Article
Oncology
Yiting Wang, Yufan Sun, Hai Li, Jie Xu
Summary: This study reveals the crucial role of Galectin-8 (Gal-8) in regulating tumor immunosuppression. It provides evidence that Gal-8 can modulate the tumor immune microenvironment, affecting the distribution and function of immune cells. Gal-8 expression is associated with lymph node metastasis and immunophenotyping in breast and colorectal cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jianbo An, Yushi Nagaki, Satoru Motoyama, Yuta Kuze, Midori Hoshizaki, Kohei Kemuriyama, Tomokazu Yamaguchi, Takashi Ebihara, Yoshihiro Minamiya, Yutaka Suzuki, Yumiko Imai, Keiji Kuba
Summary: Metastasis predicts poor prognosis in cancer patients. Galectin-7 is identified as a crucial mediator of metastasis associated with immunosuppression. Galectin-7 is expressed in the immunosuppressive tumor microenvironment and plays an important role in tumor metastasis to lymph nodes and lungs.
Article
Immunology
John T. Schroeder, Anja P. Bieneman
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic with significant health and socioeconomic consequences. Infection with SARS-CoV-2 can lead to lung injury and acute respiratory distress syndrome (ARDS), possibly due to a dysregulated innate immune response or cytokine release syndrome (CRS). The spike protein of SARS-CoV-2 plays a crucial role in the infection process, and recent research has shown that the S1 subunit can activate monocytes to produce cytokines associated with CRS in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jie Li, Xiao-gang Liu, Rui-liang Ge, Yu-peng Yin, Yong-da Liu, Wan-peng Lu, Mei Huang, Xue-ying He, Jinghan Wang, Guoxiang Cai, Shu-han Sun, Ji-hang Yuan
Summary: This study reveals that ERMAP on cancer cells can deliver an 'eat me' signal to Kupffer cells by binding to Gal-9-dectin-2 on Kupffer cells and triggering phagocytosis.
Article
Chemistry, Multidisciplinary
Yang Li, Yan Li, Jing Xia, Qing Yang, Yijie Chen, Hui Sun
Summary: The study demonstrates that the antitumor activity of AAL/AAGL is highly correlated with the 3'-sulfo-TF antigen, and increasing GAL3ST2 expression can enhance its antitumor effect, while ST3GAL1 expression decreases its inhibitory ratio.
Article
Cell Biology
Lingxin Zhu, Yi Tang, Xiao-Yan Li, Samuel A. Kerk, Costas A. Lyssiotis, Xiaoyue Sun, Zijun Wang, Jung-Sun Cho, Jun Ma, Stephen J. Weiss
Summary: The interaction between metalloproteins Mmp9 and Mmp14 and carbohydrate-binding protein galectin-3 plays a critical role in osteoclast-mediated bone resorption. The ability of Mmp9 and Mmp14 to degrade galectin-3 on the cell surface depends on its binding protein Lrp-1. These findings reveal a previously unrecognized galectin-3/Lrp1 axis that regulates both the transcriptional programs and intracellular signaling cascades essential for osteoclast function.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Fei Li, Xufei Du, Fen Lan, Na Li, Chao Zhang, Chen Zhu, Xiaohui Wang, Yicheng He, Zhehua Shao, Haixia Chen, Man Luo, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen
Summary: The study reveals that eosinophils promote tumor cell migration and metastasis formation through secreting CCL6, which can be inhibited by targeting CCR1. This suggests a potential approach to preventing metastatic disease.
Article
Multidisciplinary Sciences
Cynthia Buelck, Elisabeth E. L. Nystroem, Tomas Koudelka, Michael Mannbar-Frahm, Gerrit Andresen, Mariem Radhouani, Florian Tran, Franka Scharfenberg, Friederike Schrell, Fred Armbrust, Eileen Dahlke, Bei Zhao, Alex Vervaeke, Franziska Theilig, Philip Rosenstiel, Philipp Starkl, Stephan P. Rosshart, Helmut Fickenscher, Andreas Tholey, Gunnar C. Hansson, Christoph Becker-Pauly
Summary: The metalloproteases meprin alpha and meprin beta are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease. They form covalently linked heterodimers in the colon, and the major intestinal substrate for these heterodimers is galectin-3. The cleavage of galectin-3 by meprin alpha/beta heterodimers may play a key role in colon host-microbiome homeostasis.
Review
Biochemistry & Molecular Biology
Yehiel Zick
Summary: Galectin-8 is a protein that regulates cell adhesion, cell proliferation, apoptosis, and immune responses. It induces the expression and secretion of cytokines and chemokines, promoting cell migration and tumor development. Its involvement in the "cytokine storm" associated with poor prognosis in COVID-19 patients suggests its significance in the disease.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Kazuko Hachisu, Akiko Tsuchida, Yoshio Takada, Mamoru Mizuno, Hiroko Ideo
Summary: This study investigated the glycan profiles of cell surface proteins and glycosphingolipids (GSLs) in gastric cancer cells and found that the expression of galectin-4 affects the glycan structure of GSLs, providing further evidence for the importance of galectin-4 in glycosylation regulation in gastric cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Carla P. Concepcion, Sai Ma, Lindsay M. LaFave, Arjun Bhutkar, Manyuan Liu, Lydia P. DeAngelo, Jonathan Y. Kim, Isabella Del Priore, Adam J. Schoenfeld, Manon Miller, Vinay K. Kartha, Peter M. K. Westcott, Francisco J. Sanchez-Rivera, Kevin Meli, Manav Gupta, Roderick T. Bronson, Gregory J. Riely, Natasha Rekhtman, Charles M. Rudin, Carla F. Kim, Aviv Regev, Jason D. Buenrostro, Tyler Jacks
Summary: The loss of Smarca4 results in increased sensitivity to malignant transformation and tumor progression in lung cells, leading to advanced dedifferentiated tumors and higher metastatic incidence. Smarca4-deficient tumors lack lung lineage transcription factor activities and resemble a metastatic cell state, suggesting a critical role of Smarca4 in regulating cellular transformation and metastasis during lung cancer evolution.
Article
Multidisciplinary Sciences
Xing Chen, Chunyu Yu, Xinhua Liu, Beibei Liu, Xiaodi Wu, Jiajing Wu, Dong Yan, Lulu Han, Zifan Tang, Xinyi Yuan, Jianqiu Wang, Yue Wang, Shumeng Liu, Lin Shan, Yongfeng Shang
Summary: This study reveals that the carbohydrate binding protein galectin-3 acts as a sensor for lipopolysaccharide (LPS) and regulates the mTORC1 signaling pathway and glucose metabolism, playing a crucial role in diabetes and cancer.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Xiao-dong Zhu, Qi Zhang, Yang Wang, Ming-rui Jiang, Muhammad Ali, Qian-nan Sun, Dao-rong Wang
Summary: This study aimed to investigate the expression, prognostic value, and molecular mechanism of galectin-8 in gastric cancer (GC). The results showed that galectin-8 expression levels were significantly increased in GC tissues and cells and were positively correlated with clinical stage, histological subtype, and lymph node metastasis. Knockdown of galectin-8 inhibited GC cell proliferation by decreasing Raf, Mek, and K-Ras protein expression levels through the activation of the Ras signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Nir Yogev, Tanja Bedke, Yasushi Kobayashi, Leonie Brockmann, Dominika Lukas, Tommy Regen, Andrew L. Croxford, Alexei Nikolav, Nadine Hovelmeyer, Esther von Stebut, Marco Prinz, Carles Ubeda, Kevin J. Maloy, Nicola Gagliani, Richard A. Flavell, Ari Waisman, Samuel Huber
Summary: Interleukin (IL)-10 is a prototypical anti-inflammatory cytokine that plays a role in immune homeostasis. In CNS inflammation, T-cell-derived IL-10 can promote inflammation and enhance autoimmunity.
Article
Oncology
Elena Obrador, Rosario Salvador-Palmer, Rafael Lopez-Blanch, Maria Oriol-Caballo, Paz Moreno-Murciano, Jose M. Estrela
Summary: Malignant melanoma, a cancer derived from melanocytes, can develop on skin, mucous membranes, and other locations. N-acetylcysteine (NAC), an antioxidant drug, may play a role in preventing cancer, but high doses could potentially cause metastatic spread of melanoma. Antioxidant properties of NAC and other promoters of glutathione synthesis should be used cautiously in cancer patients to avoid promoting metastatic growth.
Review
Biochemistry & Molecular Biology
Michael Selitrennik, Sima Lev
BIOCHEMICAL SOCIETY TRANSACTIONS
(2016)
Article
Oncology
Nandini Verma, Anna-Katharina Mueller, Charu Kothari, Effrosini Panayotopoulou, Amir Kedan, Michael Selitrennik, Gordon B. Mills, Lan K. Nguyen, Sungyoung Shin, Thomas Karn, Uwe Holtrich, Sima Lev
Article
Oncology
Effrosini G. Panayotopoulou, Anna-Katharina Muller, Melanie Boerries, Hauke Busch, Guohong Hu, Sima Lev
Article
Biochemical Research Methods
Sung-Young Shin, Anna-Katharina Mueller, Nandini Verma, Sima Lev, Lan K. Nguyen
PLOS COMPUTATIONAL BIOLOGY
(2018)
Article
Cell Biology
Amir Kedan, Nandini Verma, Ashish Saroha, Michal Shreberk-Shaked, Anna-Katharina Mueller, Nishanth Ulhas Nair, Sima Lev
CELL DEATH & DISEASE
(2018)
Review
Cell Biology
Diego Peretti, SoHui Kim, Roberta Tufi, Sima Lev
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Sima Lev
BIOCHEMICAL SOCIETY TRANSACTIONS
(2020)
Article
Multidisciplinary Sciences
Nandini Verma, Yaron Vinik, Ashish Saroha, Nishanth Ulhas Nair, Eytan Ruppin, Gordon Mills, Thomas Karn, Vinay Dubey, Lohit Khera, Harsha Raj, Flavio Maina, Sima Lev
Article
Multidisciplinary Sciences
Yaron Vinik, Francisco Gabriel Ortega, Gordon B. Mills, Yilling Lu, Menucha Jurkowicz, Sharon Halperin, Mor Aharoni, Mordechai Gutman, Sima Lev
Article
Chemistry, Multidisciplinary
Fabienne Lamballe, Fahmida Ahmad, Yaron Vinik, Olivier Castellanet, Fabrice Daian, Anna-Katharina Muller, Ulrike A. Kohler, Anne-Laure Bailly, Emmanuelle Josselin, Remy Castellano, Christelle Cayrou, Emmanuelle Charafe-Jauffret, Gordon B. Mills, Vincent Geli, Jean-Paul Borg, Sima Lev, Flavio Maina
Summary: A unique mouse model of TNBC has been developed, faithfully recapitulating the intertumoral heterogeneity of human TNBC tumors. Targeting both WEE1 and BCL-XL synergistically kills TNBC cells and efficiently induces tumor regression, providing potential therapeutic targets for TNBC treatment.
Article
Biochemistry & Molecular Biology
Lohit Khera, Sima Lev
Summary: AXL, a tyrosine kinase receptor in the TAM family, is a promising therapeutic target for various hematological cancers and solid tumors. It plays a role in multiple protumorigenic processes and targeting AXL alone or in combination with other therapeutic agents could be beneficial, particularly in triple negative breast cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Anna-Katharina Mueller, Ulrike A. Koehler, Sebastien Trzebanski, Yaron Vinik, Harsha Mohan Raj, Jean-Antoine Girault, Nir Ben-Chetrit, Antonio Maraver, Steffen Jung, Sima Lev
Summary: This study finds that macrophage infiltration in mammary tumors is associated with tumor progression, metastasis, and poor clinical outcome. Ablation of the TYRO3 kinase PYK2 can reduce the number of infiltrating macrophages, inhibit tumor angiogenesis and growth, and modulate monocyte recruitment, macrophage polarization, and tumor angiogenesis. Targeting PYK2 may be an effective strategy to modulate the tumor microenvironment and sensitize breast cancer to immunotherapy.
Article
Cell Biology
Nishanth Belugali Nataraj, Ashish Noronha, Joo Sang Lee, Soma Ghosh, Harsha Raj Mohan Raju, Arunachalam Sekar, Binyamin Zuckerman, Moshit Lindzen, Emilio Tarcitano, Swati Srivastava, Michael Selitrennik, Ido Livneh, Diana Drago-Garcia, Oscar Rueda, Carlos Caldas, Sima Lev, Tamar Geiger, Aaron Ciechanover, Igor Ulitsky, Rony Seger, Eytan Ruppin, Yosef Yarden
Summary: By establishing multi-omics pipelines, we discovered that overexpression of NUP93 is associated with aggressive human mammary tumors, enhancing their migration and invasion capabilities. NUP93 is involved in nuclear transport, activating various signaling pathways and ultimately contributing to tumor growth and metastasis. Targeting this nuclear transport process with myristoylated peptides can inhibit tumor growth and metastasis.
Article
Medicine, Research & Experimental
Olivier Castellanet, Fahmida Ahmad, Yaron Vinik, Gordon B. Mills, Bianca Habermann, Jean-Paul Borg, Sima Lev, Fabienne Lamballe, Flavio Maina
Summary: The study found that high expression levels of BCL-XL and specific cell cycle regulators correlate with poor survival outcomes in TNBC patients. Co-targeting BCL-XL and CDK1/2/4 can inhibit tumor growth, synergistically inhibiting cell viability by combinatorial depletion of survival and RTK/AKT signals, and concomitantly restoring FOXO3a tumor suppression actions.