.   Jove-Journal of Visualized Experiments

A high-level 3D visualization API for Java and ImageJ

(2010) Benjamin Schmid et al.   BMC BIOINFORMATICS

Endoplasmic Reticulum Stress in Motor Neurons of the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis

(2010) Shoichi Sasaki   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

(2009) Jennifer Bradford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Counting synapses using FIB/SEM microscopy: a true revolution for ultrastructural volume reconstruction

(2009) Angel Merchan-Pérez   Frontiers in Neuroanatomy

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

(2008) Maria Björkqvist et al.   JOURNAL OF EXPERIMENTAL MEDICINE